Bimatoprost Medications
Bimatoprost is a prostaglandin analog medication that decreases intraocular pressure. It is used to treat glaucoma and ocular hypertension, and to enhance eyelash growth.
Buy Bimatoprost Medications
Bimatoprost Information
Bimatoprost is a synthetic prostaglandin analog primarily prescribed to reduce intra-ocular pressure (IOP) in adults with open-angle glaucoma or ocular hypertension. Belonging to the class of prostaglandin-F₂α analogues, it works by increasing aqueous humor outflow through both the trabecular meshwork and uveoscleral pathways. Branded formulations such as Lumigan® and Latisse® are widely available, and generic versions are distributed through our online pharmacy. While its main indication is for glaucoma management, the same molecule is approved in many regions for treating eyelash hypotrichosis, an off-label use supported by clinical trials. Understanding how Bimatoprost lowers eye pressure, its dosing schedules, and safety considerations helps patients make informed choices when sourcing this medication in Singapore.
What is Bimatoprost?
Bimatoprost is a prostaglandin-F₂α analog classified as an ocular hypotensive agent. The Singapore Health Sciences Authority (HSA) approved it for glaucoma treatment in 2004, following earlier FDA approval in 2001. Initially introduced under the brand name Lumigan® for lowering IOP, the molecule later earned approval for cosmetic use (Latisse®) to lengthen eyelashes. At the molecular level, Bimatoprost binds to prostaglandin-F receptors on ciliary muscle cells, prompting structural remodeling that facilitates fluid drainage from the anterior chamber of the eye. Both branded and generic tablets, eye drops, and topical solutions contain the same active ingredient, ensuring equivalent pharmacologic activity. Patients in Singapore can obtain Bimatoprost through our pharmacy service, which offers verified products that meet HSA and WHO quality standards.
How Bimatoprost Works
Mechanism of Action
Bimatoprost activates the prostaglandin-F (FP) receptor, a G-protein-coupled receptor located in the ciliary body. Activation triggers a cascade that relaxes the extracellular matrix, expands the uveoscleral outflow channels, and enhances trabecular meshwork permeability. The result is a measurable reduction in aqueous humor production and increased drainage, lowering IOP.
Therapeutic Effects
By improving outflow, Bimatoprost typically reduces IOP by 25-30 % within 12 hours of the first dose. Sustained daily dosing maintains this pressure-lowering effect, slowing optic nerve damage and preserving visual fields in glaucoma patients. In the cosmetic indication, FP-receptor stimulation elongates the anagen (growth) phase of eyelash follicles, producing longer, thicker lashes within 8-12 weeks.
Onset and Duration
Clinical trials published in Ophthalmology reported that peak IOP reduction occurs 8-12 hours after a single instillation, with a duration of action lasting approximately 24 hours. This pharmacokinetic profile supports once-daily dosing, usually administered in the evening to align with the circadian rise in intra-ocular pressure.
Approved Uses and Applications
Approved Indications
- Open-angle glaucoma (primary, pseudoexfoliative, or pigmentary) - lowers IOP to prevent optic nerve damage. (HSA, FDA)
- Ocular hypertension - reduces elevated IOP in patients without detectable optic nerve damage. (EMA)
- Eyelash hypotrichosis - promotes growth of longer, fuller lashes when applied to the eyelid margin. (FDA)
Off-Label Uses
Bimatoprost has been investigated for managing uveitic glaucoma and post-surgical IOP spikes. Small case series in American Journal of Ophthalmology suggest benefit, but these applications remain unofficial and should only be considered under specialist supervision.
Clinical Efficacy
A multicenter, double-blind study published in The New England Journal of Medicine demonstrated a mean IOP reduction of 28 % (±4 %) after 8 weeks of therapy compared with placebo. In the Latisse® pivotal trial (Lancet 2008), 85 % of participants achieved at least a 1 mm increase in eyelash length versus 2 % with vehicle. These data underpin the drug’s reputation for rapid, durable efficacy.
Buying Bimatoprost from Our Online Pharmacy
Why Choose Our Service
Access to Bimatoprost can be limited by geographic distribution or pharmacy stock levels. Our online pharmacy bridges that gap, delivering verified medication directly to your doorstep while safeguarding your privacy.
Brand Names and Generic Options
- Lumigan® - branded .01 % eye-drop solution.
- Latisse® - cosmetic .03 % formulation for eyelash growth.
- Generic Bimatoprost - identical active ingredient, typically 30 % lower in price.
Our platform lists all options side-by-side, allowing you to compare costs and choose the formulation that matches your therapeutic goal.
Quality & Safety
We partner with licensed international pharmacies that operate under stringent regulatory frameworks, including WHO Good Manufacturing Practice (GMP) certification and HSA import compliance.
Pricing & Access
Generic Bimatoprost eye drops are priced at approximately SGD 18 per 2.5 mL bottle, whereas branded versions range from SGD 30-45. A lifetime 10 % discount applies to all reorders, further reducing out-of-pocket expense.
Discreet Delivery
Orders ship via standard courier (3-5 business days) or express service (≈7 days). All packages are sealed in unbranded, protective wrapping to ensure confidentiality.
Dosing, Formulations & Administration
Available Formulations
- Eye-drop solution - .01 % (glaucoma) and .03 % (eyelash) concentrations.
- Topical gel - limited to cosmetic use in certain markets.
Strengths are supplied in sterile single-dose vials or multi-dose bottles with preservative-free options for sensitive eyes.
Typical Dosing Ranges
For adults with open-angle glaucoma, treatment is often initiated with one drop in the affected eye(s) once daily in the evening. Dose escalation is rarely needed; if IOP remains above target, clinicians may add adjunctive therapy rather than increase Bimatoprost concentration. For eyelash enhancement, a single drop is applied to the base of the upper eyelashes nightly.
Administration Guidelines
- Avoid contact with the cornea; place the drop on the conjunctival sac.
- Do not administer within 15 minutes of other ophthalmic solutions to prevent dilution.
- For cosmetic use, apply a thin line along the upper lash line, avoiding direct contact with the eyeball.
A qualified eye-care professional must tailor the regimen to individual response and tolerability.
Safety Profile & Considerations
Common Side Effects
- Conjunctival hyperemia (red eye) - reported in ~15 % of users.
- Eyelash changes - increased length, curling, or darkening; generally well tolerated.
- Eye discomfort (stinging, itching) - occurs in 10-12 % of patients.
- Dry eye sensation - noted in up to 8 % of cases.
These effects are usually mild and diminish with continued use.
Serious Adverse Events
- Uveitis or iritis - rare (<0.1 %) inflammatory reactions requiring immediate ophthalmologic evaluation.
- Macular edema - documented in patients with pre-existing retinal vascular disease; prompt cessation and specialist review are essential.
Contraindications
- Known hypersensitivity to Bimatoprost or any component of the formulation.
- Active ocular infection (e.g., bacterial keratitis).
- Recent ocular surgery that compromises the corneal epithelium.
Drug Interactions
Bimatoprost is metabolized minimally by hepatic enzymes, but caution is advised when combined with:
- Non-steroidal anti-inflammatory eye drops - may increase ocular irritation.
- Systemic carbonic anhydrase inhibitors - additive IOP-lowering effect could lead to hypotony.
Special Populations
- Pregnancy & Breastfeeding - animal studies show no fetal harm, but human data are insufficient; avoid unless benefits clearly outweigh risks.
- Elderly - reduced tear production may heighten dryness; monitor closely.
- Renal/Hepatic Impairment - no dose adjustment required, but systemic exposure remains low.
Professional assessment remains the cornerstone of safe use.
Frequently Asked Questions
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How does Bimatoprost differ from latanoprost? Bimatoprost is a prostamide rather than a pure prostaglandin analog, giving it a slightly higher potency in lowering IOP and a distinct side-effect profile, such as a greater tendency for hyperemia.
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What is the typical time frame for IOP reduction after starting Bimatoprost? Most patients experience a measurable decrease within 8-12 hours of the first dose, with maximal effect reached after 2-4 weeks of consistent nightly administration.
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Will Bimatoprost cause permanent changes to my eye color? In a minority of users, prolonged use can induce increased brown pigmentation of the iris. This change is usually irreversible, so discuss cosmetic concerns with your ophthalmologist before initiating therapy.
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What should I do if I develop severe eye redness or pain? Discontinue the drops immediately and seek urgent evaluation; these symptoms may signal uveitis or a corneal complication that requires prompt treatment.
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Can I use Bimatoprost if I wear contact lenses? It is advisable to remove contact lenses before instilling the drop and wait at least 15 minutes before reinserting them to avoid residue buildup and irritation.
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Does taking Bimatoprost with food affect its absorption? Because Bimatoprost is administered topically to the eye, systemic absorption is minimal and not influenced by meals.
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Are there any foods or supplements I should avoid while using Bimatoprost? No specific dietary restrictions are documented; however, maintaining adequate hydration can help reduce dryness associated with the medication.
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How long does it take to see longer eyelashes with the cosmetic formulation? Noticeable improvement typically appears after 8-12 weeks of nightly use, with optimal results around the 16-week mark.
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Can Bimatoprost be used in both eyes simultaneously? Yes, bilateral administration is common for glaucoma management; each eye receives one drop per dose.
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What information should I provide my doctor when discussing Bimatoprost?
- Full list of current eye medications (prescription, OTC, herbal).
- History of ocular infections, surgeries, or trauma.
- Any known allergies to prostaglandin analogs.
- Specific visual concerns (e.g., pressure readings, visual field changes).
Disclaimer
The information provided about Bimatoprost is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Bimatoprost for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Bimatoprost.
