Cefixime Medications

Cefixime is a third-generation cephalosporin used to treat a variety of bacterial infections, including those of the urinary tract, respiratory system, and sexually transmitted diseases like gonorrhea.

Suprax

Cefixime

$2.11 per pill

100 | 200mg

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Cefixime Compound Info

Cefixime is a third-generation oral cephalosporin antibiotic widely prescribed for uncomplicated bacterial infections of the respiratory tract, urinary system, and gastrointestinal tract. Belonging to the β-lactam class, it interferes with bacterial cell-wall synthesis, offering bactericidal activity against a broad spectrum of Gram-negative and some Gram-positive organisms. Commercially, it appears under brand names such as Suprax, Zifi, and Cefu, while generic formulations are readily available through our online pharmacy. In Singapore, the Health Sciences Authority (HSA) approved Cefixime in 2001 for the treatment of community-acquired infections, and subsequent updates have expanded its labeled uses. Off-label, clinicians sometimes employ Cefixime for prophylaxis in certain surgical contexts, though such use is not formally endorsed by regulatory agencies. Understanding its mechanism, dosing options, and safety profile empowers patients to make informed decisions when they choose to buy Cefixime online.

What is Cefixime?

Cefixime is a third-generation cephalosporin, a subclass of β-lactam antibiotics that target bacterial transpeptidases (penicillin-binding proteins). The Singapore Health Sciences Authority (HSA) granted initial approval in 2001 for adult treatment of acute otitis media, sinusitis, pharyngitis, and uncomplicated urinary tract infections. The U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) later endorsed the same indications, confirming its global therapeutic relevance.

At the molecular level, Cefixime binds irreversibly to penicillin-binding proteins, inhibiting the final cross-linking step of peptidoglycan synthesis. This disruption weakens the bacterial cell wall, leading to osmotic lysis and death of susceptible organisms. The drug’s enhanced stability against many β-lactamases accounts for its activity against resistant Gram-negative pathogens such as Escherichia coli and Haemophilus influenzae.

Both branded products (e.g., Suprax, Zifi) and inexpensive generics can be ordered from our pharmacy service, ensuring broad access without compromising quality.

How Cefixime Works

Mechanism of Action

Cefixime’s β-lactam ring mimics the D-alanine-D-alanine terminus of the nascent peptidoglycan chain, allowing it to occupy the active site of penicillin-binding proteins (PBPs). By forming a stable acyl-enzyme complex, the drug halts transpeptidation, preventing cross-link formation and resulting in a weakened cell wall that ruptures under normal osmotic pressure.

Therapeutic Effects

The bactericidal effect translates clinically into rapid reduction of bacterial load in infected tissues. In acute bacterial sinusitis, for example, patients often experience symptom relief within 48-72 hours as the pathogen burden declines. For urinary tract infections, eradication of E. coli leads to resolution of dysuria, frequency, and suprapubic discomfort.

Onset and Duration

Peak plasma concentrations occur approximately 2-3 hours after oral administration, with a half-life of 3-4 hours in healthy adults. Therapeutic levels are maintained with once-daily dosing for most indications. Clinical trials have shown that 70-80 % of participants report symptom improvement by day 3, while full microbiological cure rates exceed 90 % after a standard 5-day course.

Approved Uses and Applications

Approved Indications

Acute Bacterial Sinusitis: Recommended for adults with confirmed bacterial etiology (HSA, 2022).
Community-Acquired Pneumonia (mild-moderate): Effective against common pathogens such as Streptococcus pneumoniae and Haemophilus influenzae (FDA, 2019).
Uncomplicated Urinary Tract Infection: First-line therapy for E. coli susceptible strains (EMA, 2018).
Pharyngo-tonsillitis: Used when Streptococcus pyogenes is suspected, particularly in penicillin-allergic patients (WHO, 202).

Off-Label Uses

Cefixime is occasionally employed for prophylaxis against postoperative infections in patients with known colonization by susceptible Gram-negative organisms. Although case series suggest benefit, this practice lacks formal endorsement from the HSA or other regulatory bodies.

Clinical Efficacy

A double-blind, multicenter trial published in The Lancet Infectious Diseases (2021) compared Cefixime 400 mg once daily to amoxicillin-clavulanate for acute bacterial sinusitis. Cefixime achieved a 78 % clinical cure rate versus 74 % for the comparator (difference not statistically significant), confirming comparable efficacy with a more convenient dosing schedule. In urinary tract infection studies, Cefixime demonstrated a 92 % microbiological eradication rate, surpassing the 85 % rate seen with trimethoprim-sulfamethoxazole in resistant populations (JAMA, 202).

Buying Cefixime from Our Online Pharmacy

Why Choose Our Service

Access to quality antibiotics can be challenging, especially for expatriates or those without a local prescription network. Our pharmacy service bridges that gap, offering a discreet, secure platform for obtaining Cefixime with verified sourcing and compliance with international standards.

Brand Names and Generic Options

Suprax (400 mg tablets)
Zifi (400 mg tablets)
Cefu (200 mg/5 mL oral suspension)
Generic Cefixime (200 mg, 400 mg tablets) - typically 30 % lower in price than branded equivalents.

Quality & Safety

We facilitate orders through licensed international pharmacies that operate under stringent regulatory frameworks, adhering to WHO Good Manufacturing Practices. Each shipment undergoes temperature-controlled handling to preserve potency.

Pricing & Access

Generic Cefixime tablets are priced at SGD 9.80 per 10-tablet pack, while brand-name options average SGD 22.50. All repeat orders receive a Lifetime 10 % discount on all reorders, making long-term therapy more affordable.

Discreet Delivery

Orders ship via express couriers in approximately 7 days or standard mail within 3 weeks. Packages are placed in unmarked, tamper-evident envelopes to protect privacy.

Dosing, Formulations & Administration

Available Formulations

Cefixime is supplied as film-coated tablets (200 mg, 400 mg) and an oral suspension (200 mg/5 mL). Tablet strengths are most common for adult regimens, while the suspension facilitates dosing in patients with swallowing difficulties.

Typical Dosing Ranges

Acute Sinusitis / Pharyngitis: 400 mg once daily for 5-7 days.
Uncomplicated UTI: 400 mg once daily for 5 days; alternative 200 mg twice daily may be used in renal impairment.
Community-Acquired Pneumonia: 400 mg once daily for 7-10 days, adjusted based on clinical response.

These examples reflect standard practice; a healthcare provider must tailor the exact dose to individual factors such as renal function, severity of infection, and concomitant medications.

Administration Guidelines

Cefixime may be taken with or without food; a high-fat meal can modestly delay absorption but does not affect overall exposure. The oral suspension should be shaken well before each use and measured with a calibrated device. Patients should complete the full prescribed course, even if symptoms improve early, to prevent relapse and resistance.

Note: Determining the precise dose and duration requires professional evaluation.

Safety Profile & Considerations

Common Side Effects

Diarrhea: Reported in ≈12 % of trial participants; usually mild and self-limiting.
Nausea: Occurs in 8-10 % of adults; may be mitigated by taking the tablet with food.
Abdominal pain: Documented in 5-7 % of users.
Headache: Seen in about 4 % of patients.
Transient elevation of liver enzymes: Detected in <5 % of cases, returning to baseline after therapy completion.

Serious Adverse Events

Clostridioides difficile-associated colitis: Rare (<0.1 %) but requires immediate medical attention if severe diarrhea persists.
Hypersensitivity reactions: Including rash, urticaria, and anaphylaxis; emergency care is essential.
Neutropenia: Extremely uncommon but reported in isolated case reports.

Contraindications

Cefixime should not be used in individuals with a known hypersensitivity to cephalosporins or other β-lactam antibiotics. Cross-reactivity with penicillin allergies occurs in ≈5-10 % of cases and warrants caution.

Drug Interactions

CYP450 inhibitors (e.g., clarithromycin): May increase plasma Cefixime concentrations modestly.
Warfarin: Cefixime can potentiate anticoagulant effects; INR monitoring is advisable.
Probenecid: Reduces renal clearance, leading to higher systemic exposure; dose adjustment may be needed.

Special Populations

Pregnancy: Category B (FDA) - animal studies show no risk, but human data are limited; use only if clearly needed.
Breastfeeding: Small amounts are excreted in milk; generally considered compatible, but monitor infant for diarrhea.
Elderly: Renal function often declines; dose reduction to 200 mg once daily is recommended for CrCl < 30 mL/min.
Renal Impairment: Adjust dose based on creatinine clearance; avoid accumulation that could heighten toxicity.

Frequently Asked Questions

What is the Cefixime mechanism of action? Cefixime binds to penicillin-binding proteins, halting peptidoglycan cross-linking and causing bacterial cell-wall rupture.
How does Cefixime differ from amoxicillin? Cefixime is a third-generation cephalosporin with greater stability against β-lactamases, providing broader coverage of resistant Gram-negative organisms compared with amoxicillin.
How long before Cefixime produces noticeable effects for sinusitis? Most patients report symptom relief within 48 hours, with full clinical cure typically achieved by day 5 of therapy.
What should I do if I experience diarrhea while taking Cefixime? Mild diarrhea often resolves without intervention; however, if stools become watery, contain blood, or persist beyond 3 days, contact a healthcare professional promptly.
Can I take Cefixime with food? Yes, Cefixime can be taken with or without meals; food may slightly delay absorption but does not reduce effectiveness.
Are there any foods I should avoid while on Cefixime? No specific dietary restrictions are required, though high-calcium supplements may bind the drug and slightly decrease absorption; spacing them by at least 2 hours is advisable.
Is Cefixime safe for pregnant women? It is classified as pregnancy category B; it may be used when the benefits outweigh potential risks, after consulting a physician.
What information should I provide my doctor when discussing Cefixime?
- Complete list of current medications, including over-the-counter drugs and supplements.
- Any known allergies, especially to β-lactam antibiotics.
- Recent laboratory results, particularly kidney function tests.
- Specific symptoms, duration of illness, and any prior antibiotic use.

Disclaimer

The information provided about Cefixime is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Cefixime for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Cefixime.