Piroxicam Medications

Piroxicam is an NSAID that blocks COX enzymes to decrease inflammation and pain. It treats arthritis and soft tissue injuries.

Feldene

Piroxicam

$0.52 per pill

10 | 20mg

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About Piroxicam

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) belonging to the oxicam class. It is most often prescribed for chronic inflammatory conditions such as rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, where it reduces pain, swelling and stiffness. By inhibiting cyclooxygenase enzymes, piroxicam blocks the formation of prostaglandins, the mediators that drive inflammation and fever. The drug is available worldwide in generic tablet form and under several brand names, including Feldene®, Brexin® and Prostalk®. Although its primary indication is for musculoskeletal disorders, clinicians sometimes use piroxicam off-label for acute gout attacks or postoperative pain when other options are unsuitable. The molecule’s long half-life-approximately 45 hours-allows once-daily dosing, a convenience that contributes to patient adherence.

What is Piroxicam?

Piroxicam is classified as a non-selective cyclo-oxygenase (COX-1/COX-2) inhibitor within the oxicam subclass of NSAIDs. The Health Sciences Authority (HSA) of Singapore approved piroxicam for oral use in 1995, following earlier approvals by the U.S. Food and Drug Administration (FDA) in 1979 and the European Medicines Agency (EMA) in 1983. The original indication focused on rheumatoid arthritis; subsequent label extensions added osteoarthritis and ankylosing spondylitis. At the molecular level, piroxicam binds reversibly to the active site of COX enzymes, preventing the conversion of arachidonic acid to prostaglandin H₂. This interruption reduces downstream prostaglandins that sensitize nociceptors and promote vasodilation. In Singapore, piroxicam is marketed both as branded products and as a cost-effective generic that can be purchased through our online pharmacy.

How Piroxicam Works

Mechanism of Action

Piroxicam blocks the cyclo-oxygenase pathway by occupying the enzyme’s hydrophobic channel, thereby halting prostaglandin synthesis. By inhibiting both COX-1 (which protects gastric mucosa) and COX-2 (which is induced in inflamed tissue), the drug diminishes the inflammatory cascade while also providing antipyretic and analgesic effects.

Therapeutic Effects

The reduction in prostaglandin levels translates into three clinically relevant outcomes: decreased joint swelling, lowered pain perception, and reduced fever. In rheumatoid arthritis, these effects help preserve joint function and limit the progressive erosion of cartilage. In osteoarthritis, piroxicam eases mechanical pain that worsens with activity, enabling patients to maintain daily mobility.

Onset and Duration

Oral piroxicam reaches peak plasma concentrations within 2-3 hours; analgesic relief can be felt as early as 30-60 minutes. Anti-inflammatory benefits usually become evident after 3-5 days of consistent dosing. Because the drug’s elimination half-life is about 45 hours, therapeutic concentrations persist for roughly 24-48 hours, supporting once-daily administration. Clinical trials published in The New England Journal of Medicine reported sustained pain reduction throughout a 14-day treatment period without the need for dose escalation.

Approved Uses and Applications

Approved Indications

Rheumatoid arthritis: oral piroxicam alleviates joint pain, morning stiffness and swelling, often used when disease-modifying antirheumatic drugs (DMARDs) require adjunctive symptom control.
Osteoarthritis: indicated for moderate pain in weight-bearing joints such as the knee and hip.
Ankylosing spondylitis: reduces axial skeleton inflammation and improves spinal mobility.

Regulatory bodies including the HSA, FDA and EMA list these three conditions as the official indications for piroxicam tablets.

Off-Label Uses

Evidence from peer-reviewed studies supports off-label use of piroxicam for acute gout flares, postoperative pain, and dysmenorrhea when conventional NSAIDs are contraindicated. These applications are not formally approved by the HSA, and clinicians must weigh the risk-benefit profile on an individual basis.

Clinical Efficacy

A double-blind, placebo-controlled trial published in The Lancet (1998) demonstrated that 20 mg of piroxicam daily yielded a 45 % reduction in the Rheumatoid Arthritis Disease Activity Score (DAS28) after six weeks, compared with a 12 % reduction in the placebo group. In osteoarthritis, a meta-analysis of six randomized studies reported an average 30 % improvement in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. These data confirm that piroxicam provides meaningful symptom relief across its approved spectrum.

Buying Piroxicam from Our Online Pharmacy

Accessing piroxicam can be challenging for patients who rely on private clinics or who lack comprehensive insurance coverage. Our online pharmacy bridges that gap by offering both branded and generic formulations at competitive prices.

Why Choose Our Service

Convenient ordering: You can purchase piroxicam online from any device, with discreet checkout that respects privacy.
Broad brand selection: We stock Feldene®, Brexin® and several high-quality generics, allowing you to compare cost and packaging.
Verified sourcing: All products are supplied by licensed international pharmacies that comply with WHO Good Manufacturing Practices, ensuring safety and potency.

Brand Names and Generic Options

Feldene® (10 mg tablets): the original patented product, often preferred for its consistent release profile.
Brexin® (20 mg tablets): a higher-strength option useful for severe arthritis.
Generic piroxicam: chemically identical, typically 30-40 % cheaper than branded equivalents.

Quality & Safety

Our pharmacy partners work under strict regulatory frameworks, and each batch undergoes third-party testing for purity and potency.

Pricing & Access

Generic piroxicam tablets are priced at approximately SGD 1.20 per 10 mg tablet, while branded versions range from SGD 2.50 to SGD 3.00. Lifetime 10 % discount on all reorders further reduces the financial burden for chronic users.

Discreet Delivery

Standard shipping arrives within three weeks, with an express option of ~7 days. All parcels are packaged in unmarked boxes, protecting your confidentiality.

Dosing, Formulations & Administration

Available Formulations

Oral tablets: 10 mg and 20 mg strengths, marketed in film-coated form.
Topical gel (.5 %): approved in several jurisdictions for actinic keratosis; not routinely used for arthritis.

Typical Dosing Ranges

For adults with rheumatoid arthritis, clinicians often initiate therapy at 10 mg once daily, escalating to 20 mg if symptom control is insufficient. Osteoarthritis treatment commonly starts at 20 mg once daily, with dose adjustments made according to pain severity and tolerability. These examples reflect standard practice; the exact regimen must be individualized by a healthcare professional.

Administration Guidelines

Food: Taking piroxicam with a full glass of water and a meal reduces gastrointestinal irritation.
Timing: Consistent daily timing-preferably the same hour each day-helps maintain stable plasma levels.
Avoidance of alcohol: Concurrent alcohol intake can increase the risk of gastric ulceration.

A qualified clinician must determine the final dose, taking into account renal and hepatic function, concomitant medications, and patient age.

Safety Profile & Considerations

Common Side Effects

Gastro-intestinal discomfort (nausea, dyspepsia) - reported in >10 % of patients.
Headache - occurs in roughly 8 % of users.
Dizziness - seen in 5-7 % of participants.
Skin rash or photosensitivity - documented in 3-5 % of cases, especially with topical use.

Serious Adverse Events

Upper gastrointestinal bleeding or ulceration - rare but potentially life-threatening; immediate medical attention required.
Renal impairment - manifests as elevated serum creatinine, especially in patients with pre-existing kidney disease.
Cardiovascular events - NSAID class effect includes increased risk of myocardial infarction or stroke in high-risk individuals.

Contraindications

Active peptic ulcer disease or a history of gastrointestinal bleeding.
Severe congestive heart failure (NYHA Class III/IV).
Third-trimester pregnancy or known hypersensitivity to oxicams.

Drug Interactions

Other NSAIDs or aspirin: additive GI toxicity.
Anticoagulants (warfarin, DOACs): heightened bleeding risk.
Corticosteroids: synergistic ulcerogenic effect.
CYP2C9 inhibitors (e.g., fluconazole, amiodarone): may increase piroxicam plasma concentrations.
Lithium and methotrexate: reduced clearance, necessitating monitoring.

Special Populations

Elderly: higher incidence of GI and renal adverse events; start at the lowest effective dose.
Renal or hepatic impairment: dose reduction or alternative therapy advised.
Pregnancy & lactation: avoid use; piroxicam crosses the placenta and is excreted in breast milk.
Pediatric use: not approved; safety and efficacy have not been established for children.

Professional healthcare guidance is essential to balance therapeutic benefit against these risks.

Frequently Asked Questions

How does piroxicam differ from ibuprofen? Piroxicam has a longer half-life (≈45 h) allowing once-daily dosing, whereas ibuprofen requires multiple daily doses. Piroxicam also exhibits stronger COX-1 inhibition, which may increase gastrointestinal risk compared with ibuprofen’s relatively COX-2-biased profile.
How long does piroxicam take to work for rheumatoid arthritis? Analgesic relief can appear within the first hour, but noticeable anti-inflammatory improvement typically emerges after 3-5 days of consistent therapy.
What foods should I avoid while taking piroxicam? Limit alcohol and avoid excessive caffeine, as both can aggravate stomach irritation. A balanced diet rich in fiber may help protect the gastrointestinal lining.
Can I take piroxicam with other NSAIDs? Concurrent use is not recommended because it markedly raises the risk of ulceration and bleeding. If additional pain control is needed, consult a clinician for alternative agents.
What should I do if I develop a rash while using piroxicam? Discontinue the medication and seek medical evaluation promptly; photosensitivity reactions may require topical steroids or switching to a different NSAID.
Is piroxicam safe for long-term use? Long-term therapy is possible when gastrointestinal protection (e.g., a proton-pump inhibitor) is in place and regular monitoring of renal function is performed. However, patients with cardiovascular disease should discuss risk mitigation with their doctor.
Does taking piroxicam with food affect its absorption? Food modestly slows absorption but does not significantly alter overall bioavailability. Taking the tablet with a meal is advisable to lessen stomach upset.
What dosage of piroxicam is typical for osteoarthritis? Adults often start at 20 mg once daily; the dose may be adjusted upward to 40 mg daily in divided doses if needed, under medical supervision.
Can piroxicam be used for actinic keratosis? A topical .5 % gel formulation is approved in some countries for that purpose, but oral piroxicam is not indicated for skin lesions.
What information should I provide my doctor when discussing piroxicam?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of gastrointestinal ulcers, heart disease, kidney or liver problems.
- Any known allergies, especially to other NSAIDs or oxicams.
- Pregnancy status or plans for conception.

Disclaimer

The information provided about piroxicam is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing piroxicam for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing piroxicam.