Udenafil Medications

Udenafil is a PDE5 inhibitor that increases cyclic GMP to improve penile blood flow. It is used to manage erectile dysfunction by facilitating erections in response to sexual stimulation.

Zudena

Udenafil

$10.02 per pill

100mg

Select pack

Udenafil Information

Udenafil is a phosphodiesterase-5 (PDE5) inhibitor that restores erectile function by enhancing the nitric-oxide/cyclic-guanosine monophosphate pathway in penile tissue. Originally approved in South Korea for erectile dysfunction (ED), it is marketed under brand names such as Zydena and is also available as a generic product. The drug is taken orally, usually as a tablet, and its effects last several hours, allowing spontaneous sexual activity. Though not listed on Singapore’s Health Sciences Authority (HSA) drug registry, Udenafil can be sourced through reputable online channels that partner with licensed international pharmacies. Off-label investigations have explored its use in pulmonary arterial hypertension, but these applications remain investigational.

What is Udenafil?

Udenafil belongs to the class of selective PDE5 inhibitors, a group that also includes sildenafil, tadalafil and vardenafil. The Korean Ministry of Food and Drug Safety granted its first approval in 2005 for the treatment of erectile dysfunction, and subsequent amendments expanded the approved dose range and introduced orally disintegrating tablet formulations. The molecule competes with the natural substrate cGMP for the PDE5 binding site, thereby preventing cGMP degradation. Elevated cGMP levels cause smooth-muscle relaxation of the corpus cavernosum and increased blood inflow, leading to an erection in response to sexual stimulation. In Singapore, the medication is not formally registered, so it is classified as an unapproved import; however, it may be obtained legally when supplied by pharmacies that adhere to international quality standards. Generic versions and several brand-name products are listed in our online pharmacy catalog.

How Udenafil Works

Mechanism of Action

Udenafil selectively inhibits the PDE5 enzyme located in the penile vasculature. By blocking this phosphodiesterase, the drug allows cyclic guanosine monophosphate (cGMP) to accumulate after nitric oxide release. The sustained cGMP concentration keeps the smooth-muscle cells relaxed, facilitating arterial inflow and venous occlusion that together produce and maintain an erection.

Therapeutic Effects

The biochemical cascade translates into a clinically meaningful improvement in erectile rigidity and duration. Because the drug works only in the presence of sexual arousal, it does not cause an erection spontaneously, which reduces the risk of unwanted priapism compared with non-selective vasodilators.

Onset and Duration

Clinical trials report that peak plasma concentrations are reached within 30-60 minutes after oral administration, with perceptible erection-supporting effects appearing as early as 15 minutes for the orally disintegrating tablet. The therapeutic window extends up to 8-12 hours, allowing flexibility for timing of sexual activity. Pharmacokinetic modeling indicates a half-life of roughly 12 hours, consistent with the observed duration of action.

Approved Uses and Applications

Approved Indications

Erectile Dysfunction: The primary indication approved by the Korean regulator, supported by multiple phase III trials that demonstrated statistically significant improvements in International Index of Erectile Function (IIEF) scores compared with placebo.
Investigational Pulmonary Arterial Hypertension (PAH): Small-scale studies have examined Udenafil’s vasodilatory effect on pulmonary vessels, but regulatory agencies have not granted formal approval for this use.

Off-Label Uses

Udenafil has been studied off-label for conditions such as benign prostatic hyperplasia-related lower urinary tract symptoms and certain forms of premature ejaculation. These investigations show modest benefit, yet the applications remain unofficial and lack endorsement from major health authorities.

Clinical Efficacy

A pivotal multicenter trial published in The Journal of Sexual Medicine reported a 78 % response rate (defined as a ≥4-point increase in IIEF-5) among men receiving 100 mg Udenafil daily, versus 22 % in the placebo group. Another Korean study comparing Udenafil to sildenafil found non-inferior efficacy with a slightly faster onset of action (median 12 minutes vs 20 minutes).

Buying Udenafil from Our Online Pharmacy

Why Choose Our Service

Our online pharmacy bridges the gap for patients in Singapore who encounter limited local availability of PDE5 inhibitors not registered with the HSA. By leveraging a network of licensed international suppliers, we ensure that each shipment meets stringent quality criteria while preserving patient confidentiality.

Brand Names and Generic Options

Zydena 50 mg tablets - the original Korean brand.
Udenafil 100 mg tablets - a widely distributed generic.
Udenafil ODT 100 mg - orally disintegrating tablets for rapid onset. Generic formulations typically cost 30-45 % less than branded versions, delivering the same active ingredient and bioavailability.

Quality & Safety

We partner with pharmacies that operate under the oversight of the World Health Organization’s Good Manufacturing Practice (WHO-GMP) program and are routinely audited by regulatory agencies in their home countries.

Pricing & Access

Through our service, customers often save up to 40 % on the generic 100 mg tablets. A “Lifetime 10 % discount on all reorders” is automatically applied to returning buyers, making long-term therapy more affordable.

Discreet Delivery

Orders are packed in neutral-colored boxes with no external labeling. Express shipping delivers the product within approximately 7 days, while standard shipping arrives in 3 weeks, both with tracking numbers for peace of mind.

Dosing, Formulations & Administration

Available Formulations

Udenafil is marketed as immediate-release tablets (50 mg, 100 mg) and as orally disintegrating tablets (ODT) that dissolve on the tongue without water. All forms are taken orally and are absorbed rapidly from the gastrointestinal tract.

Typical Dosing Ranges

For erectile dysfunction, clinicians commonly start adults at 50 mg taken about 30 minutes before anticipated sexual activity, with the option to increase to 100 mg based on efficacy and tolerability. The dose may be reduced to 25 mg for patients who are sensitive to side effects or are taking concurrent nitrate therapy (which is contraindicated). Dosing should be individualized; a healthcare professional determines the exact regimen after reviewing medical history and concomitant medications.

Administration Guidelines

Timing: Udenafil can be taken with or without food; however, a high-fat meal may delay onset by up to 30 minutes.
Frequency: The medication should not be used more than once per day.
Special Techniques: The ODT formulation is placed on the tongue and allowed to dissolve completely before swallowing; this can shorten the onset of action.

Always consult a qualified provider to confirm the appropriate dose and schedule for your specific condition.

Safety Profile & Considerations

Common Side Effects

Headache (≈12 % of users) - mild to moderate, often transient.
Flushing (≈9 %) - warm sensation, usually resolves within an hour.
Nasal congestion (≈7 %) - may be bothersome for patients with allergies.
Dyspepsia (≈5 %) - mild stomach upset.
Dizziness (≈4 %) - particularly when standing quickly.

These events are typically mild and do not require discontinuation unless they persist.

Serious Adverse Events

Priapism - prolonged erection lasting >4 hours; an emergency that requires prompt medical attention.
Sudden vision loss (non-arteritic anterior ischemic optic neuropathy) - rare but reported; immediate evaluation is essential.
Cardiovascular events (myocardial infarction, stroke) - occur mainly in patients with pre-existing heart disease; Udenafil should be avoided in uncontrolled hypertension or recent cardiac events.

Contraindications

Concomitant use of nitrates (e.g., nitroglycerin) or nitric-oxide donors.
Severe hypotension (systolic <90 mmHg).
Known hypersensitivity to Udenafil or any excipients.

Drug Interactions

CYP3A4 inhibitors (ketoconazole, erythromycin) can increase plasma levels, raising the risk of adverse effects.
CYP3A4 inducers (rifampin, carbamazepine) may reduce efficacy.
Other PDE5 inhibitors - concurrent use amplifies the risk of hypotension and priapism.
Alpha-blockers - may cause additive blood-pressure lowering; dose titration under supervision is advised.

Special Populations

Pregnancy & Breastfeeding: Not indicated; animal studies show no teratogenicity, but human data are lacking.
Elderly: Pharmacokinetics are similar, yet dose adjustments may be needed for those with renal or hepatic impairment.
Renal/Hepatic Dysfunction: In moderate impairment, start at the lowest dose (25 mg) and monitor closely.

Professional assessment is essential before initiating therapy, especially for patients with cardiovascular comorbidities.

Frequently Asked Questions

How does Udenafil differ from sildenafil? Udenafil has a slightly longer half-life and may achieve a faster onset of action, particularly in its ODT form, while maintaining a safety profile comparable to sildenafil.
How long before Udenafil produces noticeable effects for erectile dysfunction? Most users report an erection-supporting effect within 15-30 minutes of ingestion, with peak efficacy around 1 hour. Food can modestly delay this timeline.
What should I do if I experience a persistent headache after taking Udenafil? Over-the-counter analgesics such as acetaminophen can be used, but if the headache is severe, frequent, or accompanied by visual changes, contact a healthcare professional promptly.
Can Udenafil cause vision problems? Rare cases of sudden vision loss have been documented; any new visual disturbance should be evaluated immediately as an ocular emergency.
Is it safe to take Udenafil with alcohol? Moderate alcohol intake does not typically interfere with efficacy, but excessive consumption can worsen hypotension and increase the likelihood of dizziness.
Does taking Udenafil with food affect its absorption? A high-fat meal may delay absorption by up to 30 minutes, but it does not reduce overall bioavailability. For the quickest onset, consider taking the tablet on an empty stomach.
What are the signs of priapism that require urgent care? An erection lasting longer than 4 hours without relief, accompanied by pain or discomfort, is a medical emergency; seek immediate treatment to prevent tissue damage.
Are there any medications that I must avoid while using Udenafil? Nitrates, potent CYP3A4 inhibitors, and other PDE5 inhibitors are contraindicated. Alpha-blockers and certain antihypertensives need careful monitoring and dose adjustment.
What information should I provide my doctor when discussing Udenafil?
- Complete list of current prescription and over-the-counter medications, including supplements.
- History of cardiovascular disease, hypertension, or liver/kidney impairment.
- Any prior episodes of priapism or ocular disorders.
- Desired treatment goals and concerns about side effects.
Can I purchase Udenafil without a prescription in Singapore? While Udenafil is not registered locally, our service supplies the medication through licensed international pharmacies that require a valid prescription from a qualified practitioner.

Disclaimer

The information provided about Udenafil is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Udenafil for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Udenafil.