Buy Arcoxia

Arcoxia

Arcoxia (generic name etoricoxib) is a prescription medication classified as a selective cyclo-oxygenase-2 (COX-2) inhibitor. It is approved in Singapore for the management of moderate-to-severe pain associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis, as well as for postoperative pain control. The drug is supplied as oral tablets in strengths of 60 mg, 90 mg and 120 mg. By targeting inflammation at its enzymatic source, Arcoxia provides relief without the gastrointestinal irritation commonly seen with non-selective non-steroidal anti-inflammatory drugs (NSAIDs).

What is Arcoxia?

Arcoxia belongs to the NSAID family, yet distinguishes itself through a high degree of COX-2 selectivity. Developed by Merck Sharp & Dohme and marketed worldwide under the Arcoxia brand, the molecule etoricoxib was first approved by the European Medicines Agency in 2002. In Singapore, the Health Sciences Authority (HSA) has endorsed the product for the indications mentioned above, and it remains prescription-only. Generic versions containing the same active ingredient are available at lower cost, offering bioequivalent exposure while retaining the same safety profile.

How Arcoxia Works

COX-2 is an enzyme induced during inflammation; it converts arachidonic acid into prostaglandins that sensitize nociceptors and promote edema. By competitively binding to the catalytic site of COX-2, etoricoxib blocks this conversion, thereby reducing prostaglandin synthesis in inflamed tissues. Because COX-1, which protects the gastric mucosa and supports platelet function, is largely spared, the risk of ulceration and bleeding is comparatively lower.

Pharmacokinetically, Arcoxia is absorbed rapidly after oral ingestion, reaching peak plasma concentrations within 1 hour. Food can modestly delay absorption but does not affect overall exposure, allowing flexibility around meals. The drug exhibits a high degree of plasma protein binding (≈99 %) and is metabolised primarily by CYP3A4, with a terminal elimination half-life of roughly 22 hours. This duration underlies the once-daily dosing schedule for most chronic conditions and supports sustained analgesia after a single dose for acute pain.

Why Arcoxia is Used for Pain Relief and Inflammation Conditions

• Osteoarthritis: Joint degeneration triggers COX-2-driven prostaglandin production, which amplifies pain and stiffness. Clinical trials have demonstrated that etoricoxib reduces pain scores by an average of 30 % more than placebo, while improving functional mobility. The COX-2 selectivity translates into fewer gastrointestinal adverse events compared with conventional NSAIDs, making it a viable option for older patients who often carry ulcer risk.

• Rheumatoid arthritis: Inflammatory cytokines up-regulate COX-2 expression within synovial tissue. By curbing prostaglandin-mediated inflammation, Arcoxia alleviates joint swelling and tenderness. Studies integrating etoricoxib into disease-modifying regimens have shown comparable pain control to diclofenac, with a more favourable gastrointestinal safety profile.

• Ankylosing spondylitis: The axial skeleton inflammation characteristic of this disease is driven by COX-2 activity. Etoricoxib’s rapid onset (within a few hours) provides prompt relief of back pain and morning stiffness, enabling patients to maintain daily activities.

• Acute gouty arthritis: Gout attacks are marked by a sudden surge of urate crystal-induced inflammation, where COX-2 plays a pivotal role. A single 120 mg dose of Arcoxia can substantially reduce pain within 24 hours, offering an alternative to colchicine or corticosteroids when those agents are contraindicated.

• Post-operative pain: After surgical procedures, prostaglandin release contributes to nociceptive signaling. The long half-life of etoricoxib sustains analgesia for up to 24 hours, often allowing reduction of opioid consumption and associated side effects.

Off-Label and Investigational Uses of Arcoxia

In some clinical settings, physicians prescribe etoricoxib for conditions such as dysmenorrhea, migraine prophylaxis, and chronic low-back pain, citing its anti-inflammatory potency. Small-scale studies suggest that COX-2 inhibition may attenuate menstrual pain comparable to ibuprofen, while observational data indicate potential benefit in reducing migraine attack frequency. These applications remain off-label in Singapore; any such use should be guided by a qualified healthcare provider who can weigh the limited evidence against individual risk factors.

Off-label use only under qualified healthcare provider supervision.

Is Arcoxia Right for You?

Patients with inflammatory joint disease who require consistent pain control and who have a history of gastrointestinal ulceration often benefit from a COX-2-selective agent. Conversely, individuals with established cardiovascular disease, uncontrolled hypertension, or severe hepatic impairment should discuss alternatives, as COX-2 inhibition carries a modest thrombotic risk. Renal function declines with age, so dose adjustments may be necessary for elderly patients or those with chronic kidney disease. Pregnancy and lactation are contraindicated because safety data are insufficient.

If you have experienced intolerance to traditional NSAIDs, such as stomach upset or bleeding, Arcoxia may represent a safer option, provided your physician confirms no contraindicating cardiac or renal conditions exist.

Taking Arcoxia Effectively

Arcoxia tablets are intended for oral administration with a full glass of water. Because food does not markedly alter the drug’s bioavailability, you may take the medication with or without meals based on personal comfort. For chronic arthritis, a once-daily dose-typically the lowest effective strength-optimises adherence and maintains steady plasma levels. When prescribed for acute pain, the initial dose may be higher (e.g., 120 mg) followed by a reduced maintenance dose the next day.

If a dose is missed, take it as soon as you remember provided it is more than 12 hours before the next scheduled dose; otherwise, skip the missed tablet and resume the regular schedule. Doubling up to compensate for a missed dose can increase the risk of adverse events and should be avoided.

Consistent timing-for example, setting a daily alarm-helps prevent accidental omission. When travelling across time zones, maintain the same interval between doses rather than aligning with local clock time, thereby preserving therapeutic steadiness.

Understanding Side Effects and How to Manage Them

Most patients tolerate Arcoxia well, yet some experience adverse effects rooted in its pharmacology. By sparing COX-1, the medication reduces gastric irritation, but COX-2 inhibition can still compromise renal prostaglandin production, occasionally leading to fluid retention, increased blood pressure, or mild decreases in kidney function. Monitoring blood pressure and renal indices during the first few weeks of therapy is advisable.

Headache, dizziness, or transient visual disturbances may arise from subtle prostaglandin shifts within the central nervous system. Staying hydrated, avoiding alcohol excess, and rising slowly from seated positions can mitigate these sensations.

Rarely, serious cardiovascular events such as myocardial infarction or stroke have been reported, particularly in patients with pre-existing risk factors. Any sudden chest pain, shortness of breath, or unilateral weakness warrants immediate medical attention.

If you notice persistent abdominal pain, black or tarry stools, or unexplained swelling of the ankles, contact your healthcare provider promptly, as these signs may indicate gastrointestinal bleeding or fluid overload.

Buying Arcoxia from Our Online Pharmacy

Why Choose Our Service?

Our online pharmacy streamlines access to prescription-only medicines, delivering them at a fraction of the cost typically quoted in retail outlets. Discreet ordering and secure payment protect your privacy while ensuring you receive authentic medication.

Quality & Safety

We partner with licensed international pharmacies that operate under stringent regulatory frameworks recognized by the World Health Organization. Each batch of Arcoxia is verified against the manufacturer’s batch-release specifications before shipment, guaranteeing purity and potency.

Pricing & Access

Because etoricoxib is available as a generic, we can offer prices close to the manufacturing cost, often 30 %-45 % lower than brand-name equivalents. Should you require alternative COX-2 inhibitors-such as celecoxib or parecoxib-we also stock those options for comparison.

Discreet Delivery

Orders are packaged in unbranded, bubble-wrapped envelopes to safeguard the tablets and preserve confidentiality. Standard airmail typically arrives within three weeks, while express shipping can be completed in about seven days, both with tracking available through our platform.

Frequently Asked Questions

• How quickly does Arcoxia start to relieve pain? Analgesic effect usually becomes noticeable within 1-2 hours after ingestion, with peak benefit around 4 hours. The long half-life sustains relief for up to 24 hours.

• Can I use Arcoxia together with other NSAIDs for stronger pain control? Combining two NSAIDs increases the risk of gastrointestinal bleeding and renal impairment without providing additional analgesia. Discuss alternative adjuncts, such as acetaminophen, with your physician instead.

• Is it safe to take Arcoxia while on anticoagulant therapy? Although COX-2 selectivity reduces platelet inhibition, the concurrent use of anticoagulants may still elevate bleeding risk. Your doctor should evaluate the balance between pain management and anticoagulation.

• Will Arcoxia affect my blood pressure? COX-2 inhibition can lead to modest fluid retention, potentially raising systolic pressure by a few mm Hg. Routine blood-pressure checks are recommended, especially during the initial treatment phase.

• Do I need to stop Arcoxia before surgery? For most surgeries, discontinuation 24-48 hours beforehand is advised to minimise bleeding risk. Your surgeon will provide a specific timeframe based on the procedure.

• Can I switch from a non-selective NSAID to Arcoxia without a wash-out period? A brief overlap is generally unnecessary; however, if you have been taking high-dose ibuprofen, a 24-hour gap can reduce the chance of additive renal stress.

• Is Arcoxia appropriate for chronic low-back pain without a specific diagnosis? While some clinicians prescribe it off-label for nonspecific back pain, evidence is limited. Consider physical therapy or muscle relaxants first, reserving COX-2 inhibition for cases with proven inflammatory components.

• What should I do if I miss a dose? Take the missed tablet as soon as you remember if more than half a dosing interval remains; otherwise, skip it and continue with the next scheduled dose. Do not double the dose.

• Are there any dietary restrictions while taking Arcoxia? No specific foods must be avoided, but excessive alcohol can increase gastric irritation and should be limited. Maintaining adequate hydration supports renal clearance of the drug.

• How does Arcoxia compare to celecoxib in terms of cardiovascular risk? Both agents share a class-related risk profile, though individual studies suggest slightly different hazard ratios. The choice often hinges on dosing convenience, cost, and patient tolerance.

• Can I use Arcoxia during a flare of ulcerative colitis? COX-2 inhibitors may exacerbate inflammatory bowel disease in some patients. Discuss alternatives with your gastroenterologist before initiating therapy.

Glossary

Cyclo-oxygenase-2 (COX-2)

An inducible enzyme that converts arachidonic acid into prostaglandins during inflammation, contributing to pain, swelling, and fever.

Prostaglandins

Lipid compounds that act locally to amplify inflammatory signals, sensitize nerve endings, and promote vasodilation.

Half-life

The time required for the plasma concentration of a drug to decrease by 50 %; for etoricoxib, approximately 22 hours.

Bioequivalence

A regulatory standard indicating that a generic product delivers the same amount of active ingredient into the bloodstream as the reference brand, within an accepted variance.

Renal prostaglandins

Substances produced by the kidneys that help maintain blood flow; inhibition can affect fluid balance and kidney function.

Disclaimer

The information presented about Arcoxia is intended for general educational purposes and does not substitute professional medical consultation. Treatment decisions, including any off-label applications, should be made under the guidance of a qualified healthcare provider. Readers are presumed to be adults capable of making informed health choices. Our online pharmacy provides access to Arcoxia for individuals who may encounter limited availability, insurance restrictions, or cost barriers through conventional channels. Always discuss with your physician before initiating, modifying, or discontinuing any medication.

External Resources about Arcoxia

• ARCOXIA TABLET 60 mg Medication Singapore | ARCOXIA TABLET 60 mg Medication | Shim Clinic
• Arcoxia® 60mg Tablets Arcoxia® 90mg Tablets Arcoxia® 120mg …
• Arcoxia: Uses, Dosage, Side Effects, Food Interaction & FAQ
• Arcoxia oral tablets: Quick facts, FAQs, Side effects, Warnings | فارماسيا
• Package leaflet: Information for the user - medicines