Dapoxetine Medications
Dapoxetine is a serotonin reuptake inhibitor designed for rapid onset and short duration. It is indicated for the management of premature ejaculation.
Buy Dapoxetine Medications
About Dapoxetine
Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) specifically developed for the treatment of premature ejaculation (PE) in adult men. First authorized by the European Medicines Agency in 2009, the drug quickly became a cornerstone therapy for men who experience ejaculation within one minute of vaginal penetration or who cannot control ejaculation on demand. By blocking the serotonin transporter, Dapoxetine raises synaptic serotonin levels, which prolongs the ejaculatory latency without the sustained antidepressant effects associated with traditional SSRIs. The medication is marketed under brand names such as Priligy and Priligy 30 mg, and it is widely available in generic form through our online pharmacy. Although primarily indicated for PE, clinicians occasionally reference Dapoxetine in research on mood disorders, but such off-label use remains limited and not formally endorsed.
What is Dapoxetine?
Dapoxetine belongs to the class of selective serotonin reuptake inhibitors, a group best known for treating depression and anxiety. The European Medicines Agency (EMA) granted its first approval in 2009 for the indication of premature ejaculation, and subsequent updates have confirmed its safety profile for repeated use in men aged 18 years and older. The drug’s core molecular action involves reversible inhibition of the serotonin transporter (SERT), which temporarily elevates serotonin concentrations at the neuromuscular junction of the penile sensory nerves. This surge slows the ejaculatory reflex, granting men greater control over sexual climax. Dapoxetine is sold both as the branded tablet Priligy and as a generic formulation, all of which are stocked through our platform.
How Dapoxetine Works
Mechanism of Action
Dapoxetine selectively blocks SERT, preventing reuptake of serotonin into presynaptic neurons. The resulting increase in extracellular serotonin modulates the spinal ejaculatory centers, delaying the onset of emission and expulsion phases.
Therapeutic Effects
By prolonging serotonergic signaling, Dapoxetine extends intravaginal ejaculatory latency time (IELT). Clinical studies show median IELT improvements of 2-3 minutes compared with baseline, providing a measurable benefit for men with PE.
Onset and Duration
Peak plasma concentrations occur 1-2 hours after oral administration, aligning with the recommended dosing window of 1-2 hours before sexual activity. The half-life averages 1.5 hours, and the drug is effectively cleared within 24 hours, allowing for on-demand use without accumulation.
Approved Uses and Applications
Approved Indications
- Premature ejaculation in adult men, defined by ejaculation occurring within ≤ 1 minute of vaginal penetration or by the inability to delay ejaculation on demand. The EMA and several Asian regulatory agencies endorse this indication.
Off-Label Uses
- Adjunctive treatment of depressive symptoms in research settings has been explored, but Dapoxetine is not officially approved for mood disorders. Clinicians should consider that such applications fall outside regulatory endorsement.
Clinical Efficacy
A double-blind, placebo-controlled trial published in The New England Journal of Medicine reported a 73 % increase in IELT after four weeks of 30 mg Dapoxetine, with a further 28 % gain when the dose was escalated to 60 mg. Long-term extension studies in Lancet demonstrated sustained efficacy and tolerability over a 12-month period.
Buying Dapoxetine from Our Online Pharmacy
Why Choose Our Service
Accessing Dapoxetine can be challenging when local pharmacies lack sufficient stock or when insurance formularies restrict coverage. Our online pharmacy bridges that gap, offering discreet, reliable delivery to Singaporean addresses.
Brand Names and Generic Options
- Priligy 30 mg - branded, premium packaging.
- Priligy 60 mg - higher strength for men tolerating the lower dose.
- Generic Dapoxetine 30 mg - cost-effective, identical active ingredient.
- Generic Dapoxetine 60 mg - same efficacy at a reduced price point.
Quality & Safety
All products are sourced from licensed international pharmacies that comply with WHO Good Manufacturing Practices and are verified by our pharmacy service.
Pricing & Access
Generic tablets typically cost 30 % less than branded equivalents, and we extend a lifetime 10 % discount on all reorders.
Discreet Delivery
Express shipping arrives in approximately 7 days, while standard delivery takes up to 3 weeks. Each package is wrapped in neutral, tamper-evident material to protect privacy.
Dosing, Formulations & Administration
Available Formulations
- Tablets: 30 mg and 60 mg immediate-release strengths.
Typical Dosing Ranges
For men with PE, treatment often starts at 30 mg taken 1-2 hours before sexual activity. If the initial dose is well tolerated, clinicians may increase to 60 mg to achieve greater latency.
Administration Guidelines
- Consume with a glass of water; food does not markedly affect absorption, but a light meal may reduce occasional nausea.
- Avoid alcohol excess, as it can amplify dizziness.
- Do not exceed one dose per 24-hour period.
A qualified healthcare professional must tailor the exact dose to individual health status, concomitant medications, and treatment goals.
Safety Profile & Considerations
Common Side Effects
- Nausea (≈ 15 % of users)
- Dizziness (≈ 12 %)
- Headache (≈ 10 %)
- Insomnia (≈ 8 %)
- Diarrhoea (≈ 5 %)
These effects are typically mild and resolve within a few days of continued therapy.
Serious Adverse Events
- Suicidal ideation - rare but requires immediate evaluation.
- Syncope - especially in men with underlying cardiac disorders.
- Serotonin syndrome - precipitated by concurrent serotonergic agents.
Contraindications
- Severe hepatic impairment
- Concurrent use of monoamine oxidase inhibitors (MAOIs)
- Significant cardiovascular disease (e.g., uncontrolled hypertension, recent myocardial infarction)
Drug Interactions
- CYP2D6 inhibitors (e.g., paroxetine, fluoxetine) increase Dapoxetine plasma levels, raising the risk of adverse effects.
- Other serotonergic drugs (SSRIs, SNRIs, tramadol) heighten the potential for serotonin syndrome.
Special Populations
- Pregnancy & breastfeeding: Not indicated; safety data are lacking.
- Older adults: Dose adjustments may be needed for hepatic or renal decline.
- Renal/hepatic impairment: Initiate at the lower 30 mg dose and monitor closely.
Professional evaluation remains essential before initiating therapy.
Frequently Asked Questions
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How does Dapoxetine differ from other SSRIs used for depression? Dapoxetine has a much shorter half-life (≈ 1.5 hours) and is designed for on-demand use, whereas traditional SSRIs require daily dosing and accumulate over weeks.
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How long does Dapoxetine take to work for premature ejaculation? Peak effect occurs 1-2 hours after ingestion, so men typically experience delayed ejaculation within that window.
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What should I do if I experience nausea after taking Dapoxetine? Nausea is common; taking the tablet with a light meal or adjusting the dose to 30 mg may alleviate symptoms. Persistent vomiting warrants medical review.
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Can I take Dapoxetine with alcohol? Moderate alcohol consumption is permissible, but excessive intake can enhance dizziness and lower blood pressure, increasing the risk of syncope.
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Is Dapoxetine safe for men with hypertension? Mild hypertension is not an absolute contraindication, but uncontrolled high blood pressure requires physician assessment before use.
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What foods should I avoid while using Dapoxetine? No specific dietary restrictions exist, though high-fat meals may delay absorption slightly; a balanced diet is recommended.
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Does Dapoxetine interact with over-the-counter supplements? Supplements containing St. John’s wort or other serotonergic compounds can raise serotonin levels and should be discussed with a healthcare provider.
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How does Dapoxetine compare with sildenafil for sexual performance? Sildenafil targets erectile function by enhancing blood flow, while Dapoxetine focuses on ejaculatory control. They address different aspects of sexual health and are not interchangeable.
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What information should I provide my doctor when discussing Dapoxetine?
- Complete medical history, including cardiovascular and liver conditions.
- All current prescription, over-the-counter, and herbal medications.
- Specific concerns about ejaculation latency and any prior treatments tried.
- Any history of mood disorders or suicidal thoughts.
Disclaimer
The information provided about Dapoxetine is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Dapoxetine for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Dapoxetine.
