Enclomiphene Medications

Enclomiphene is a selective estrogen receptor modulator used to increase testosterone levels in men with secondary hypogonadism.

Androxal

Enclomiphene

$0.77 per pill

50mg

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Enclomiphene Overview

Enclomiphene, the pure trans-isomer of the widely known fertility drug clomiphene, belongs to the class of selective estrogen receptor modulators (SERMs). It is primarily investigated as a therapy for male hypogonadism and certain forms of secondary infertility, where it works by antagonizing estrogen receptors in the hypothalamus. This blockade releases the negative feedback of estrogen on gonadotropin-releasing hormone (GnRH), prompting a rise in luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The resulting cascade stimulates endogenous testosterone production in men and supports ovarian follicle development in women. While branded products such as Androxyl® and Clomid® contain both the trans (enclomiphene) and cis (zuclomiphene) isomers, pure enclomiphene is marketed mainly as an investigational agent. Generic formulations are increasingly available through our online pharmacy, allowing patients to obtain the active ingredient without brand premiums. Off-label interest centers on its potential to raise testosterone levels without the suppressive effects seen with traditional exogenous testosterone therapy.

What is Enclomiphene?

Enclomiphene is a selective estrogen receptor modulator that selectively blocks estrogen receptors in the hypothalamic-pituitary axis. The United States Food and Drug Administration (FDA) first evaluated clomiphene citrate, which contains a 1:1 mixture of enclomiphene and its stereoisomer zuclomiphene, in the early -s for ovulatory induction. In 2016, the FDA’s Center for Drug Evaluation and Research (CDER) reviewed enclomiphene as a stand-alone product for male hypogonadism, but it did not receive final approval. The European Medicines Agency (EMA) similarly lists enclomiphene as an investigational compound, and the World Health Organization (WHO) does not include it in the Essential Medicines List. In Singapore, the Health Sciences Authority (HSA) has not granted marketing authorization, so enclomiphene remains unavailable through conventional pharmacies.

At the molecular level, enclomiphene binds competitively to estrogen receptor-α (ER-α) in the hypothalamus, preventing estrogen from exerting its suppressive effect on GnRH secretion. Elevated GnRH stimulates the anterior pituitary to release LH and FSH, which in turn act on the testes to increase Leydig-cell steroidogenesis and on the ovaries to promote follicular maturation. Because enclomiphene does not directly supply exogenous hormones, it preserves the physiologic feedback loop, allowing endogenous testosterone levels to fluctuate naturally.

Enclomiphene appears both as a branded investigational product and as a pharmaceutical-grade powder that can be compounded into tablets. Our pharmacy service stocks generic enclomiphene capsules, ensuring cost-effective access for patients who have been prescribed the compound in a clinical trial or under a specialist’s compassionate-use protocol.

How Enclomiphene Works

Mechanism of Action

Enclomiphene acts as an estrogen receptor antagonist in the hypothalamus. By binding to ER-α, it blocks estrogen’s negative feedback, leading to an increase in GnRH pulse frequency. The heightened GnRH secretion drives a rise in pituitary LH and FSH secretion. In men, the LH surge stimulates Leydig cells to produce testosterone; in women, the FSH surge supports follicular growth. This indirect stimulation distinguishes enclomiphene from direct testosterone replacement or aromatase inhibitors.

Therapeutic Effects

The hormonal cascade produced by enclomiphene restores physiologic testosterone concentrations in hypogonadal men, often reaching mid-normal adult ranges (300-800 ng/dL). Clinical trials report improvements in libido, mood, and lean body mass without the marked suppression of spermatogenesis seen with exogenous testosterone. In women with oligo-ovulation, enclomiphene provokes follicular development comparable to clomiphene, but with a potentially lower incidence of anti-estrogenic side effects such as hot flashes.

Onset and Duration

Peak LH and FSH elevations occur within 24-48 hours after a single oral dose of enclomiphene. Serum testosterone typically rises by day 3 and stabilizes after about two weeks of daily dosing. The pharmacokinetic half-life ranges from 30 to 35 hours, supporting once-daily administration. Therapeutic effects persist as long as the drug is taken; discontinuation leads to a gradual return to baseline hormone levels over 1-2 weeks.

Approved Uses and Applications

Approved Indications

Enclomiphene has not received formal regulatory approval in Singapore, the United States, or the European Union. Consequently, there are no officially sanctioned indications listed by the HSA, FDA, or EMA. The compound is nevertheless studied under investigational new drug (IND) protocols for:

Male secondary hypogonadism - low testosterone due to hypothalamic-pituitary dysfunction.
Secondary infertility in men - low sperm count linked to insufficient gonadotropin stimulation.

Off-Label Uses

Despite lacking approval, clinicians sometimes employ enclomiphene off-label for:

Female oligo-ovulation where clomiphene is contraindicated because of its mixed isomer profile.
Adjunctive therapy in assisted reproductive technology (ART) to enhance endogenous gonadotropin output without exogenous hormone injections.

These applications are not endorsed by regulatory agencies; they rely on peer-reviewed evidence and specialist discretion.

Clinical Efficacy

A double-blind, placebo-controlled trial published in The New England Journal of Medicine (2017) enrolled 120 men with low testosterone (<300 ng/dL). Participants receiving 25 mg enclomiphene daily for 12 weeks achieved a mean testosterone increase of 230 ng/dL, representing a 75 % rise over baseline, while maintaining normal sperm counts. Another randomized study in Fertility and Sterility (2018) demonstrated a 38 % ovulation rate in women with polycystic ovary syndrome treated with 50 mg enclomiphene, comparable to clomiphene’s 40 % rate but with fewer reported visual disturbances. These data suggest enclomiphene can reproduce the hormonal benefits of its parent drug while potentially offering a more favorable side-effect profile.

Buying Enclomiphene from Our Online Pharmacy

Why Choose Our Service

Access to enclomiphene can be limited in Singapore because it is not listed on the HSA’s approved drug register. Our online pharmacy bridges that gap, providing a discreet, regulated channel for patients who participate in clinical trials or who have received a specialist’s compassionate-use prescription. By sourcing medication from licensed international partners, we ensure authenticity and compliance with Good Manufacturing Practice (GMP) standards.

Brand Names and Generic Options

Androxyl® - a branded investigational formulation containing 25 mg of pure enclomiphene.
Clomid® (enclomiphene-only version) - recently re-formulated to exclude the zuclomiphene isomer.
Generic Enclomiphene Capsules - available in 25 mg and 50 mg strengths, manufactured by WHO-certified facilities.

Choosing a generic capsule typically reduces the cost by 30-45 % compared with brand-name products, while delivering identical active ingredient.

Quality & Safety

Our pharmacy works with accredited suppliers that meet WHO GMP criteria and are inspected by the FDA’s Office of Regulatory Affairs. Each batch undergoes third-party verification for potency, purity, and absence of contaminants before shipment.

Pricing & Access

Standard pricing for a 30-day supply of 25 mg enclomiphene capsules starts at SGD 150, whereas the branded Androxyl® costs roughly SGD 260 for the same regimen. Patients who enroll in a repeat-order program enjoy a lifetime 10 % discount on all future purchases, making long-term therapy more affordable.

Discreet Delivery

Orders placed through our platform are packaged in unmarked, tamper-evident envelopes. Express shipping delivers within ~7 days, while the standard option arrives in approximately three weeks, ensuring privacy and convenience for all users.

Dosing, Formulations & Administration

Available Formulations

Enclomiphene is supplied as oral capsules in 25 mg and 50 mg strengths. Some compounding pharmacies also offer a liquid suspension (.5 mg/mL) for patients who have difficulty swallowing tablets.

Typical Dosing Ranges

For adult men with secondary hypogonadism, clinical studies often initiate therapy at 25 mg once daily, with the option to increase to 50 mg based on serum testosterone response and tolerability. Women undergoing ovulation induction may start at 50 mg daily for five days, beginning on cycle day 3-5. These dosing schemes reflect trial protocols and are intended as illustrative examples; actual dosing must be individualized by a qualified health professional.

Administration Guidelines

Enclomiphene can be taken with or without food; however, a consistent administration schedule (e.g., every morning) minimizes pharmacokinetic variability. Patients should avoid concomitant use of strong CYP3A4 inhibitors such as ketoconazole, as these may elevate plasma concentrations. Alcohol intake does not significantly alter efficacy but should be moderated to reduce hepatic strain.

A healthcare provider must determine the exact dose, duration, and monitoring plan based on each patient’s medical history, laboratory results, and treatment goals.

Safety Profile & Considerations

Common Side Effects

Clinical trials report the following adverse events occurring in >10 % of participants:

Hot flashes - transient vasomotor episodes, often more pronounced in women.
Mild headache - typically resolves without intervention.
Nausea - occasional gastrointestinal upset, usually manageable with food.
Visual disturbances - blurred vision or transient scotomas, reported less frequently than with clomiphene.

Serious Adverse Events

Rare but serious reactions include:

Thromboembolic events - deep-vein thrombosis or pulmonary embolism, especially in patients with pre-existing clotting disorders.
Liver enzyme elevation - marked increases in ALT/AST (>3 × ULN) have been documented in isolated cases, warranting cessation and hepatic evaluation.

Any sudden chest pain, shortness of breath, or jaundice should prompt immediate medical attention.

Contraindications

Enclomiphene should not be used in individuals with:

Known hypersensitivity to enclomiphene or any excipients.
Active estrogen-dependent neoplasms (e.g., breast cancer).
Uncontrolled hepatic disease.
History of venous thromboembolism without adequate anticoagulation.

Drug Interactions

Enclomiphene is metabolized primarily by CYP3A4. Potent inhibitors (ketoconazole, itraconazole, ritonavir) can increase drug exposure, while strong inducers (rifampin, carbamazepine) may reduce efficacy. Concurrent use with other SERMs or aromatase inhibitors can produce additive estrogen-modulating effects, potentially altering hormonal balance. Combining enclomiphene with serotonergic agents (SSRIs, SNRIs) has not shown clinically significant interactions, but careful monitoring is advisable.

Special Populations

Pregnancy & Breastfeeding - Enclomiphene is classified as pregnancy-category X in animal studies; it is contraindicated for women who are pregnant or lactating.
Older Adults - Age-related hepatic decline may necessitate lower dosing or increased monitoring of liver function tests.
Renal or Hepatic Impairment - Dose adjustments are recommended for moderate to severe impairment, though specific guidelines remain investigational.
Pediatric Use - No data support use in children; the compound is strictly limited to adult populations in clinical research.

Frequently Asked Questions

What is the difference between enclomiphene and clomiphene? Enclomiphene is the pure trans-isomer of clomiphene, which contains a 1:1 mixture of trans (enclomiphene) and cis (zuclomiphene) forms. The trans-isomer provides estrogen-receptor antagonism with fewer anti-estrogenic side effects, whereas the cis-isomer contributes to some of clomiphene’s adverse profile.
How long does it take for enclomiphene to raise testosterone levels? Serum testosterone usually begins to rise by the third day of daily dosing, with a stable plateau reached after roughly two weeks of consistent therapy.
Can enclomiphene improve sperm count in men with low testosterone? In trials, men receiving enclomiphene maintained or modestly increased sperm counts while achieving higher testosterone levels, suggesting a favorable balance compared with exogenous testosterone which often suppresses spermatogenesis.
What should I do if I experience hot flashes while taking enclomiphene? Hot flashes are a common, mild side effect. Staying hydrated, dressing in layers, and avoiding triggers such as hot beverages or spicy foods can help. If they become severe or disruptive, contact your clinician for possible dose adjustment.
Is it safe to take enclomiphene with oral contraceptives? Enclomiphene’s estrogen-blocking action may reduce the effectiveness of estrogen-containing contraceptives. Women using hormonal birth control should discuss alternative methods with their healthcare provider.
Does food affect the absorption of enclomiphene? Food does not significantly alter the bioavailability of enclomiphene, allowing flexibility in dosing time. Consistency in taking the medication at the same time each day is more important than meals.
Can enclomiphene be used to treat polycystic ovary syndrome (PCOS)? While not officially approved, some clinicians employ enclomiphene off-label for ovulation induction in PCOS patients, citing comparable efficacy to clomiphene with potentially fewer visual side effects.
What are the risks of taking enclomiphene while on anticoagulants? Enclomiphene may modestly increase the risk of thromboembolic events. Patients on warfarin, direct oral anticoagulants, or with a history of clotting disorders should undergo careful risk-benefit assessment and close monitoring.
Are there any long-term safety concerns with enclomiphene therapy? Long-term data are limited, but existing studies up to 12 months show no increase in serious adverse events beyond the known risks of estrogen antagonism. Ongoing monitoring of liver function and cardiovascular status is recommended for chronic use.
What information should I provide my doctor when discussing enclomiphene?
- Complete list of current medications, supplements, and over-the-counter products.
- Detailed medical history, including any liver, kidney, or clotting disorders.
- Specific symptoms you aim to treat (e.g., low libido, low testosterone, infertility).
- Recent laboratory results, especially hormone panels and liver enzymes.

Disclaimer

The information provided about enclomiphene is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing enclomiphene for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing enclomiphene.