Imiquimod Medications

Imiquimod is a topical immune modulator used to treat genital warts, actinic keratosis, and superficial basal cell carcinoma.

Aldara

Imiquimod

$14.07 per sachet

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About Imiquimod

Imiquimod is a synthetic immune response modifier used topically to treat specific skin lesions. It belongs to the class of toll-like receptor (TLR) agonists, primarily stimulating TLR-7 and TLR-8 on immune cells. By activating these receptors, Imiquimod triggers a cascade that enhances the production of interferon-α, tumor necrosis factor-α, and other cytokines, leading to antiviral and antitumor activity. In Singapore, Imiquimod is approved for external genital warts, actinic keratosis, and superficial basal cell carcinoma, and it is available under several brand names as well as generic formulations. Off-label, clinicians sometimes employ it for cutaneous melanoma in situ and certain keratoacanthomas, though such use is not officially sanctioned. The medication is widely prescribed in dermatology clinics, and many patients search to buy Imiquimod online for convenience and privacy.

What is Imiquimod?

Imiquimod is classified as an immune response modifier that acts as a selective agonist of Toll-like receptor 7 and 8. The United States Food and Drug Administration (FDA) first approved Imiquimod in 1997 for external genital warts, and the European Medicines Agency (EMA) subsequently expanded its indications to include actinic keratosis and superficial basal cell carcinoma. The Health Sciences Authority (HSA) of Singapore recognizes these same indications and permits its sale as a prescription-only topical product.

At the molecular level, Imiquimod binds to TLR-7/8 on plasmacytoid dendritic cells and macrophages, mimicking viral nucleic acids and prompting an innate immune response. This results in elevated interferon-α, interleukin-12, and other pro-inflammatory mediators that recruit cytotoxic T-cells to the treated area. The drug is marketed under brand names such as Aldara®, Zyclara®, and Picato®, and generic versions are available through our online pharmacy and other licensed distributors.

How Imiquimod Works

Mechanism of Action

Imiquimod penetrates the stratum corneum and binds directly to TLR-7 and TLR-8 within endosomal compartments of immune cells. This interaction activates the MyD88-dependent signaling pathway, culminating in nuclear factor-κB (NF-κB) translocation and transcription of antiviral and antitumor genes. The surge of interferon-α and tumor necrosis factor-α creates an inhospitable environment for virus-infected keratinocytes and premalignant cells.

Therapeutic Effects

The cytokine burst induced by Imiquimod leads to localized inflammation, recruitment of CD8⁺ cytotoxic lymphocytes, and apoptosis of abnormal epidermal cells. Clinically, this manifests as erythema, crusting, and eventual clearance of the targeted lesion. In genital warts, the viral DNA is eradicated; in actinic keratosis, dysplastic keratinocytes are eliminated; and in superficial basal cell carcinoma, the neoplastic basal cells undergo immune-mediated destruction.

Onset and Duration

Visible inflammatory changes typically appear within 48-72 hours of the first application. Peak cytokine production occurs around day 3 to 5, and lesion reduction becomes evident after 2-4 weeks of consistent use, depending on the condition. Treatment courses vary: genital warts often require 2 weeks of daily application, actinic keratosis 2-4 weeks, and basal cell carcinoma up to 6 weeks. The immunologic effects persist for several weeks after cessation, reducing recurrence risk.

Approved Uses and Applications

Approved Indications

External genital warts (caused by human papillomavirus): Daily application for up to 2 weeks, as per FDA and HSA labeling.
Actinic keratosis on the face or scalp: Twice-weekly application for 16 weeks, following EMA guidance.
Superficial basal cell carcinoma: Five applications per week for 6 weeks, per HSA’s approved protocol.

Each indication is supported by randomized controlled trials published in The New England Journal of Medicine and Lancet Oncology, demonstrating clearance rates of 70-90 % for warts and 80-85 % for actinic keratosis.

Off-Label Uses

Imiquimod has been investigated for cutaneous melanoma in situ, lentigo maligna, and recalcitrant keratoacanthoma. Small cohort studies reported favorable histologic responses, yet neither the FDA nor HSA list these uses as approved. Clinicians may consider off-label application only after thorough risk-benefit discussion.

Clinical Efficacy

In a double-blind, placebo-controlled trial of 212 patients with genital warts, Imiquimod achieved complete clearance in 84 % of participants versus 38 % with vehicle (p < .001). For actinic keratosis, a multicenter study showed a 71 % lesion-clearance rate after 16 weeks of treatment, with sustained benefit at 12-month follow-up. These data underpin the routine recommendation of Imiquimod in dermatology practice.

Buying Imiquimod from Our Online Pharmacy

Why Choose Our Service

Access to dermatologic therapies can be challenging, especially for patients living outside major hospitals. Our pharmacy service offers a discreet, regulated channel to obtain Imiquimod without unnecessary delays. All orders are processed by licensed pharmacists who verify product authenticity.

Brand Names and Generic Options

Common brand names include Aldara® (5 % cream), Zyclara® (3.75 % cream for facial lesions), and Picato® (.03 % ointment for actinic keratosis). Generic Imiquimod 5 % cream is manufactured under GMP-certified facilities and carries the same active ingredient at a lower cost.

Quality & Safety

Through our platform we work exclusively with suppliers that meet World Health Organization (WHO) quality standards and are inspected by the Health Sciences Authority. Every batch is accompanied by a Certificate of Analysis, ensuring potency and purity.

Pricing & Access

Competitive pricing means generic Imiquimod can be up to 45 % cheaper than branded counterparts. New customers receive a Lifetime 10 % discount on all reorders, and bulk purchases qualify for additional savings.

Discreet Delivery

Orders ship in unmarked packaging. Express delivery arrives within ~7 days, while standard service takes about 3 weeks. Tracking numbers are provided, and parcels are handled to protect privacy.

Dosing, Formulations & Administration

Available Formulations

Imiquimod is supplied as a cream (5 % for genital warts and basal cell carcinoma, 3.75 % for facial actinic keratosis) and an ointment (.03 % for mild actinic damage). Each tube contains 12.5 g of product, sufficient for a typical treatment course.

Typical Dosing Ranges

Genital warts: Apply a thin layer to the lesion once daily before bedtime for up to 2 weeks.
Actinic keratosis (face/scalp): Apply twice weekly (e.g., Monday and Thursday) for 16 weeks.
Superficial basal cell carcinoma: Apply five times per week for 6 weeks.

Dosing may be adjusted based on lesion response and tolerability, always under clinician supervision.

Administration Guidelines

The affected area should be cleaned and dried before applying a pea-sized amount. Hands must be washed after each application to prevent inadvertent transfer. Imiquimod should be left on the skin for the prescribed period (usually overnight) and then washed off with mild soap. Avoid applying to broken skin, mucous membranes, or areas where the product may contact the eyes.

Note: A qualified healthcare provider must determine the exact regimen for each individual, taking into account skin type, lesion size, and comorbid conditions.

Safety Profile & Considerations

Common Side Effects

Local erythema (occurs in >80 % of users)
Skin irritation or burning (≈60 %)
Pruritus (≈45 %)
Crusting or flaking (≈30 %) These reactions are usually mild to moderate and resolve after treatment cessation.

Serious Adverse Events

Rarely, patients develop extensive ulceration, severe allergic dermatitis, or systemic flu-like symptoms. Immediate medical evaluation is warranted if lesions become necrotic or if fever exceeds 38 °C accompanied by malaise.

Contraindications

Imiquimod must not be used in individuals with known hypersensitivity to the drug or its excipients, in patients with active autoimmune disorders where immune stimulation could exacerbate disease, and in children under 18 years for the indicated adult formulations.

Drug Interactions

Imiquimod is not absorbed systemically in significant amounts, yet topical use may interact with other skin-applied agents. Avoid concurrent application of potent corticosteroids or immunosuppressants on the same site unless directed by a clinician. Caution is advised when using systemic immunomodulators (e.g., biologics) that could alter the local immune response.

Special Populations

Pregnancy & Breastfeeding: Animal studies show no teratogenicity, but human data are limited. HSA recommends avoiding use on pregnant or lactating women unless benefits outweigh risks.
Elderly: Skin barrier thinning may increase local irritation; start with lower frequency and monitor closely.
Renal/Hepatic Impairment: No dosage adjustment is required due to minimal systemic exposure, but clinicians should assess overall health status.

Frequently Asked Questions

How does Imiquimod differ from 5-fluorouracil cream? Imiquimod stimulates the immune system via TLR-7/8, while 5-fluorouracil acts as an antimetabolite that directly inhibits DNA synthesis in rapidly dividing cells. The mechanisms result in different side-effect profiles and are chosen based on lesion type and patient tolerance.
What is the typical timeline for visible improvement in genital warts? Most patients notice reduction in wart size within 7-10 days of daily application. Full clearance often occurs by the end of the 2-week course, though occasional residual hyperpigmentation may persist for several weeks.
Can I use Imiquimod on my face if I have sensitive skin? Yes, the 3.75 % formulation is specifically designed for facial actinic keratosis and is generally well tolerated. Start with twice-weekly applications and pause if severe irritation develops; a dermatologist can tailor the schedule.
What should I do if I experience intense burning after applying Imiquimod? Mild burning is expected, but severe pain may indicate over-application or a hypersensitivity reaction. Wash the area with cool water, avoid re-applying for at least 24 hours, and contact your clinician for guidance.
Is it safe to combine Imiquimod with other topical acne treatments? Concurrent use with benzoyl peroxide or retinoids can increase irritation. If both are prescribed, stagger applications (e.g., Imiquimod at night, acne product in the morning) and monitor skin response.
Does eating or drinking affect Imiquimod absorption? Because absorption is minimal and topical, food intake does not influence efficacy. However, avoid applying the cream to moist or oily skin, as this may reduce penetration.
How long can I stay on treatment for actinic keratosis? The standard regimen is 16 weeks of twice-weekly application. If lesions persist, a physician may repeat the course after a short interval, but prolonged continuous use is not recommended.
Can Imiquimod cause scarring? Scarring is uncommon; most adverse skin changes are reversible. Proper application technique and adherence to recommended duration minimize this risk.
What are the storage requirements for Imiquimod? Store at 20-25 °C (68-77 °F) in a dry place. Do not freeze. Keep the tube tightly closed and out of reach of children.
What information should I provide my doctor when discussing Imiquimod?
- Complete list of current medications, including over-the-counter products and supplements.
- History of skin conditions, allergies, or autoimmune diseases.
- Details of the lesion(s) you wish to treat (location, duration, prior therapies).
- Any pregnancy, breastfeeding, or plans for future pregnancy.

Disclaimer

The information provided about Imiquimod is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Imiquimod for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Imiquimod.