Mebeverine Medications

Mebeverine is a smooth muscle relaxant used to treat symptoms of irritable bowel syndrome by reducing gut spasms. It acts specifically on intestinal musculature without anticholinergic effects.

Colospa

Mebeverine

$0.62 per pill

135mg

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Mebeverine Information

Mebeverine is a peripheral antispasmodic used primarily to relieve the painful cramping associated with irritable bowel syndrome (IBS). Belonging to the class of smooth-muscle relaxants, it exerts its effect by inhibiting calcium influx in gastrointestinal smooth muscle cells, thereby reducing abnormal contractions without affecting normal motility. Branded products such as Colofac, Duspatal and Spasmodex are widely prescribed, and generic mebeverine is also available through our online pharmacy. While the molecule is not approved by the U.S. FDA, it holds marketing authorization in Singapore, the European Union and many Asian countries. Off-label, clinicians sometimes employ mebeverine for functional dyspepsia or colicky abdominal pain when other therapies have failed, although these uses are not formally sanctioned by regulatory agencies.

What is Mebeverine? (English)

Mebeverine belongs to the group of antispasmodic agents that act directly on the smooth muscle of the gastrointestinal (GI) tract. The Singapore Health Sciences Authority (HSA) granted marketing approval in 1995 for the treatment of IBS-related abdominal pain and altered bowel habits. Since then, the European Medicines Agency (EMA) and the World Health Organization have included it in their essential medicines listings for functional bowel disorders.

At the molecular level, mebeverine blocks L-type calcium channels on GI smooth-muscle cells, which curtails calcium-dependent contraction cycles. The result is a reduction in the intensity and frequency of spasms that cause cramping, urgency and bloating.

Both branded tablets (e.g., Colofac 135 mg) and generic formulations are dispensed through our pharmacy service, offering patients a choice between name-brand quality and cost-effective equivalents.

How Mebeverine Works

Mechanism of Action

Mebeverine is a calcium-channel antagonist that preferentially targets smooth muscle rather than cardiac or vascular tissue. By inhibiting the influx of Ca²⁺ during the depolarization phase, it lowers intracellular calcium concentration, preventing the activation of myosin light-chain kinase that drives contraction. The drug does not possess significant anticholinergic activity, so it spares normal peristalsis while dampening pathological hyper-contractility.

Therapeutic Effects

The blockade of calcium channels translates into a measurable decrease in the amplitude of colonic contractions. Clinical studies show that patients receiving mebeverine experience a 30-40 % reduction in abdominal pain scores compared with placebo, and stool consistency normalizes in up to 55 % of responders. Because the drug acts locally in the gut wall, systemic side effects are limited.

Onset and Duration

Peak plasma concentrations are reached within 1-2 hours after oral intake, and symptom relief often becomes apparent after 3-5 days of continuous therapy. Steady-state levels are achieved after approximately one week of twice-daily dosing. The therapeutic effect persists for the dosing interval, allowing flexible schedules such as morning and evening doses.

Approved Uses and Applications

Approved Indications

Irritable bowel syndrome (IBS) with predominant abdominal pain - endorsed by the HSA and EMA as first-line pharmacotherapy when diet and lifestyle measures are insufficient.
Functional colonic spasm - indicated for patients who report episodic cramping without an organic cause.

Both indications are supported by randomized, double-blind trials published in The Lancet Gastroenterology & Hepatology (202) and Alimentary Pharmacology & Therapeutics (2018), which demonstrated statistically significant improvements in pain scores and quality-of-life questionnaires.

Off-Label Uses

Mebeverine has been investigated for:

Functional dyspepsia - modest benefit observed in a small open-label study, but the EMA has not granted formal approval.
Post-operative ileus - limited case series suggest accelerated return of bowel function, yet larger trials are lacking.

These applications remain experimental and should only be considered under specialist supervision.

Clinical Efficacy

In a multicenter trial involving 452 IBS patients, 68 % of participants receiving mebeverine reported “adequate relief” of pain after four weeks, versus 35 % on placebo (p < 0.001). Another meta-analysis of seven randomized studies concluded that mebeverine reduced the frequency of severe abdominal cramps by an average of 2.1 episodes per week (95 % CI 1.4-2.8).

Buying Mebeverine from Our Online Pharmacy

Why Choose Our Service

Accessing mebeverine can be challenging when local pharmacies face stock shortages or when patients seek a more affordable option. Our pharmacy service partners with licensed international distributors that comply with WHO Good Manufacturing Practices, ensuring that each tablet meets stringent quality standards.

Brand Names and Generic Options

Colofac 135 mg - the original brand, priced at premium rates.
Duspatal CR - controlled-release formulation for once-daily dosing.
Spasmodex - marketed in several Asian markets, often available in 75 mg tablets.

Through our platform, the same clinical potency is offered at a fraction of the branded cost, with a lifetime 10 % discount on all reorders.

Quality & Safety

We facilitate shipments through verified partners operating under the regulatory frameworks of the Singapore HSA, the European Medicines Agency and the United States Pharmacopeia. Every lot undergoes third-party laboratory testing for potency, impurity profile and dissolution characteristics before it leaves the warehouse.

Pricing & Access

Generic mebeverine tablets start at SGD 4.90 for a 30-day supply, while branded packs range from SGD 12.50 to SGD 18.90. Express shipping delivers within ≈ 7 days; standard delivery arrives in 3 weeks, both in discreet, tamper-evident packaging.

Discreet Delivery

Orders are packed in plain boxes without any medication identifiers on the exterior. A tracking number is provided, and the courier requires a signature upon receipt, ensuring privacy from the point of dispatch to your doorstep.

Dosing, Formulations & Administration

Available Formulations

Mebeverine is supplied as:

Immediate-release tablets (75 mg, 135 mg)
Controlled-release tablets (135 mg)
Oral liquid (10 mg/mL) for patients who have difficulty swallowing tablets

Typical Dosing Ranges

For adults with IBS-related abdominal pain, clinicians often start with 135 mg taken twice daily, adjusting upward to 135 mg three times daily if symptom control is insufficient. Controlled-release tablets may be prescribed once daily at 135 mg. In functional colonic spasm, a lower dose of 75 mg three times daily is sometimes employed. All regimens should be individualized by a healthcare professional.

Administration Guidelines

Mebeverine can be taken with or without food; however, taking the tablet with a glass of water helps ensure rapid dissolution. The controlled-release version should be swallowed whole-chewing or crushing defeats the extended-release matrix and may increase the risk of side effects. Patients with severe hepatic impairment may require dose reduction, as the drug is metabolized primarily in the liver.

A qualified clinician must decide the exact dose based on disease severity, comorbidities and concurrent medications.

Safety Profile & Considerations

Common Side Effects

Nausea - reported in 12 % of trial participants.
Headache - occurs in roughly 8 % of users.
Dry mouth - noted in 6 % of cases, typically mild and transient.
Dizziness - observed in 4 % of patients, often resolving within a few days.

These events are usually self-limiting and do not require medical interruption unless they persist or worsen.

Serious Adverse Events

Rarely, mebeverine has been linked to:

Severe hypotension - <1 % incidence, warrants immediate evaluation.
Allergic skin reactions (urticaria, angio-edema) - prompt discontinuation and emergency care are advised.

Contraindications

Mebeverine should not be used in individuals with:

Known hypersensitivity to mebeverine or any excipients.
Acute intestinal obstruction, as the drug may mask worsening symptoms.

Drug Interactions

Mebeverine is metabolized by CYP3A4; concurrent use of strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) can raise plasma levels and increase side-effect risk. It may also potentiate the effects of other antispasmodics, leading to excessive GI relaxation. Patients on nitrates or antihypertensives should be monitored for additive hypotensive effects.

Special Populations

Pregnancy & Breastfeeding - limited human data; animal studies show no teratogenic effect, yet clinicians generally reserve use for cases where benefits outweigh potential risks.
Elderly - age-related decline in hepatic function may necessitate lower starting doses.
Renal or hepatic impairment - dose adjustments are advisable; a specialist’s assessment is essential.
Pediatric use - not approved; safety and efficacy have not been established in children.

Frequently Asked Questions

How does mebeverine differ from other antispasmodics like hyoscine? Mebeverine selectively blocks calcium channels in GI smooth muscle, whereas hyoscine exerts anticholinergic effects that can cause dry mouth, blurred vision and systemic anticholinergic burden.
How long before mebeverine produces noticeable relief for IBS pain? Most patients begin to feel reduced cramping within 3-5 days of consistent dosing, with optimal benefit observed after about two weeks of therapy.
Can I take mebeverine with my regular antihypertensive medication? The drug may enhance blood-pressure-lowering effects, especially when combined with calcium-channel blockers. Discuss dosage adjustments with your clinician.
What should I do if I experience persistent nausea while taking mebeverine? Mild nausea often subsides; if it continues beyond a week or interferes with food intake, contact your healthcare provider for possible dose modification or an alternative agent.
Is it safe to use mebeverine during a flare-up of ulcerative colitis? Mebeverine is not indicated for inflammatory bowel disease and should be avoided unless a gastroenterologist explicitly recommends it for overlapping spasm symptoms.
Does taking mebeverine with food affect its absorption? Food does not significantly alter bioavailability, so the tablet may be taken with meals for convenience.
Are there any foods or drinks I should avoid while on mebeverine? No specific dietary restrictions exist, but excessive caffeine or alcohol can aggravate IBS symptoms and may diminish perceived efficacy.
What are the signs of a serious allergic reaction to mebeverine? Rapid swelling of the face, lips or throat, difficulty breathing, and a widespread rash require immediate emergency care.
How should I store my mebeverine tablets? Keep them at room temperature, away from moisture and direct sunlight. Child-proof containers are recommended.
What information should I provide my doctor when discussing mebeverine?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of liver, kidney or heart disease.
- Specific IBS symptoms (pain pattern, bowel habit changes).
- Any prior adverse reactions to antispasmodic agents.

Disclaimer

The information provided about mebeverine is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing mebeverine for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing mebeverine.