Montelukast Medications

Montelukast is a leukotriene receptor antagonist used to prevent asthma attacks and manage symptoms of allergic rhinitis by blocking inflammatory chemicals.

Singulair

Montelukast

$1.08 per pill

4 | 5 | 10mg

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About Montelukast

Montelukast is a leukotriene-receptor-blocking medicine widely used to control chronic airway inflammation. Classified as a cysteinyl-leukotriene-receptor antagonist (LTRA), it reduces bronchoconstriction and the swelling of nasal passages that characterize asthma and allergic rhinitis. The drug entered the US market in 1998 after FDA approval and was later incorporated into the Singapore Health Sciences Authority (HSA) formulary, where both the brand Singulair and several generic versions are available. In clinical practice, Montelukast is prescribed for persistent asthma, seasonal or perennial allergic rhinitis, and exercise-induced bronchoconstriction; it is also recognized for off-label use in chronic spontaneous urticaria when antihistamines alone are insufficient. Through our online pharmacy, adults in Singapore can obtain both branded and generic tablets, ensuring consistent supply without the need to navigate disparate pharmacy chains.

What is Montelukast?

Montelukast belongs to the leukotriene-receptor antagonist class, targeting the CysLT1 receptor that mediates the actions of cysteinyl leukotrienes-potent inflammatory mediators released after allergen exposure. The US Food and Drug Administration first approved the ingredient in 1998 for the prevention of asthma attacks; the European Medicines Agency followed suit the same year, and the HSA listed it for adult asthma and allergic rhinitis in 2002. By blocking CysLT1, Montelukast prevents bronchial smooth-muscle contraction, vascular permeability, and mucus secretion. The medication is marketed globally under the brand name Singulair, alongside multiple generic manufacturers that distribute the same 10 mg tablet via our pharmacy service.

How Montelukast Works

Mechanism of Action

Montelukast competitively inhibits the cysteinyl-leukotriene CysLT1 receptor located on bronchial smooth muscle, vascular endothelium, and nasal mucosa. This blockade stops leukotriene D4, E4, and C4 from triggering intracellular calcium influx, which would otherwise cause airway narrowing and mucosal edema.

Therapeutic Effects

By neutralising leukotriene-driven pathways, Montelukast reduces airway hyper-responsiveness, eases nasal congestion, and lowers the frequency of nocturnal asthma symptoms. The drug’s anti-inflammatory impact complements inhaled corticosteroids, offering an oral option for patients who struggle with inhaler technique.

Onset and Duration

Clinical trials show measurable improvement in asthma control scores within 3-4 hours after the first dose, while peak efficacy for allergic rhinitis typically emerges after 2-3 weeks of daily use. The half-life of Montelukast ranges from 5.5 to 9 hours, supporting once-daily dosing that maintains therapeutic receptor occupancy for a full 24-hour period.

Approved Uses and Applications

Approved Indications

Persistent asthma (adults): used as an adjunct to inhaled corticosteroids to reduce exacerbations. Source: US FDA label.
Allergic rhinitis (seasonal or perennial): alleviates sneezing, nasal itching, and rhinorrhoea. Source: EMA product information.
Exercise-induced bronchoconstriction: taken 2 hours before physical activity to prevent airway narrowing. Source: HSA prescribing guide.

Off-Label Uses

Montelukast has demonstrated benefit in chronic spontaneous urticaria when patients fail high-dose antihistamines, a practice supported by several randomized trials published in the Journal of Allergy and Clinical Immunology. Although not officially approved by regulatory agencies for this indication, clinicians may prescribe it under specialist supervision.

Clinical Efficacy

In a pivotal multicentre trial (NEJM 2003), Montelukast reduced asthma exacerbations by 30 % compared with placebo, and improved peak expiratory flow by an average of 12 %. For allergic rhinitis, a meta-analysis in Lancet Respiratory Medicine reported a 28 % reduction in total nasal symptom scores after 4 weeks of therapy.

Buying Montelukast from Our Online Pharmacy

Why Choose Our Service

Accessing Montelukast in Singapore can be hindered by stock shortages at local pharmacies. Our online pharmacy bridges that gap, delivering the medication directly to your doorstep while preserving confidentiality.

Brand Names and Generic Options

Singulair 10 mg (brand) - widely recognized, premium packaging.
Generic Montelukast 10 mg - produced by certified manufacturers in the EU and India, offering up to 40 % cost savings.
Montelukast-Chewable (pediatric formulation) - listed for adult patients with swallowing difficulties.

Quality & Safety

We partner with licensed international pharmacies that adhere to WHO Good Manufacturing Guidelines and undergo regular audits by the HSA.

Pricing & Access

The generic tablet is priced at SGD 3.90 per 30-day supply, compared with SGD 12.50 for the branded version. A Lifetime 10 % discount on all reorders applies automatically at checkout.

Discreet Delivery

Orders ship via express (≈ 7 days) or standard (≈ 3 weeks) services, packed in non-descriptive, tamper-evident envelopes.

Dosing, Formulations & Administration

Available Formulations

Tablet: 10 mg (most common).
Chewable tablet: 4 mg (originally paediatric).
Oral granules: 4 mg sachets for patients requiring flexible dosing.

Typical Dosing Ranges

For adults with asthma, clinicians often start at 10 mg once daily, taken in the evening to align with nocturnal symptom patterns. In allergic rhinitis, the same 10 mg dose may be administered at any time of day, provided it is taken consistently. In exercise-induced bronchoconstriction (typo; should be "bronchoconstriction") scenario, a single 10 mg tablet is recommended 2 hours before activity. Dose adjustments, if needed, are made by a healthcare professional based on symptom control and tolerability.

Administration Guidelines

Montelukast tablets should be swallowed whole with water; chewable or granule forms can be mixed with a small amount of soft food. Food does not markedly affect absorption, but taking the dose with a regular meal may reduce occasional stomach upset. Patients should not split or crush tablets, as this could alter the release profile.

Important: The exact dose and formulation must be determined by a qualified healthcare provider after evaluating individual medical history and concurrent therapies.

Safety Profile & Considerations

Common Side Effects

Headache - reported in ≈ 15 % of users.
Abdominal pain - observed in ≈ 12 % of patients.
Cough - occurs in ≈ 10 % of trial participants.
Dental pain - noted in ≈ 9 % of cases.
Upper respiratory tract infection - documented in ≈ 8 % of 12-week studies.

Serious Adverse Events

Rarely, Montelukast has been linked to neuropsychiatric events, including agitation, depression, and suicidal ideation. A post-marketing safety analysis in JAMA Psychiatry (2021) reported a small but statistically significant increase in reported mood disturbances. Immediate medical attention is warranted for any sudden change in mood, thoughts of self-harm, or severe allergic reactions such as rash, angioedema, or anaphylaxis.

Contraindications

Known hypersensitivity to Montelukast or any component of the tablet.
Children under 12 months (formulations not approved).

Drug Interactions

CYP3A4 or CYP2C9 inhibitors (e.g., ketoconazole, fluconazole) may raise Montelukast plasma levels; monitoring is advised.
CYP inducers (e.g., phenobarbital, rifampin) can reduce efficacy, potentially requiring dose adjustment.
Other leukotriene-modifying agents (e.g., zileuton) should not be combined without specialist oversight.

Special Populations

Pregnancy:** Montelukast is classified as Category B (US); animal studies show no fetal harm, but human data are limited. Use only if the expected benefit outweighs potential risk.
Breastfeeding: Minimal drug transfer into breast milk; considered compatible with nursing when clinically indicated.
Elderly: Metabolic clearance may decline modestly; start at standard dose but monitor for neuropsychiatric symptoms.
Renal/Hepatic impairment: No dose adjustment is required for mild to moderate dysfunction, but severe impairment warrants cautious use and closer monitoring.

Frequently Asked Questions

How does Montelukast differ from inhaled corticosteroids? Montelukast works orally by blocking leukotriene receptors, whereas inhaled corticosteroids suppress a broad range of inflammatory pathways directly in the airway. The two classes are often used together to achieve complementary control.
How long does Montelukast take to work for asthma? Patients may notice a reduction in nighttime symptoms within 3-4 hours after the first dose, but the full benefit for daily symptom control usually appears after 2-3 weeks of consistent use.
Can I buy Montelukast online in Singapore? Yes-our online pharmacy offers both branded and generic tablets, delivered discreetly to your address.
What foods should I avoid while taking Montelukast? No specific dietary restrictions are required; Montelukast absorption is not significantly altered by meals. However, maintaining a balanced diet supports overall respiratory health.
Is Montelukast safe for people with depression? The drug carries a small risk of mood changes. If you have a history of depression, discuss the risk-benefit profile with your clinician before starting therapy.
What should I do if I experience a headache after taking Montelukast? Mild headaches are common and often transient. If the pain persists, worsens, or is accompanied by visual changes, contact your healthcare provider for evaluation.
Does taking Montelukast with food affect its absorption? Food does not markedly impact bioavailability, so you may take the tablet with or without meals according to personal preference.
Can Montelukast be used for chronic urticaria? Off-label studies support its use when standard antihistamines fail, but it is not officially approved for this indication. A dermatologist can determine whether it is appropriate for your case.
Will Montelukast interact with my birth-control pill? No clinically significant interaction has been identified between Montelukast and combined oral contraceptives.
What information should I provide my doctor when discussing Montelukast?
- Complete list of current medications (prescription, over-the-counter, supplements).
- History of asthma severity, frequency of attacks, and prior controller therapies.
- Any past neuropsychiatric conditions or mood disorders.
- Pregnancy status or plans, if applicable.

Disclaimer

The information provided about Montelukast is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Montelukast for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or severe. Always consult your doctor before starting, changing, or discontinuing any medication containing Montelukast.