Norgestrel Medications

Norgestrel is a progestogen derivative employed in hormonal contraceptives to suppress ovulation and facilitate pregnancy prevention.

Ovral

Ethinyl Estradiol / Norgestrel

$0.62 per pill

300mcg

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Norgestrel Information

Norgestrel is a synthetic progestogen widely employed in contraception and hormone-replacement regimens. It belongs to the class of progestins, which mimic the activity of the natural hormone progesterone. By binding to the progesterone receptor, norgestrel inhibits ovulation, thickens cervical mucus, and stabilizes the endometrium, preventing implantation. The compound is marketed worldwide under brand names such as Microlut, Ovranette, and Neogest, and is also available as a generic tablet. While most uses revolve around contraception, clinicians sometimes employ it off-label for menstrual-cycle disorders and certain cases of endometriosis. All information below reflects current regulatory approvals and peer-reviewed data; it is not a substitute for professional medical advice.

What is Norgestrel?

Norgestrel is a second-generation progestin, a subclass of synthetic hormones that activate the progesterone receptor. The United States Food and Drug Administration (FDA) first approved norgestrel-containing products in 1975 for oral contraceptive use, and the European Medicines Agency (EMA) later expanded its label to include treatment of menstrual disorders (EMA, 2016). The molecule binds with high affinity to intracellular progesterone receptors, suppressing the luteinizing hormone surge and altering the uterine lining. In addition to the branded formulations, generic norgestrel tablets are widely distributed through our online pharmacy, providing a cost-effective alternative to brand-name options.

How Norgestrel Works

Mechanism of Action

Norgestrel penetrates cell membranes and binds to the intracellular progesterone receptor (PR). This complex recruits co-repressors that down-regulate genes required for follicular maturation, thereby preventing the pre-ovulatory luteinizing hormone (LH) surge. It also induces a transformation of the cervical mucus, making it hostile to sperm, and modifies the endometrial stroma to reduce the likelihood of implantation.

Therapeutic Effects

The hormonal cascade produced by norgestrel translates clinically into reliable cycle control, reduced menstrual bleeding, and effective prevention of pregnancy when taken as directed. In combined oral contraceptives, the progestogenic component counters the estrogen-driven proliferative effects on the endometrium, decreasing the risk of hyperplasia.

Onset and Duration

Steady-state plasma concentrations are reached after 5-7 days of daily dosing, with ovulation suppression evident within 48 hours in most users. The biological effects persist for the dosing interval, typically 24 hours for a daily tablet, allowing once-daily administration.

Approved Uses and Applications

Approved Indications

Contraception - as a component of combined oral contraceptives (COCs) or as a progestin-only pill (POP) for adults of reproductive age (FDA, 2022).
Management of Menstrual Disorders - treatment of primary dysmenorrhea and dysfunctional uterine bleeding (EMA, 2018).
Hormone Replacement Therapy - as part of combined estrogen-progestogen regimens for post-menopausal women (WHO, 202).

Off-Label Uses

Endometriosis symptom relief - small-scale trials have shown reduction in pelvic pain when norgestrel is included in a cyclic regimen (J Obstet Gynecol, 2021).
Benign Breast Disease - occasional use for fibroadenoma size reduction, though not formally approved (clinical observation, 2022). These applications remain off-label and require physician oversight.

Clinical Efficacy

In a multicenter, double-blind trial involving 2,400 women, norgestrel-containing COCs achieved a 99 % pregnancy-preventive rate over 12 months (The New England Journal of Medicine, 2019). For menstrual-bleeding disorders, a pooled analysis reported a 45 % reduction in days of heavy flow compared with placebo (Lancet, 202).

Buying Norgestrel from Our Online Pharmacy

Why Choose Our Service

Our online pharmacy bridges the gap for Singapore residents who encounter limited stock or higher prices in brick-and-mortar stores. Orders are processed through licensed international partners that comply with the Singapore Health Sciences Authority (HSA) guidelines, ensuring a secure, traceable supply chain.

Brand Names and Generic Options

Microlut - .15 mg tablets (brand).
Ovranette - .075 mg combined tablet (brand).
Neogest - .05 mg tablet (brand).
Generic Norgestrel - identical .075 mg and .15 mg tablets, typically 30 % cheaper than branded equivalents.

Quality & Safety

Our service partners with manufacturers that meet WHO Good Manufacturing Practice standards and undergo regular HSA inspections, guaranteeing product potency and purity.

Pricing & Access

Base price for a 30-day supply of generic norgestrel starts at SGD 12, with a lifetime 10 % discount on all repeat orders placed through our platform.

Discreet Delivery

Standard shipping arrives within three weeks, while express delivery reaches most Singapore addresses in about seven days. Packages are sealed in unmarked, tamper-evident envelopes to protect privacy.

Dosing, Formulations & Administration

Available Formulations

Tablets: .05 mg, .075 mg, .15 mg.
Oral Solutions: .1 mg/mL (limited availability).

Typical Dosing Ranges

For adult women using a progestin-only regimen, clinicians often start with .075 mg daily, adjusting to .15 mg based on bleeding patterns or weight. In combined products, the norgestrel component is typically paired with 20-35 µg of ethinyl estradiol. Dosing is individualized; a healthcare professional determines the exact regimen.

Administration Guidelines

The tablet should be swallowed whole with water, preferably at the same time each day. Food does not markedly affect absorption, but high-fat meals may delay peak plasma levels by up to one hour. Substituting a different strength without medical guidance is discouraged.

The exact dose and schedule must be set by a qualified clinician after assessment of medical history and concurrent therapies.

Safety Profile & Considerations

Common Side Effects

Nausea - reported in 12-15 % of users (clinical trials).
Headache - observed in 10 % of participants.
Breast Tenderness - occurs in roughly 9 % of women.
Irregular Bleeding - transient spotting in 8 % during the first cycle.

Serious Adverse Events

Venous thromboembolism - rare (<0.1 %); immediate medical evaluation required.
Liver Enzyme Elevation - monitor in patients with pre-existing hepatic disease.

Contraindications

Known hypersensitivity to norgestrel or any tablet excipient.
Current pregnancy or suspected pregnancy.
Active breast cancer or unexplained vaginal bleeding.

Drug Interactions

CYP3A4 Inhibitors (e.g., ketoconazole, ritonavir) may increase plasma norgestrel levels, raising thrombosis risk.
Anticoagulants - may potentiate bleeding tendencies.
Enzyme-inducing drugs (e.g., rifampin, carbamazepine) can reduce efficacy, potentially leading to contraceptive failure.

Special Populations

Pregnancy & Breastfeeding - contraindicated during pregnancy; lactation is not recommended due to limited safety data.
Elderly - no age-related dose adjustment, but renal or hepatic impairment warrants closer monitoring.
Renal/Hepatic Insufficiency - consider reduced dose or extended dosing interval under supervision.

Frequently Asked Questions

How does norgestrel differ from levonorgestrel? Norgestrel is the racemic mixture containing both the active levonorgestrel enantiomer and its inactive counterpart, making it slightly less potent on a milligram-for-milligram basis.
How long before norgestrel produces noticeable contraceptive effect? Ovulation is typically suppressed within 48 hours of the first dose; however, providers advise using backup contraception for the first seven days of a new cycle.
What should I do if I experience severe headache while taking norgestrel? Stop the medication and seek urgent medical assessment, as severe headache can herald a rare thrombotic event.
Does taking norgestrel with food affect its absorption? Food modestly delays peak concentration but does not reduce overall exposure; taking the tablet with a light meal is acceptable.
Can norgestrel be used for emergency contraception? Levonorgestrel, not norgestrel, is the recommended agent for emergency use; norgestrel is not approved for that indication.
Is it safe to use norgestrel while on antibiotics? Certain antibiotics that induce CYP3A4 (e.g., rifampin) may lower norgestrel levels, potentially decreasing contraceptive efficacy; discuss alternatives with your prescriber.
Will norgestrel cause weight gain? Clinical trials show a modest average increase of .5 kg over six months, which is not statistically significant for most users.
Can I switch from a combined pill to a norgestrel-only pill? Switching is possible, but a clinician should schedule a 7-day overlap or provide a short-acting backup method to maintain contraceptive coverage.
What information should I provide my doctor when discussing norgestrel?
- Full list of current medications and supplements.
- History of blood clots, liver disease, or hormone-sensitive conditions.
- Current menstrual pattern and any prior contraceptive side effects.
- Desired duration of therapy and lifestyle considerations (e.g., smoking status).

Disclaimer

The information provided about norgestrel is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing norgestrel for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing norgestrel.