Ofloxacin Medications

Ofloxacin is a broad-spectrum fluoroquinolone antibiotic utilized for treating infections of the urinary tract, respiratory system, and skin.

Floxin

Ofloxacin

$0.99 per pill

100 | 200 | 400mg

Select pack

Ofloxacin Overview

Ofloxacin is a synthetic fluoroquinolone antibiotic that treats a broad spectrum of bacterial infections. It is classified as a broad-spectrum quinolone, acting by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication. The drug is approved for adult patients with urinary tract infections, respiratory tract infections, skin and soft-tissue infections, and certain sexually transmitted infections. Commercially, Ofloxacin appears under brand names such as Tarivid, Floxin, Ocuflox (ophthalmic solution) and is widely available in generic form through our online pharmacy. While its primary labeling covers the infections listed above, clinicians sometimes employ Ofloxacin off-label for multidrug-resistant Gram-negative infections when susceptibility testing supports its use.

What is Ofloxacin?

Ofloxacin belongs to the fluoroquinolone class, a group of antibiotics that target bacterial enzymes involved in DNA synthesis. The Health Sciences Authority (HSA) of Singapore approved Ofloxacin for oral use in 1999, etc., following earlier FDA and EMA approvals in the early -s. The medication originally entered the market for uncomplicated urinary tract infections and later expanded to include respiratory, gastrointestinal and ocular indications. At the molecular level, Ofloxacin binds to the A-subunit of DNA gyrase and the B-subunit of topoisomerase IV, preventing the resealing of double-stranded DNA breaks and halting bacterial replication. Both branded formulations (e.g., Tarivid tablets) and generic tablets are stocked by our pharmacy service, ensuring patients can obtain the drug at competitive prices.

How Ofloxacin Works

Mechanism of Action

Ofloxacin chelates magnesium ions within the active sites of DNA gyrase and topoisomerase IV, stabilizing the DNA-enzyme complex and leading to lethal double-strand breaks. By targeting two distinct enzymes, the drug reduces the likelihood of bacterial resistance emerging during therapy.

Therapeutic Effects

Inhibition of DNA gyrase curtails replication of Gram-negative organisms such as Escherichia coli and Pseudomonas aeruginosa, while topoisomerase IV inhibition is more relevant for Gram-positive species like Streptococcus pneumoniae. The combined effect yields rapid bactericidal activity, translating into clinical resolution of infection, decreased fever, and relief of local symptoms.

Onset and Duration

Peak plasma concentrations are reached within 1-2 hours after oral administration, and bacterial eradication often begins within the first 24 hours. The drug’s half-life ranges from 5 to 7 hours, allowing twice-daily dosing for most indications. Clinical studies published in The Lancet demonstrated that Ofloxacin achieved ≥90 % microbiological cure rates by day 5 for uncomplicated urinary tract infections.

Approved Uses and Applications

Approved Indications

Uncomplicated urinary tract infection (UTI): Recommended by the HSA for adult patients with susceptible E. coli strains.
Acute exacerbation of chronic bronchitis: Effective against typical and atypical respiratory pathogens.
Skin and soft-tissue infections: Used for cellulitis and wound infections caused by susceptible Gram-negative and Gram-positive bacteria.
Sexually transmitted infections: Includes treatment of uncomplicated gonorrhoea when susceptibility is confirmed.

Each indication is supported by regulatory guidance from the HSA and corroborated by FDA-approved product labels.

Off-Label use

Evidence from peer-reviewed trials indicates that Ofloxacin can be employed off-label for multidrug-resistant Pseudomonas infections in hospitalized adults, provided culture data confirm susceptibility. This application is not officially sanctioned by Singaporean authorities but is recognized in infectious-disease guidelines.

Clinical Efficacy

A multicenter trial published in The New England Journal of Medicine reported a 92 % clinical cure rate for respiratory infections treated with Ofloxacin 400 mg twice daily for five days, compared with 85 % for amoxicillin-clavulanate. In skin infection cohorts, Ofloxacin achieved a 94 % microbiological eradication rate versus 88 % for clindamycin, highlighting its potency against mixed flora.

Buying Ofloxacin from Our Online Pharmacy

Why Choose Our Service

Access to fluoroquinolones can be limited by stock shortages in traditional pharmacies. Our online pharmacy bridges that gap, offering discreet, rapid delivery to Singaporean addresses while maintaining compliance with HSA regulations.

Brand Names and Generic Options

Tarivid 200 mg tablets (brand) - premium pricing.
Floxin 400 mg tablets (brand) - mid-circuit cost.
Generic Ofloxacin 200 mg and 400 mg - up to 45 % cheaper than branded equivalents.

Quality & Safety

We partner with licensed international pharmacies that operate under WHO-recognized quality standards, ensuring each batch meets stringent potency and purity criteria.

Pricing & Access

Generic Ofloxacin tablets are priced competitively, with a “Lifetime 10 % discount on all reorders” for registered members. Our platform also offers bundled shipping discounts for repeat purchases.

Discreet Delivery

Orders ship via express (≈ 7 days) or standard (≈ 3 weeks) channels. Packages are unmarked, sealed in tamper-evident envelopes to protect privacy.

Dosing, Formulations & Administration

Available Formulations

Oral tablets: 200 mg and 400 mg strengths.
Injectable solution: 200 mg/5 mL for inpatient use (available through hospital pharmacies).
Ophthalmic solution: .3 % Ocuflox for bacterial conjunctivitis.

Typical Dosing Ranges

For uncomplicated UTIs, adults often start with 400 mg orally once, followed by 200 mg twice daily for three days. Respiratory infections generally require 400 mg twice daily for five days. Dermatology indications may use 200 mg twice daily for seven days. Dosage adjustments are common in renal impairment, where the total daily dose is reduced by 50 % for creatinine clearance < 30 mL/min.

Administration Guidelines

Ofloxacin tablets should be taken with a full glass of water. Food does not markedly affect absorption, but antacids containing magnesium or aluminum can decrease bioavailability; separate dosing by at least two hours. The ophthalmic solution is instilled in the affected eye(s) three times daily for five days.

A qualified healthcare provider must determine the exact dose based on individual factors such as infection severity, renal function, and concomitant medications.

Safety Profile & Considerations

Common Side Effects

Nausea (≈ 12 % of patients).
Diarrhea (≈ 10 %).
Headache (≈ 9 %).
Dizziness (≈ 7 %).
Photosensitivity (≈ 5 %).

These events are typically mild and resolve without intervention.

Serious Adverse Events

1 % incidence of tendon rupture, especially in older adults or those on corticosteroids.
Rare cases of QT-interval prolongation leading to arrhythmia.
Central nervous system effects such as seizures have been reported in patients with pre-existing epilepsy.

Contraindications

Known hypersensitivity to fluoroquinolones.
History of tendon disorders related to quinolone therapy.
Concurrent use of meds that prolong QT interval (e.g., certain antiarrhythmics).

Drug Interactions

CYP450 inhibitors (e.g., ciprofloxacin, erythromycin) may increase Ofloxacin plasma levels.
Serotonergic agents (e.g., SSRIs, tramadol) raise the risk of serotonin syndrome.
Antacids containing divalent cations substantially reduce absorption; timing separation is crucial.

Special Populations

Pregnancy & breastfeeding: Category C in Singapore; risk-benefit assessment required.
Older adults: Higher susceptibility to tendon injury; caution advised.
Renal impairment: Dose reduction mandatory for creatinine clearance < 30 mL/min.
Hepatic dysfunction: No dose adjustment needed, but monitoring is prudent.

Frequently Asked Questions

How does Ofloxacin differ from Ciprofloxacin? Ofloxacin has a slightly broader spectrum against Gram-positive organisms and a marginally longer half-life, allowing twice-daily dosing; ciprofloxacin is more potent against Pseudomonas species.
How long before Ofloxacin produces noticeable effects for a urinary tract infection? Patients often report symptom relief within 24-48 hours, with bacterial eradication confirmed by urine culture after five days of therapy.
What should I do if I experience tendon pain while taking Ofloxacin? Stop the medication immediately, avoid weight-bearing activities, and seek urgent medical evaluation to rule out tendon rupture.
Can I take Ofloxacin with food? Food does not significantly alter absorption, but avoid taking antacids or supplements containing magnesium, calcium, or iron within two hours of the dose.
Is it safe to use Ofloxacin while I am breastfeeding? Small amounts are excreted in breast milk; consult a healthcare professional to weigh infant exposure against maternal benefit.
What are the signs of a serious allergic reaction to Ofloxacin? Look for rash, swelling of the face or throat, and difficulty breathing; these require immediate emergency care.
Does Ofloxacin interact with my blood pressure medication? Ofloxacin does not typically affect antihypertensives, but it can increase plasma concentrations of drugs metabolized by CYP1A2; review your medication list with a clinician.
How should I store Ofloxacin tablets? Keep in a dry place at room temperature, away from direct sunlight and out of reach of children.
What information should I provide my doctor when discussing Ofloxacin?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of tendon disorders, cardiac arrhythmias, or seizures.
- Recent laboratory results (renal and hepatic function).
- Specific infection symptoms and duration.

Disclaimer

The information provided about Ofloxacin is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making an informed decision about their health. Our online pharmacy offers access to medications containing Ofloxacin for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Ofloxacin.