Perindopril Medications

Perindopril is an ACE inhibitor that widens blood vessels to reduce blood pressure. It is used for hypertension and heart failure management.

Aceon

Perindopril

$1.61 per pill

2 | 4 | 8mg

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About Perindopril

Perindopril is an angiotensin-converting enzyme (ACE) inhibitor that lowers blood pressure, reduces cardiac workload, and protects the kidneys in people with diabetes. First approved by the European Medicines Agency in 1995 for hypertension, it was later expanded to treat heart failure, post-myocardial infarction remodeling, and diabetic nephropathy. The drug blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and decreasing aldosterone-driven sodium retention. It is marketed worldwide under names such as Coversyl and Aceon, and generic versions are widely available, including through our online pharmacy. While its primary uses are well-established, clinicians sometimes employ Perindopril off-label for stroke prevention in high-risk patients, reflecting its broader vascular benefits.

What is Perindopril?

Perindopril belongs to the ACE-inhibitor class, a cornerstone of modern antihypertensive therapy. The Health Sciences Authority of Singapore approved the drug in 1998 for the treatment of essential hypertension, and later extensions covered chronic heart failure and post-myocardial infarction management. By binding to the active site of angiotensin-converting enzyme, Perindopril prevents the formation of angiotensin II, leading to reduced systemic vascular resistance and lower arterial pressure. The interruption of the renin-angiotensin-aldosterone system also diminishes ventricular remodeling after a heart attack, improving long-term outcomes. In Singapore, the medication is sold both as the branded product Coversyl and as an unbranded generic, each supplied via licensed distributors and accessible through our pharmacy service.

How Perindopril Works

Mechanism of Action

Perindopril is a prodrug that is hydrolyzed in the liver to its active form, perindoprilat. Perindoprilat competitively inhibits ACE, which normally converts angiotensin I to the vaso-constrictor angiotensin II. The resulting decrease in angiotensin II lowers vasoconstriction, reduces aldosterone secretion, and promotes natriuresis.

Therapeutic Effects

By blunting the renin-angiotensin cascade, Perindopril produces three clinically important effects: (1) arterial vasodilation that lowers systolic and diastolic blood pressure, (2) reduced preload and afterload that eases the heart’s pumping effort, and (3) attenuation of renal intraglomerular pressure, slowing the progression of diabetic kidney disease.

Onset and Duration

Peak plasma concentrations of perindoprilat appear within 3-4 hours after oral intake, and blood pressure reductions can be observed as early as one week of consistent dosing. The antihypertensive effect persists for 24 hours, supporting once-daily administration. Clinical studies have shown sustained blood pressure control for up to 12 months when adherence is maintained, and long-term cardiovascular benefit continues beyond five years in heart-failure cohorts.

Approved Uses and Applications

Approved Indications

Essential hypertension: First-line therapy recommended by Singapore’s Clinical Practice Guidelines.
Chronic heart failure: Improves left-ventricular ejection fraction and reduces hospitalization risk.
Post-myocardial infarction: Limits adverse ventricular remodeling and lowers mortality.
Diabetic nephropathy: Slows decline in glomerular filtration rate when combined with optimal glycemic control.

Regulatory authorities-including the HSA, the FDA, and the EMA-recognize these indications based on large-scale randomized trials such as the ADVANCE and PROGRESS studies.

Off-Label Uses

Some cardiologists prescribe Perindopril for secondary stroke prevention in patients with a history of ischemic events, although the Singapore Health Authority has not formally approved this indication.

Clinical Efficacy

The PROGRESS trial, published in The Lancet, demonstrated a 20 % relative risk reduction in recurrent stroke for patients receiving an ACE inhibitor plus a thiazide diuretic. In the EUROPA trial, Perindopril reduced the composite endpoint of cardiovascular death, myocardial infarction, or stroke by 20 % compared with placebo in patients with stable coronary artery disease.

Buying Perindopril from Our Online Pharmacy

Why Choose Our Service

Access to high-quality antihypertensive medication can be challenging when local pharmacies run low on stock. Via our online service, you can order Perindopril discreetly and have it delivered to any Singapore address, bypassing typical supply bottlenecks.

Brand Names and Generic Options

Coversyl (100 mg tablets): Widely recognized brand, priced competitively.
Aceon (5 mg capsules): Useful for low-dose titration.
Generic Perindopril: Identical active ingredient, typically 30 % cheaper than branded equivalents.

Quality & Safety

We partner with licensed international pharmacies that adhere to WHO Good Manufacturing Practices, ensuring each package meets stringent potency and purity standards.

Pricing & Access

Generic Perindopril tablets start at SGD .15 per tablet, while branded options range from SGD .45 to SGD .70. All customers receive a Lifetime 10 % discount on all reorders, making long-term therapy affordable.

Discreet Delivery

Express shipping arrives in approximately seven days, and Standard shipping takes up to three weeks. Every order is sealed in unmarked, tamper-evident packaging to protect your privacy.

Dosing, Formulations & Administration

Available Formulations

Perindopril is supplied as oral tablets (2.5 mg, 5 mg, 10 mg, 20 mg) and capsules (5 mg, 10 mg). The common strengths enable flexible titration based on clinical response.

Typical Dosing Ranges

For adults with hypertension, treatment often begins at 5 mg once daily; clinicians may increase to 10 mg after two weeks if the target blood pressure is not reached. Heart-failure protocols usually start at 2.5 mg and titrate to 10 mg, while diabetic nephropathy regimens typically use 4-8 mg daily. Dose adjustments must reflect renal function, age, and concomitant medications.

Administration Guidelines

Perindopril can be taken with or without food; however, swallowing the tablet whole with a glass of water minimizes gastrointestinal irritation. Patients should avoid high-potassium diets if they are also on potassium-sparing diuretics, as the combination may raise serum potassium levels.

Important: A qualified healthcare provider must determine the exact dose for each individual, taking into account comorbidities and concurrent therapies.

Safety Profile & Considerations

Common Side Effects

Cough (dry, non-productive): Reported in ~12 % of users; often leads to discontinuation.
Dizziness or light-headedness: Occurs in about 8 % when standing quickly, related to blood pressure drop.
Headache: Seen in roughly 7 % of patients during the first weeks of therapy.
Hyperkalemia: Mild elevations in serum potassium observed in 5 % of patients, especially when combined with ACE inhibitors or potassium supplements.

Serious Adverse Events

Angio-edema: Rare (<0.2 %) but potentially life-threatening swelling of the face, lips, or airway; requires immediate medical attention.
Acute renal failure: May develop in patients with bilateral renal artery stenosis or severe dehydration; monitor creatinine after initiation.

Contraindications

History of hereditary or idiopathic angio-edema.
Concurrent use of another ACE inhibitor or aliskiren in diabetic patients.
Pregnancy (especially the second and third trimesters) due to fetal toxicity.

Drug Interactions

CYP450 inhibitors (e.g., ritonavir): Can increase plasma levels of perindoprilat.
Potassium-sparing diuretics (e.g., spironolactone): Heighten risk of hyperkalemia.
Non-steroidal anti-inflammatory drugs (NSAIDs): May blunt antihypertensive effect and worsen renal function.

Special Populations

Pregnancy & breastfeeding: Contraindicated; switch to a safer alternative.
Elderly: Initiate at the lowest dose (2.5 mg) and titrate slowly due to increased sensitivity to blood pressure changes.
Renal impairment: Patients with creatinine clearance <30 mL/min require dose reduction and close monitoring.
Hepatic disease: No dose adjustment is usually needed, but liver dysfunction can delay conversion of the prodrug.

Frequently Asked Questions

How does Perindopril differ from ramipril? Both are ACE inhibitors, but Perindopril has a longer half-life and may provide more stable 24-hour blood pressure control, whereas ramipril reaches peak effect slightly earlier.
What is the typical time frame for Perindopril to lower blood pressure? Noticeable reductions often appear within one week, with full effect achieved after 2-4 weeks of consistent dosing.
Can I take Perindopril with a high-potassium diet? While occasional potassium-rich foods are safe, combining Perindopril with potassium supplements or salt substitutes can raise serum potassium to unsafe levels; discuss dietary plans with your clinician.
What should I do if I develop a persistent dry cough while on Perindopril? Report the symptom to your healthcare provider; they may switch you to an angiotensin II receptor blocker (ARB) that does not trigger cough.
Is it safe to use over-the-counter NSAIDs while on Perindopril? Short-term NSAID use is generally tolerated, but chronic use can diminish blood-pressure control and stress kidney function; monitor renal markers if NSAIDs are needed regularly.
How long can I safely continue Perindopril therapy? Long-term use is common; studies show cardiovascular benefit persisting for years when the drug is well-tolerated and renal function remains stable.
Does taking Perindopril with food affect its absorption? Food does not significantly impact bioavailability, but taking the tablet with a full glass of water reduces the chance of esophageal irritation.
What are the signs of angio-edema that require urgent care? Swelling of the lips, tongue, throat, or difficulty breathing should prompt immediate emergency evaluation.
Can Perindopril be used in patients with mild liver disease? Yes; the hepatic conversion of the prodrug is generally unaffected by mild hepatic impairment, but severe liver disease warrants caution.
What information should I provide my doctor when discussing Perindopril?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of kidney or liver disease, and any previous episodes of angio-edema.
- Current blood-pressure readings and target goals.
- Lifestyle factors such as diet, alcohol intake, and smoking status.

Disclaimer

The information provided about Perindopril is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Perindopril for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Perindopril.