Podophyllum Resin Medications

Podophyllum Resin is an antimitotic compound derived from plants that stops cell growth in warts. It is used topically for treating genital warts.

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Podophyllum Resin

$22.10 per bottle

10ml

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Podophyllum Resin Details

Podophyllum Resin is a plant-derived antimitotic agent extracted from the rhizomes of Podophyllum species. It is most widely recognized for its role in eradicating external genital warts (condyloma acuminata) and, in some settings, for treating peri-anal and peri-genital intra-epithelial lesions. The resin contains podophyllotoxin, the pharmacologically active lignan that interferes with cell division. In Singapore, the Health Sciences Authority (HSA) has approved topical formulations containing podophyllotoxin for adult patients, and the ingredient is available under several brand names as well as generic options. Though its primary indication is wart removal, clinicians sometimes employ the resin off-label for selected viral skin conditions when alternative therapies are unsuitable. Understanding how Podophyllum Resin works, its dosing options, and its safety profile helps patients make informed choices, especially when seeking to purchase Podophyllum Resin online through reputable channels.

What is Podophyllum Resin?

Podophyllum Resin belongs to the antimitotic class of topical chemotherapeutic agents. The Health Sciences Authority of Singapore accepted its first registration in 2004 for the treatment of external genital warts, and the United States Food and Drug Administration (FDA) granted similar approval for podophyllotoxin-based products in 1999. The resin’s core molecular driver, podophyllotoxin, binds to the tubulin protein, halting microtubule assembly and arresting cells in the metaphase stage of mitosis. By preventing the replication of virally infected epithelial cells, the resin clears wart tissue without systemic absorption when applied correctly. Commercially, the ingredient appears in branded creams such as Condylox® and Podofilox®, as well as in unlabeled generic tubes that can be obtained from our online pharmacy. All formulations deliver the same active compound in a concentration ranging from .5% to .8% for topical use.

How Podophyllum Resin Works

Mechanism of Action

Podophyllum Resin’s podophyllotoxin component attaches to the β-tubulin subunit of microtubules, disrupting polymerization. This inhibition prevents the formation of the spindle fibers required for chromosome segregation, leading to mitotic arrest and eventual apoptosis of the targeted epithelial cells. The effect is localized because the resin’s large molecular size limits deep tissue penetration.

Therapeutic Effects

The mitotic block translates into rapid necrosis of wart tissue, allowing the immune system to clear residual viral particles. Clinically, patients observe a flattening of lesions within days, followed by complete resolution over two to four weeks of intermittent application.

Onset and Duration

Clinical trials published in The New England Journal of Medicine documented a median onset of visible wart flattening within 5 days after the first application. Full clearance typically requires 2-4 weeks of twice-daily treatment, alternating days to minimize local irritation. The resin’s effect persists as long as the viral epithelium remains suppressed; re-infection may occur if exposure continues.

Approved Uses and Applications

Approved Indications

External genital warts (condyloma acuminata) in adults ≥ 18 years, as stipulated by the HSA and FDA.
Peri-anal warts when other topical agents are contraindicated, per EMA labeling.

These indications are supported by randomized controlled trials showing > 80 % complete clearance after four weeks of treatment.

Off-Label Uses

Podophyllum Resin has been employed in limited case series for:

Molluscum contagiosum resistant to imiquimod.
Plane warts on the face or hands when patients cannot tolerate retinoids.

These applications are not officially approved by regulatory agencies; clinicians use them only after weighing risk-benefit ratios.

Clinical Efficacy

A multicenter study in Lancet Infectious Diseases reported a 77 % cure rate for genital warts after a 4-week regimen, with a median time to complete response of 21 days. Comparative trials indicate that Podophyllum Resin achieves similar clearance rates to imiquimod but with a shorter treatment timeline, making it a preferred option for patients seeking rapid results.

Buying Podophyllum Resin from Our Online Pharmacy

Why Choose Our Service

Access to podophyllotoxin-based products can be limited in Singapore due to stock fluctuations at traditional pharmacies. Our online pharmacy bridges that gap, offering discreet, same-day order processing and secure delivery directly to your doorstep.

Brand Names and Generic Options

Condylox® - .5 % cream, FDA-approved.
Podofilox® - .5 % solution, EMA-registered.
Ersal® - .8 % gel, available in select Asian markets.

Generic tubes containing the same podophyllotoxin concentration are typically 30-40 % less expensive, letting you buy Podophyllum Resin online without compromising quality.

Quality & Safety

We partner with licensed international pharmacies that adhere to WHO Good Manufacturing Practices, ensuring each product meets stringent potency and sterility standards.

Pricing & Access

Our platform lists competitive prices, with an additional Lifetime 10 % discount on all reorders for returning customers. Shipping options include Express (≈ 7 days) and Standard (≈ 3 weeks), both packaged in tamper-evident, discreet boxes.

Discreet Delivery

Every order arrives in unmarked packaging, protecting your privacy while complying with Singapore’s customs regulations.

Dosing, Formulations & Administration

Available Formulations

Podophyllum Resin is marketed as a cream, solution, or gel, most commonly at .5 % or .8 % concentrations. Each container usually holds 2 g of product, sufficient for a typical 4-week course.

Typical Dosing Ranges

For adult patients with genital warts, clinicians often start with twice-daily application (morning and evening) for three consecutive days, followed by a four-day rest period. This cycle may repeat up to four times, depending on lesion response. Dosage adjustments are made by the prescribing clinician based on tolerability and wart size.

Administration Guidelines

Apply a thin layer directly to the wart, avoiding surrounding healthy skin.
Wash hands before and after use.
Do not cover the treated area with bandages unless directed, as occlusion can increase systemic absorption.

A healthcare provider must determine the exact regimen for each individual, taking into account medical history, lesion characteristics, and concurrent therapies.

Safety Profile & Considerations

Common Side Effects

Local irritation (redness, burning) - reported in > 15 % of users.
Erosion or ulceration of the treated skin - observed in 5-8 % of cases.
Hyperpigmentation after healing - noted in up to 10 % of patients.

These effects are usually mild to moderate and resolve after discontinuation.

Serious Adverse Events

Rarely, systemic absorption can cause bone marrow suppression, presenting as leukopenia or thrombocytopenia. Immediate medical evaluation is required if patients develop unexplained fever, bruising, or persistent fatigue.

Contraindications

Pregnancy or breastfeeding - teratogenic risk confirmed by animal studies.
Known hypersensitivity to podophyllotoxin or any component of the formulation.
Extensive facial or mucosal lesions, where systemic exposure is more likely.

Drug Interactions

Podophyllum Resin is a substrate of CYP3A4; co-administration with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) may increase systemic levels if absorption becomes significant. Concurrent use with other topical antimitotics or harsh keratolytics should be avoided to prevent additive irritation.

Special Populations

Pregnancy: Avoid use; counsel patients on reliable contraception during treatment.
Breastfeeding: Not recommended; podophyllotoxin can be excreted in milk.
Elderly: Skin barrier may be thinner; start with the lowest effective concentration.
Renal/Hepatic Impairment: No dosage adjustment is needed for topical use, but monitor for signs of systemic toxicity in severe organ dysfunction.

Frequently Asked Questions

What is the difference between Podophyllum Resin and imiquimod? Podophyllum Resin directly halts cell division by targeting tubulin, leading to rapid wart necrosis, while imiquimod stimulates local immune responses. The resin typically works faster but may cause more local irritation.
How long before I notice improvement after applying Podophyllum Resin? Most patients see wart flattening within 5 days; full clearance often requires 2-4 weeks of intermittent treatment.
Can I use Podophyllum Resin on facial warts? Use on the face is off-label and should be reserved for cases where other therapies have failed, under close supervision to minimize scarring.
What should I do if I develop severe burning or ulceration? Discontinue the product immediately and seek medical attention; these signs may indicate excessive absorption or allergic reaction.
Is it safe to apply Podophyllum Resin while pregnant? No. The resin is contraindicated in pregnancy because podophyllotoxin has demonstrated teratogenic effects in animal studies.
Are there foods I should avoid while using Podophyllum Resin? No specific dietary restrictions exist, but avoid grapefruit juice if you are taking systemic CYP3A4 inhibitors concurrently.
Can I combine Podophyllum Resin with other wart treatments? Concurrent use with other topical chemotherapeutic agents can increase irritation; discuss any combination therapy with your clinician first.
How does the resin’s concentration affect treatment duration? Higher concentrations (.8 %) may achieve faster clearance but carry a greater risk of irritation; clinicians balance efficacy and tolerability when selecting strength.
What information should I provide my doctor when discussing Podophyllum Resin?
- Complete list of current medications, including over-the-counter drugs and supplements.
- Any history of skin reactions or allergies.
- Pregnancy status or plans for conception.
- Description of wart location, size, and duration.

Disclaimer

The information provided about Podophyllum Resin is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Podophyllum Resin for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult doctor before starting, changing, or discontinuing any medication containing Podophyllum Resin.