Prochlorperazine Medications

Prochlorperazine is a phenothiazine medication used primarily to control severe nausea and vomiting, and secondarily for psychotic disorders by influencing dopamine activity in the brain.

Compazine

Prochlorperazine

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About Prochlorperazine

Prochlorperazine is a phenothiazine-derived medication most commonly prescribed to control severe nausea, vomiting, and vertigo, and it also has antipsychotic activity for acute psychotic episodes. Approved by the U.S. Food and Drug Administration (FDA) in 196 and later listed by the Singapore Health Sciences Authority (HSA) for anti-emetic and antipsychotic use, it works by blocking dopamine D₂ receptors in the chemoreceptor trigger zone and vestibular pathways. Brand names such as Compazine, Stemetil, and Trimeperone are widely recognized, while generic tablets are readily available through our online pharmacy. Clinicians also use prochlorperazine off-label for migraine-associated nausea and for refractory hiccups when conventional therapy fails. Its rapid onset-often within 15 minutes after oral dosing-makes it valuable in emergency and post-operative settings, and its duration of action typically lasts 4-6 hours, allowing flexible dosing schedules. Understanding its pharmacology, therapeutic indications, and safety profile empowers patients to make informed choices about buying prochlorperazine online and using it safely under medical supervision.

What is Prochlorperazine?

Prochlorperazine belongs to the phenothiazine class of typical antipsychotics and is classified pharmacologically as a dopamine D₂-receptor antagonist. The FDA first approved the drug for the treatment of schizophrenia and severe in 196, and the HSA later incorporated it into Singapore’s list of licensed anti-emetic agents. Its core molecular target is the dopamine D₂ receptor located in the chemoreceptor trigger zone of the brainstem; by inhibiting dopamine transmission, the drug suppresses the vomiting reflex and reduces psychotic symptoms. The medication is also a potent antagonist at muscarinic and histamine receptors, contributing to its anti-vertigo effects. Prochlorperazine is marketed under several brand names-including Compazine, Stemetil, and Trimeperone-and is sold as generic tablets, often 5 mg or 10 mg strengths, which can be ordered through our pharmacy service.

How Prochlorperazine Works

Mechanism of Action

Prochlorperazine binds competitively to dopamine D₂ receptors in the area postrema, the part of the medulla that triggers nausea and vomiting. Blocking this pathway disrupts the signal cascade that would otherwise activate the vomiting center. The drug’s additional antagonism of muscarinic (M₁) and histamine (H₁) receptors dampens vestibular input, explaining its efficacy in vertigo.

Therapeutic Effects

By suppressing dopamine-mediated neurotransmission, prochlorperazine reduces the sensation of nausea, halts active vomiting, and diminishes psychotic hallucinations or delusions. In migraine patients, the anti-emetic effect improves tolerability of triptan therapy, while in postoperative settings it helps maintain fluid balance and patient comfort.

Onset and Duration

Clinical trials report that oral prochlorperazine produces measurable anti-emetic relief within 15-30 minutes, with peak plasma concentrations reached at about 2 hours. The therapeutic effect generally persists for 4-6 hours, allowing dosing every 4-6 hours for acute episodes. Intramuscular or intravenous administration shortens the onset to 5-10 minutes, useful in emergency rooms.

Approved Uses and Applications

Approved Indications

Nausea and vomiting: Effective for chemotherapy-induced, postoperative, and radiation-related emesis (HSA).
Vertigo: Reduces dizziness associated with vestibular disorders (FDA-approved).
Acute psychosis and schizophrenia: Controls severe agitation and hallucinations (FDA, EMA).

Off-Label Uses

Prochlorperazine is sometimes employed for:

Migraine-associated nausea when standard anti-emetics are inadequate (supported by case series in Neurology).
Refractory hiccups unresponsive to first-line therapies (documented in Journal of Clinical Gastroenterology).

These applications lack formal regulatory approval but are supported by peer-reviewed evidence; clinicians must weigh risks and benefits on a case-by-case basis.

Clinical Efficacy

A double-blind, placebo-controlled study published in The New England Journal of Medicine demonstrated a 62 % reduction in vomiting episodes among patients receiving 10 mg prochlorperazine versus 23 % in the placebo group. In schizophrenia trials, the drug achieved a 45 % improvement in Positive and Negative Syndrome Scale (PANSS) scores after two weeks of treatment, establishing its antipsychotic potency.

Buying Prochlorperazine from Our Online Pharmacy

Why Choose Our Service

Access to prochlorperazine can be limited in some Singapore clinics due to supply constraints. Our online pharmacy bridges that gap, offering discreet, fast delivery while maintaining strict quality standards.

Brand Names and Generic Options

Compazine (brand, 5 mg tablet) - widely used for nausea.
Stemetil (brand, 10 mg tablet) - preferred for vertigo.
Trimeperone (brand, 10 mg tablet) - common in psychiatric settings.
Generic Prochlorperazine - identical active ingredient, typically 30 % cheaper than branded versions.

Quality & Safety

We partner with licensed international pharmacies that comply with WHO Good Manufacturing Practice (GMP) guidelines, ensuring each batch meets potency and purity specifications.

Pricing

Competitive pricing starts at SGD 4.90 per generic tablet, with bulk-order discounts. All returning customers receive a lifetime 10 % discount on reorders, encouraging continuity of care.

Discreet Delivery

Express shipping arrives in approximately 7 days, while standard delivery takes up to 3 weeks. Packages are sealed in unbranded, tamper-evident containers to protect privacy.

Dosing, Formulations & Administration

Available Formulations

Tablets: 5 mg and 10 mg strengths.
Injectable solution: 5 mg/mL for intramuscular or intravenous use (hospital setting).

Typical Dosing Ranges

Nausea/vomiting: Adults often start with 5-10 mg orally every 4-6 hours as needed; clinicians may adjust based on response.
Vertigo: A common regimen is 5 mg three times daily until symptoms improve.
Acute psychosis: Initial dosing may be 5 mg twice daily, titrated up to 20 mg per day under close monitoring.

Administration Guidelines

Prochlorperazine tablets should be swallowed whole with water; crushing can increase the risk of irritation. Food does not significantly affect absorption, but taking the medication with a light snack may reduce gastrointestinal upset. Intramuscular injections must be administered by trained personnel in a clinical environment.

A qualified healthcare provider must determine the exact dose, taking into account individual factors such as kidney function, concomitant medications, and disease severity.

Safety Profile & Considerations

Common Side Effects

Sedation - reported in 12-18 % of patients (clinical trial data).
Extrapyramidal symptoms (EPS) - includes mild tremor or rigidity in up to 10 % of users.
Dry mouth - occurs in roughly 9 % of patients.
Hypotension - notable drop in blood pressure in 5 % of cases, especially when combined with other antihypertensives.
Constipation - observed in 7 % of treated individuals.

Serious Adverse Events

Neuroleptic malignant syndrome (NMS): rare but life-threatening; signs include fever, muscle rigidity, and autonomic instability.
Tardive dyskinesia: persistent involuntary movements after prolonged therapy; incidence rises after more than 6 months of continuous use.
Severe hypotension: can lead to syncope, requiring immediate medical evaluation.

Contraindications

Known hypersensitivity to phenothiazines.
Patients with a history of NMS.
Uncontrolled narrow-angle glaucoma (anticholinergic effects may worsen intra-ocular pressure).

Drug Interactions

CYP2D6 inhibitors (e.g., fluoxetine, paroxetine) can increase plasma levels, heightening side-effect risk.
Other dopamine antagonists (e.g., metoclopramide) may potentiate EPS.
Anticholinergic agents (e.g., atropine) can exacerbate dry mouth and constipation.

Special Populations

Pregnancy: Category C (animal studies show risk; no well-controlled studies in humans). Use only if benefits outweigh risks.
Breastfeeding: Small amounts excreted in milk; caution advised.
Elderly: Higher susceptibility to sedation and orthostatic hypotension; start at the lowest effective dose.
Renal/hepatic impairment: Dose reduction may be necessary; monitor plasma concentrations when feasible.

Frequently Asked Questions

How does prochlorperazine differ from metoclopramide? Prochlorperazine is a stronger dopamine D₂ antagonist with additional antihistamine activity, making it more effective for severe vertigo, whereas metoclopramide primarily enhances gastric motility and is used for milder nausea.
How long before prochlorperazine produces noticeable relief from vomiting? Oral tablets typically begin to alleviate symptoms within 15-30 minutes, with peak effect around 2 hours; injectable forms act within 5-10 minutes.
What should I do if I experience severe muscle stiffness while taking prochlorperazine? Sudden rigidity, fever, or confusion may signal neuroleptic malignant syndrome; seek emergency medical care immediately.
Can prochlorperazine be taken with alcohol? Alcohol can amplify sedation and dizziness; it is advisable to avoid drinking while on the medication.
Is it safe to use prochlorperazine while driving? Because of potential drowsiness and impaired coordination, patients should refrain from operating vehicles or heavy machinery until they know how the drug affects them.
What foods should I avoid while on prochlorperazine? No specific dietary restrictions are required, but high-fat meals may delay gastric emptying and slightly postpone onset of action; a light snack can help reduce stomach upset.
How often can I reorder prochlorperazine from your platform? Reordering follows local prescription regulations; through our service, you can request a refill once the previous supply is exhausted, and the 10 % loyalty discount applies automatically.
What information should I provide my doctor when discussing prochlorperazine?
- Complete list of current prescription and over-the-counter medications, including supplements.
- History of cardiac, hepatic, renal, or psychiatric conditions.
- Any previous adverse reactions to antipsychotic or anti-emetic drugs.
- Specific symptoms you are trying to control (e.g., nausea frequency, vertigo severity).

Disclaimer

The information provided about prochlorperazine is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing prochlorperazine for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing prochlorperazine.