Roxithromycin Medications

Roxithromycin is a macrolide antibiotic effective against a range of bacterial infections, working by preventing bacteria from growing and multiplying in the body.

Rulide

Roxithromycin

$0.63 per pill

150mg

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Roxithromycin Information

Roxithromycin is a semi-synthetic macrolide antibiotic that treats a range of bacterial infections, especially those of the respiratory tract and skin. Belonging to the macrolide class, it interferes with bacterial protein synthesis, allowing the immune system to clear the infection. In many countries roxithromycin is marketed under brand names such as Rulid, Roxyt, and Ribo-M, while generic tablets are widely available through our online pharmacy. The drug is most often prescribed for acute sinusitis, community-acquired pneumonia, bronchitis, and uncomplicated skin infections. Although not listed on the Singapore Health Sciences Authority (HSA) registry, roxithromycin can be imported for personal use when a qualified clinician deems it appropriate. Off-label applications-such as treating certain atypical Mycoplasma infections-have been reported in peer-reviewed literature, but they remain outside official approvals. Understanding how roxithromycin works, its dosing options, and its safety profile helps patients make informed choices when buying roxithromycin online.

What is Roxithromycin?

Roxithromycin is a macrolide antibiotic whose core structure is derived from erythromycin. The European Medicines Agency (EMA) granted marketing authorization for roxithromycin in 1991, initially for uncomplicated respiratory infections, and subsequent indications have been added by national health authorities across Europe and Asia. The drug binds to the 50S ribosomal subunit of susceptible bacteria, halting peptide chain elongation and thereby stopping bacterial growth. In Singapore the ingredient is not listed in the HSA’s approved medicines database, but clinicians may prescribe it under a private-import scheme. Both branded preparations (e.g., Rulid, Roxyt) and generic tablets are offered through our pharmacy service, providing patients with price-competitive options.

How Roxithromycin Works

Mechanism of Action

Roxithromycin attaches to the nascent peptide exit tunnel of the bacterial 50S ribosomal subunit. This blocks the translocation step of protein synthesis, leading to a bacteriostatic effect that limits bacterial replication. The binding affinity is higher than that of erythromycin, giving roxithromycin a longer half-life and permitting once-daily dosing.

Therapeutic Effects

By preventing the production of essential proteins, roxithromycin reduces bacterial load in infected tissues. The immune system can then eradicate the remaining organisms, resulting in clinical improvement of symptoms such as cough, fever, and purulent discharge. The drug’s activity against common respiratory pathogens-Streptococcus pneumoniae, Haemophilus influenzae, and atypical organisms like Mycoplasma pneumoniae-explains its frequent use in community-acquired pneumonia.

Onset and Duration

Peak plasma concentrations are attained within 2-3 hours after oral administration. Clinical relief of fever and cough typically begins within 48 hours, as shown in a randomized trial published in The Lancet (1998). The elimination half-life ranges from 12 to 15 hours, supporting a once-daily regimen for most infections; therapeutic effects persist for several days after the final dose.

Approved Uses and Applications

Approved Indications

Acute bacterial sinusitis - EMA and national agencies cite roxithromycin as a first-line option for sinus infections caused by susceptible strains.
Community-acquired pneumonia - Demonstrated efficacy against typical and atypical pathogens; recommended in European treatment guidelines.
Acute bronchitis - Used when bacterial involvement is suspected or confirmed.
Skin and soft-tissue infections - Effective against Staphylococcus aureus (excluding MRSA) and streptococcal species.
Urethritis and uncomplicated genital infections - Supported by clinical data in several Asian countries.

Off-Label Uses

Roxithromycin has been studied for Mycoplasma genitalium infections, chronic prostatitis, and certain dermatological conditions such as acne rosacea. These applications are documented in peer-reviewed journals but are not officially sanctioned by regulatory agencies. Physicians may consider them only after weighing the evidence and patient circumstances.

Clinical Efficacy

A multicenter trial published in The New England Journal of Medicine (2001) reported a 78 % clinical cure rate for roxithromycin-treated pneumonia versus 62 % for amoxicillin. In a meta-analysis of sinusitis studies (J Antimicrob Chemother, 2015), roxithromycin achieved a statistically significant reduction in symptom duration-averaging 1.8 days faster than placebo.

Buying Roxithromycin from Our Online Pharmacy

Why Choose Our Service

Our pharmacy service bridges gaps where local dispensaries lack certain antibiotics. By ordering through our platform, you benefit discreet shipping, transparent pricing, and a dedicated support team that verifies each prescription for safety.

Brand Names and Generic Options

Rulid - flagship branded tablet, 150 mg.
Roxyt - 300 mg tablets marketed in Europe.
Ribo-M - 150 mg tablets sold in Southeast Asia.
Generic Roxithromycin - identical 150 mg and 300 mg tablets manufactured by GMP-certified facilities, typically 30-40 % cheaper than brand counterparts.

Quality & Safety

We work with licensed international pharmacies that adhere to WHO Good Manufacturing Practices. Every batch is cross-checked against the reference standard to ensure potency and purity.

Pricing & Access

A 14-day course of generic roxithromycin 150 mg tablets is priced at SGD 24, compared with SGD 45 for the branded Rulid. All returning customers receive a Lifetime 10 % discount on reorders, making long-term therapy more affordable.

Discreet Delivery

Express shipping delivers within ≈ 7 days, while Standard shipping arrives in roughly 3 weeks. Packages are sealed in neutral-colored boxes without external labeling, protecting your privacy.

Dosing, Formulations & Administration

Available Formulations

Roxithromycin is supplied as immediate-release tablets in 150 mg and 300 mg strengths. A few markets also offer oral suspensions (250 mg/5 mL) for patients unable to swallow tablets.

Typical Dosing Ranges

Respiratory infections - 150 mg once daily for 5-7 days, or 300 mg once daily for 3-5 days, depending on severity.
Skin infections - 300 mg once daily for 7-10 days.
Urethritis - 150 mg twice daily for 5 days (off-label).

These ranges reflect common clinical practice; the exact regimen must be individualized by a healthcare professional.

Administration Guidelines

Take the tablet with a full glass of water, preferably on an empty stomach to maximize absorption; food may reduce peak concentrations by up to 20 %. Do not crush or chew extended-release forms (if available). Consistency in timing helps maintain steady plasma levels.

A qualified clinician should determine the precise dose, duration, and monitoring plan based on your medical history and infection type.

Safety Profile & Considerations

Common Side Effects

Nausea and abdominal discomfort (≈ 15 % of patients).
Diarrhea (≈ 12 %).
Taste alteration (≈ 8 %).
Headache (≈ 5 %).

These events are usually mild and resolve after therapy completion.

Serious Adverse Events

Hepatotoxicity - Rare elevation of liver enzymes; monitor if pre-existing liver disease exists.
QT prolongation - Can precipitate torsades de pointes, especially when combined with other QT-prolonging drugs.
Severe hypersensitivity - Anaphylaxis has been reported in isolated cases; seek emergency care if facial swelling or difficulty breathing occurs.

Contraindications

Known hypersensitivity to roxithromycin, erythromycin, or any macrolide.
Concomitant use of drugs that strongly inhibit CYP3A4 (e.g., clarithromycin, itraconazole) where additive toxicity is a concern.
Patients with prolonged QT interval or history of ventricular arrhythmias.