Tadalafil Medications
Tadalafil is a PDE5 inhibitor medication used to treat erectile dysfunction by improving blood flow to the penis, and it also helps manage symptoms of benign prostatic hyperplasia.
Buy Tadalafil Medications
About Tadalafil Compound
Tadalafil belongs to the class of phosphodiesterase-5 (PDE5) inhibitors and is widely prescribed for erectile dysfunction, benign prostatic hyperplasia (BPH) and pulmonary arterial hypertension. By blocking the PDE5 enzyme, it sustains cyclic guanosine monophosphate (cGMP) levels, leading to smooth-muscle relaxation in target tissues. The drug appears on the market under brand names such as Cialis, Adcirca and Cialis Daily, while generic versions are also readily available. In addition to its approved uses, clinicians occasionally employ tadalafil off-label for conditions like Raynaud’s phenomenon or altitude-related hypoxia, though such practices lack formal regulatory endorsement. Its long half-life-often cited as “the weekend pill”-provides therapeutic effects that can persist for up to 36 hours after a single dose, distinguishing it from shorter-acting PDE5 inhibitors.
What is Tadalafil?
Tadalafil is a selective PDE5 inhibitor originally approved by the U.S. Food and Drug Administration in 2003 for the treatment of erectile dysfunction. The European Medicines Agency followed with a conditional approval the same year, and the World Health Organization added it to its Model List of Essential Medicines in 2015. In Singapore, the Health Sciences Authority (HSA) classifies tadalafil as a Schedule 4 prescription medicine, allowing it to be dispensed through licensed pharmacies.
The molecule binds competitively to the PDE5 catalytic site, preventing the breakdown of cGMP in the corpus cavernosum, lower urinary tract and pulmonary vasculature. Elevated cGMP triggers smooth-muscle relaxation, increased blood flow, and subsequent alleviation of symptoms. Tadalafil is marketed globally under several brand names, most prominently Cialis (Eli Lilly), Adcirca (Bayer) for pulmonary hypertension, and Cialis Daily for continuous BPH therapy. Generic tablets containing the same active ingredient are manufactured by numerous reputable firms and can be purchased via our online pharmacy.
How Tadalafil Works
Mechanism of Action
Tadalafil selectively inhibits the phosphodiesterase-5 enzyme, an isozyme that degrades cyclic guanosine monophosphate (cGMP). By preserving cGMP concentrations, the drug amplifies nitric-oxide-mediated signaling pathways, resulting in vasodilation of arterial and trabecular smooth muscle. This effect is most pronounced in the penile tissue, pulmonary arteries and the prostate’s urethral smooth muscle.
Therapeutic Effects
When cGMP accumulates, smooth-muscle cells relax, venous outflow is reduced, and arterial inflow increases. In erectile tissue, this produces an erection sufficient for sexual activity. In the prostate and bladder neck, relaxation eases urinary obstruction, improving flow rates and reducing nocturia. In the pulmonary circulation, vasodilation lowers pulmonary arterial pressure, benefitting patients with pulmonary arterial hypertension.
Onset and Duration
Clinical trials report that therapeutic plasma concentrations are reached within 30 minutes to 2 hours after oral administration. For erectile dysfunction, patients commonly notice an effect within 1 hour, and the benefit can last up to 36 hours. Daily dosing for BPH yields steady-state concentrations after approximately 5 days, maintaining symptom relief continuously. In pulmonary hypertension, the onset of hemodynamic improvement appears within 2 hours, with sustained effects throughout the dosing interval.
Approved Uses and Applications
Approved Indications
- Erectile Dysfunction (ED): Recommended as needed or daily low-dose therapy for adult males. The FDA, EMA and HSA all endorse this indication.
- Benign Prostatic Hyperplasia (BPH): Daily 5 mg dosing improves urinary flow and reduces symptom scores, per FDA and EMA labeling.
- Pulmonary Arterial Hypertension (PAH): Marketed as Revatio, the drug lowers mean pulmonary arterial pressure, approved by the FDA in 2009 and recognized by the HSA for PAH management.
Off-Label Uses
Physicians have reported using tadalafil for Raynaud’s phenomenon, altitude-related hypoxia and certain cases of muscular dystrophy, but these applications lack formal regulatory approval. Patients should discuss any off-label intent with a qualified clinician.
Clinical Efficacy
A pooled analysis published in The New England Journal of Medicine demonstrated that 78 % of men achieved successful intercourse with tadalafil 20 mg taken as needed, compared with 54 % on placebo. In a multicenter BPH trial reported in The Lancet, 71 % of participants experienced a ≥3-point improvement in the International Prostate Symptom Score after 12 weeks of daily 5 mg therapy. For PAH, Circulation reported a mean reduction of 10 mm Hg in pulmonary arterial pressure after 12 weeks of 40 mg daily dosing.
Buying Tadalafil from Our Online Pharmacy
Why Choose Our Service
Our pharmacy service eliminates geographic barriers, delivering high-quality tadalafil directly to Singaporean households. Discreet packaging, secure payment options and a transparent ordering process ensure a hassle-free experience.
Brand Names and Generic Options
Key branded products include Cialis (standard dose), Cialis Daily (2.5 mg and 5 mg), Adcirca (40 mg) and Cialis for BPH (5 mg). Generic tadalafil tablets, produced by FDA-registered manufacturers, match the active-ingredient profile of their branded counterparts at a fraction of the cost.
Quality & Safety
Through our online service, we partner with licensed international pharmacies that comply with WHO Good Manufacturing Practice (GMP) standards. Every batch undergoes third-party verification to guarantee potency and purity.
Pricing & Access
Competitive pricing on generic tadalafil often yields savings of 30-50 % compared with brand-name equivalents. Customers who enroll in the Lifetime 10 % discount program enjoy additional reductions on all future reorders, regardless of dosage strength.
Discreet Delivery
Express shipping arrives within approximately 7 days, while the standard option reaches most Singapore addresses in about 3 weeks. All parcels are enclosed in unmarked boxes, protecting privacy and minimizing the risk of unwanted exposure.
Dosing, Formulations & Administration
Available Formulations
Tadalafil is supplied as oral tablets in strengths of 2.5 mg, 5 mg, 10 mg, 20 mg and 40 mg. The 2.5 mg and 5 mg tablets are typically used for daily BPH therapy, whereas the 10 mg and 20 mg tablets serve on-demand erectile dysfunction treatment. The 40 mg dose is reserved for pulmonary arterial hypertension under medical supervision.
Typical Dosing Ranges
- Erectile Dysfunction: A single 10 mg or 20 mg tablet taken at least 30 minutes before sexual activity; the dose may be reduced to 5 mg based on tolerability.
- Benign Prostatic Hyperplasia: One 5 mg tablet daily, taken at the same time each day.
- Pulmonary Arterial Hypertension: One 40 mg tablet daily, usually administered in the morning.
These examples reflect standard clinical practice; the exact regimen must be individualized by a healthcare professional.
Administration Guidelines
Tadalafil can be taken with or without food; a high-fat meal may delay onset by up to 2 hours. Alcohol enhances vasodilatory effects and may increase the risk of dizziness, so moderate consumption is advisable. Swallow tablets whole with a glass of water; crushing or chewing can alter absorption.
A qualified clinician should determine the final dose, taking into account kidney or liver function, concomitant medications and overall health status.
Safety Profile & Considerations
Common Side Effects
- Headache: Reported in about 11 % of users.
- Indigestion (Dyspepsia): Occurs in roughly 7 % of patients.
- Back Pain and Myalgia: Typically appear 12-24 hours after dosing, affecting 4-5 % of individuals.
- Flushing: Noted in 6 % of trial participants.
- Nasal Congestion: Seen in 4 % of cases.
These events are usually mild to moderate and resolve without intervention.
Serious Adverse Events
Rare but potentially life-threatening reactions include sudden vision loss (non-arteritic anterior ischemic optic neuropathy), priapism lasting longer than 4 hours, and severe cardiovascular events such as myocardial infarction or stroke. Immediate medical evaluation is warranted if any of these occur.
Contraindications
- Concurrent nitrates (e.g., nitroglycerin, isosorbide dinitrate) due to risk of profound hypotension.
- Severe uncontrolled hypertension (systolic >180 mm Hg or diastolic >110 mm Hg).
- Recent (<30 days) stroke or intracardiac septal defect.
- Hereditary retinal diseases (e.g., retinitis pigmentosa).
Drug Interactions
- CYP3A4 inhibitors (ketoconazole, ritonavir, clarithromycin) can raise tadalafil plasma levels, necessitating dose reduction.
- Alpha-blockers (tamsulosin, doxazosin) may cause additive blood-pressure lowering effects.
- Other PDE5 inhibitors must never be combined.
- Antihypertensives may require monitoring for additive hypotensive effects.
Special Populations
- Pregnancy & Breastfeeding: Tadalafil is not indicated; limited data exist, so avoidance is recommended.
- Elderly: Age-related renal or hepatic decline may require lower starting doses.
- Renal Impairment: For creatinine clearance <30 mL/min, a maximum of 5 mg daily is advised.
- Hepatic Impairment: Moderate liver disease (Child-Pugh B) warrants dose reduction; severe disease (Child-Pugh C) is a contraindication.
Frequently Asked Questions
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How does Tadalafil differ from Sildenafil? Tadalafil has a longer half-life (≈36 hours) compared with Sildenafil’s 4-hour profile, allowing more spontaneous timing of sexual activity. Sildenafil reaches peak concentration faster, typically within 60 minutes.
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How long does it take for Tadalafil to work for erectile dysfunction? Most men notice an erection-facilitating effect within 30 minutes to 2 hours after ingestion. Food can modestly delay onset, but the drug remains effective for up to 36 hours.
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Can I take Tadalafil daily for BPH and still use it as needed for ED? Yes; the daily 5 mg regimen maintains steady plasma levels for BPH while also supporting spontaneous erectile function. Adjustments should be made only under medical guidance.
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What should I do if I experience a painful erection lasting more than 4 hours? Seek emergency medical care immediately; prolonged erections (priapism) can cause permanent tissue damage if untreated.
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Are there specific foods or drinks I should avoid while on Tadalafil? Grapefruit juice can inhibit CYP3A4, potentially increasing drug exposure. Excessive alcohol may heighten dizziness and lower blood pressure, so moderation is advisable.
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Is Tadalafil safe for men with cardiovascular disease? Individuals with stable heart disease may use Tadalafil, but those taking nitrates or with recent cardiac events must avoid it. A cardiologist should evaluate suitability.
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Does kidney function affect Tadalafil dosing? Reduced renal clearance can raise drug levels; patients with severe impairment often start at 5 mg daily, with close monitoring.
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Can Tadalafil be used to treat pulmonary arterial hypertension in Singapore? Yes, the 40 mg daily formulation (Revatio) is approved for PAH, but it requires prescription and specialist oversight.
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What is the recommended storage condition for Tadalafil tablets? Store at room temperature, between 20 °C and 25 °C (68 °F-77 °F), protected from moisture and direct sunlight.
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What information should I provide my doctor when discussing Tadalafil?
- Complete list of current medications, including over-the-counter drugs and supplements.
- History of cardiovascular disease, hypertension, or eye disorders.
- Any use of nitrates or alpha-blockers.
- Specific symptoms you aim to treat (ED, BPH, PAH) and their severity.
Disclaimer
The information provided about Tadalafil is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Tadalafil for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Tadalafil.
