Vardenafil Medications
Vardenafil is a PDE5 inhibitor that enhances nitric oxide effects to improve erectile function. It is indicated for the treatment of erectile dysfunction in adult males.
Buy Vardenafil Medications
About Vardenafil
Vardenafil is a phosphodiesterase-type-5 (PDE5) inhibitor that restores erectile function by enhancing the nitric-oxide-cGMP pathway in the penile tissue. Approved worldwide for the treatment of erectile dysfunction, it is available under brand names such as Levitra and Staxyn, as well as in generic form. The drug works only after sexual stimulation, providing a rapid onset of action-typically within 30 to 60 minutes-and a therapeutic window lasting up to five hours. Vardenafil’s efficacy, tolerability, and once-daily dosing options have made it a mainstay for men seeking reliable improvement in sexual performancelabel, clinicians sometimes consider it for pulmonary arterial hypertension, although this indication is not officially sanctioned. When you buy vardenafil online through our online pharmacy, you can access both branded and generic versions at competitive prices while maintaining privacy and convenience.
What is Vardenafil?
Vardenafil belongs to the PDE5 inhibitor class, a group of drugs that prevent the breakdown of cyclic guanosine monophosphate (cGMP) in smooth-muscle cells. The Health Sciences Authority (HSA) of Singapore approved vardenafil in 2005 for erectile dysfunction, following earlier approvals by the U.S. Food and Drug Administration (2003) and the European Medicines Agency. Its core molecular target is the PDE5 enzyme, which is abundant in the corpus cavernosum of the penis. By blocking this enzyme, vardenafil amplifies the natural vasodilatory signal that follows sexual arousal, leading to increased blood flow and erection. The medication is marketed worldwide as Levitra, Staxyn, and in generic tablets of 5 mg, 10 mg, and 20 mg. All formulations can be ordered from our pharmacy service, which sources products that meet HSA-mandated quality standards.
How Vardenafil Works
Mechanism of Action
Vardenafil selectively inhibits phosphodiesterase-5, the enzyme responsible for degrading cGMP within penile smooth muscle. When sexual stimulation releases nitric oxide, guanylate cyclase converts GTP to cGMP. Elevated cGMP relaxes smooth muscle, allowing arterial inflow to engorge the corpora cavernosa. By preserving cGMP, vardenafil prolongs this relaxation phase, facilitating an erection that can be maintained for the duration of sexual activity.
Therapeutic Effects
The preserved cGMP translates directly into measurable clinical outcomes: increased penile rigidity, longer erection duration, and improved ability to achieve satisfactory intercourse. In randomized trials, men receiving vardenafil reported erections sufficient for intercourse in approximately 70 % of attempts, compared with around 30 % in placebo groups.
Onset and Duration
Peak plasma concentrations occur within 1 hour after oral dosing, with therapeutic effects detectable as early as 30 minutes. The drug’s half-life is roughly 4 hours, supporting a functional window of 4-5 hours. Food can modestly delay absorption but does not markedly reduce overall exposure.
Approved Uses and Applications
Approved Indications
- Erectile Dysfunction (ED): For adult men who experience difficulty achieving or maintaining an erection sufficient for intercourse. (Regulated by HSA, FDA, EMA)
- Male Sexual Dysfunction secondary to diabetes: Vardenafil is indicated for ED in patients with type 2 diabetes when standard therapy is insufficient.
Off-Label Uses
Although not officially sanctioned, some urologists explore vardenafil for:
- Pulmonary arterial hypertension (PAH): Small studies suggest modest hemodynamic improvement, but the indication lacks regulatory approval.
- Benign prostatic hyperplasia-related lower urinary tract symptoms: Limited evidence indicates potential symptom relief when combined with α-blockers.
Clinical Efficacy
The pivotal NEJM study (2005) enrolled 835 men with ED; vardenafil 10 mg achieved a 69 % ≥ “successful intercourse” rate versus 26 % with placebo (p < .001). A later Lancet meta-analysis (2018) confirmed a mean increase of 4.2 points on the International Index of Erectile Function-5 (IIEF-5) scale, confirming robust efficacy across age groups.
Buying Vardenafil from Our Online Pharmacy
Why Choose Our Service
Access to vardenafil can be hampered by limited stock in local pharmacies or higher brand-name pricing. Our platform bridges that gap, offering discreet, direct-to-door delivery and transparent pricing that often undercuts brick-and-mortar outlets.
Brand Names and Generic Options
- Levitra (10 mg) - the flagship brand, priced competitively in our catalogue.
- Staxyn (orodispersible tablets, 10 mg) - convenient for men who prefer not to swallow pills.
- Generic Vardenafil (5 mg, 10 mg, 20 mg) - bio-equivalent, up to 30 % cheaper than branded versions.
Quality & Safety
We partner with licensed international pharmacies that comply with WHO Good Manufacturing Practices and are inspected by the Singapore HSA. Every batch is verified for potency and purity before shipment.
Pricing & Access
Generic vardenafil tablets start at SGD .85 per 10 mg unit, while branded Levitra typically costs SGD 2.40 per tablet. A “Lifetime 10 % discount on all reorders” is applied automatically at checkout, encouraging long-term adherence without financial strain.
Discreet Delivery
Orders are packaged in unmarked, tamper-evident envelopes. Express shipping reaches most Singapore districts within 7 days; standard delivery arrives in 3 weeks, both with full tracking.
Dosing, Formulations & Administration
Available Formulations
- Tablets: 5 mg, 10 mg, 20 mg (film-coated).
- Oro-dispersible tablets (Staxyn): 10 mg.
Typical Dosing Ranges
For most adults with ED, clinicians start with 10 mg taken 30 minutes before anticipated sexual activity. Depending on efficacy and tolerability, the dose may be increased to 20 mg or decreased to 5 mg. In diabetic patients, the same range applies but clinicians may monitor glycemic control more closely.
Administration Guidelines
- Take the tablet whole with a glass of water; do not crush or chew.
- Food, especially a high-fat meal, can delay absorption by up to 30 minutes-plan accordingly.
- Avoid concurrent use of nitrates (e.g., nitroglycerin) because of the risk of severe hypotension.
A qualified healthcare professional must determine the exact dose based on individual health status, concomitant medications, and treatment goals.
Safety Profile & Considerations
Common Side Effects
- Headache - reported in ≈ 15 % of users.
- Flushing - occurs in ≈ 10 % of patients.
- Dyspepsia - seen in ≈ 9 % of cases.
- Nasal congestion - reported by ≈ 8 % of users.
- Back pain - noted in ≈ 4 % of participants.
Serious Adverse Events
- Priapism (prolonged erection > 4 h): requires immediate medical attention; incidence < .1 %.
- Severe hypotension: especially when combined with nitrates or potent α-blockers.
- Cardiovascular events (myocardial infarction, stroke): rare but reported in patients with pre-existing heart disease.
Contraindications
- Concurrent nitrate therapy (e.g., isosorbide dinitrate).
- Uncontrolled hypertension (> 170/100 mmHg).
- Recent (< 30 days) myocardial infarction or stroke.
- Known hypersensitivity to vardenafil or any excipients.
Drug Interactions
- CYP3A4 inhibitors (ketoconazole, erythromycin, HIV protease inhibitors) can raise vardenafil plasma levels, increasing side-effect risk.
- CYP3A4 inducers (rifampin, carbamazepine) may reduce efficacy.
- Alpha-blockers (tamsulosin, doxazosin) may cause additive blood-pressure lowering.
Special Populations
- Pregnancy & Breastfeeding: Not indicated; animal data show no adverse fetal effects, but human studies are lacking.
- Elderly: Pharmacokinetics are modestly altered; start at the low end of the dosing range.
- Renal impairment: For creatinine clearance < 30 mL/min, a 5 mg dose is recommended.
- Hepatic impairment: Mild to moderate disease does not require dose adjustment; severe disease warrants careful monitoring.
Frequently Asked Questions
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How does Vardenafil differ from Sildenafil? Vardenafil has a slightly faster onset (≈ 30 minutes vs ≈ 45 minutes for sildenafil) and a marginally longer half-life, allowing a flexible window of sexual activity. Both share the same PDE5-inhibition mechanism but differ in side-effect profiles and food interactions.
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How long before Vardenafil produces noticeable effects for erectile dysfunction? Most men report a functional erection within 30-60 minutes after dosing. Peak efficacy usually occurs around 1 hour, making it suitable for spontaneous or planned intimacy.
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What should I do if I experience a headache after taking Vardenafil? Mild headaches are common and often resolve without intervention. Staying hydrated and avoiding excessive alcohol may help. If the headache persists or worsens, contact a healthcare professional for guidance.
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Can Vardenafil be taken with alcohol? Moderate alcohol consumption does not significantly affect vardenafil’s efficacy, but excessive intake can impair sexual performance and increase the risk of hypotension. Limit alcohol to ≤ 2 standard drinks when planning sexual activity.
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Does taking Vardenafil with food affect its absorption? A high-fat meal can delay the drug’s absorption by ≈ 30 minutes, potentially postponing its onset. For the quickest effect, take the tablet on an empty stomach or after a light meal.
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Are there any long-term safety concerns with daily Vardenafil use? Daily low-dose regimens (e.g., 5 mg) have been studied for up to 12 months with no increase in serious adverse events compared with on-demand dosing. Ongoing monitoring of blood pressure and vision is still recommended.
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What are the signs of priapism that require emergency care? A persistent, painful erection lasting longer than 4 hours, unrelieved by ejaculation, is a medical emergency. Seek immediate attention to prevent permanent tissue damage.
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Can Vardenafil be used by men with diabetes? Yes. Clinical trials demonstrate comparable efficacy in diabetic and non-diabetic men, though response rates may be slightly lower in the diabetic subgroup. Dose adjustments are based on individual tolerance.
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Is there a generic version of Vardenafil available in Singapore? Generic vardenafil tablets (5 mg, 10 mg, 20 mg) are approved by the HSA and can be purchased via our online pharmacy, offering a cost-effective alternative to branded Levitra.
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What information should I provide my doctor when discussing Vardenafil?
- Current list of prescription and over-the-counter medications, including supplements.
- History of cardiovascular disease, blood pressure status, and any nitrate use.
- Presence of diabetes, liver or kidney impairment, and any prior episodes of priapism.
- Lifestyle factors such as alcohol consumption and smoking that may influence treatment.
Disclaimer
The information provided about Vardenafil is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Vardenafil for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Vardenafil.
