Buy Acyclovir cream 5%
Acyclovir cream 5%
Acyclovir cream 5% Properties
About Acyclovir cream 5%
Acyclovir cream 5 % is a topical antiviral preparation approved for the treatment of recurrent cold-sores (herpes labialis) and other superficial herpes simplex virus (HSV) skin infections. The active ingredient, acyclovir, belongs to the nucleoside analogue class and works by inhibiting viral DNA replication. In Singapore the product is available in 5 g and 10 g tubes and is commonly prescribed when lesions are in the early stages or when rapid symptom relief is desired. While the cream is primarily indicated for HSV-1 lesions on the lips and face, clinicians sometimes consider it for HSV-2 genital lesions or for varicella-zoster virus (shingles) in limited circumstances. Understanding the pharmacology, proper application, and realistic expectations can help patients achieve the best possible outcome while minimizing unwanted effects.
What is Acyclovir Cream 5 %?
Acyclovir cream 5 % is the generic formulation that contains the antiviral agent acyclovir at a concentration of five percent (w/w). It is marketed in the United Kingdom and many Asian markets under the brand name Zovirax by GlaxoSmithKline, but the same formulation is widely offered by a range of reputable manufacturers as a cost-effective alternative. In Singapore the product is classified as prescription-only medicine (POM) and can be dispensed by community pharmacies when a registered practitioner provides a valid prescription.
Acyclovir belongs to the nucleoside analogue therapeutic class. The cream is designed for local application to intact or ulcerated skin, delivering the active compound directly to the infected area while limiting systemic exposure. The topical route provides a rapid onset of action for superficial lesions, making it a valuable tool in the early management of HSV outbreaks.
How Acyclovir Cream 5 % Works
Acyclovir mimics the natural nucleoside guanosine. Once inside a cell infected with HSV, the viral thymidine kinase enzyme phosphorylates acyclovir to acyclovir monophosphate. Host cellular kinases then add two further phosphate groups, converting it into acyclovir triphosphate, the pharmacologically active form. This triphosphate competitively incorporates into viral DNA during replication, causing premature chain termination because acyclovir lacks the 3′-hydroxyl group needed for further elongation.
Because the drug is selectively activated by viral thymidine kinase, healthy cells experience minimal conversion to the active triphosphate, accounting for the relatively low toxicity of topical acyclovir. After application, measurable drug concentrations appear in the stratum corneum within minutes, with peak tissue levels reached in approximately one hour. The antiviral effect persists for several hours, allowing twice-daily dosing to maintain inhibitory concentrations throughout the typical 48-hour replication window of HSV lesions.
Systemic absorption from the cream is negligible; plasma levels are generally below the limit of quantification, even when the entire tube is applied. Consequently, drug-drug interactions are rare, and the medication can be used safely alongside most systemic agents, including oral contraceptives and antihypertensives.
Why Acyclovir Cream 5 % Is Used for Skin-Care and Antiviral Conditions
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Early-stage herpes labialis - Laboratory studies have shown that acyclovir reduces viral replication when applied within the prodromal tingling phase. Clinical trials demonstrate a reduction in lesion duration from an average of five days to roughly three days, and a lower likelihood of ulcer formation when treatment starts before vesicle appearance. This mechanistic alignment-blocking DNA synthesis before the virus spreads to neighboring keratinocytes-explains the observed clinical benefit.
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Recurrent HSV-2 genital lesions - Although oral acyclovir tablets are the standard, the cream can be useful for localized, mild genital eruptions where systemic exposure is undesirable. Small pilot studies suggest that topical therapy shortens healing time by about 20 % when combined with hygienic measures, likely because the drug reaches the ulcer base directly, suppressing viral replication at the source.
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Herpes-associated eczema herpeticum - In patients with atopic dermatitis who develop superimposed HSV infection, rapid viral control is essential to prevent widespread skin involvement. Acyclovir cream, when used alongside systemic antivirals, provides an added local antiviral shield, helping to curb the spread of viral particles across compromised skin barriers.
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Post-exposure prophylaxis after minor skin trauma - For individuals with a known history of frequent HSV outbreaks who sustain a superficial abrasion in an area prone to recurrences, applying the cream within six hours can interrupt the early replication cycle. The rationale is the same: pre-emptive inhibition of viral DNA synthesis before the virus establishes a robust infection.
These indications share a common thread: the drug acts where the virus first attempts to replicate. By delivering the active compound directly to the site of inoculation, acyclovir cream maximizes the probability of halting the infection before it expands.
Off-Label and Investigational Uses of Acyclovir Cream 5 %
Some clinicians have explored the topical agent for herpes zoster (shingles) crusted lesions, especially in immunocompromised patients where systemic therapy may be limited by renal function. Small case series indicate that applying the cream to the affected dermatome can reduce the duration of crust formation, though robust randomized data are lacking. Studies suggest that the topical route may complement oral antivirals, but off-label use only under qualified healthcare provider supervision is advised.
Another emerging application involves prevention of HSV transmission in serodiscordant couples. Limited laboratory work demonstrates that daily application to the genital area reduces detectable viral shedding, yet clinical trials remain underway. Patients interested in such experimental protocols should discuss them with a specialist, as the approach remains investigational.
Is Acyclovir Cream 5 % Right for You?
The cream is most appropriate for adults who experience recurrent oral herpes or who have a confirmed HSV lesion on accessible skin. Ideal candidates are those who can recognize prodromal symptoms and apply the medication promptly. Individuals with severe immunosuppression, extensive mucosal disease, or atypical lesions (e.g., deep necrotic ulcers) may require systemic therapy rather than a topical formulation.
As noted above, certain patients should avoid this product: those with a known hypersensitivity to acyclovir or any excipients in the cream, and individuals with active bacterial skin infections at the intended application site, because the drug does not treat bacterial pathogens. Pregnant or breastfeeding women should consult their obstetrician; existing data do not show teratogenic risk, but caution is reasonable given limited systemic absorption.
For patients who prefer a non-oral route due to swallowing difficulties or gastrointestinal side effects from tablets, the cream offers a convenient alternative. Its localized action also means fewer systemic adverse events, making it a favorable choice for patients on multiple chronic medications.
Taking Acyclovir Cream 5 % Effectively
Apply a thin layer of the cream to the affected area five minutes before the first sign of tingling, itching, or redness, and repeat every 12 hours for a total of five days, unless instructed otherwise by your clinician. The medication should be gently massaged into the lesion until it disappears; excessive rubbing can irritate fragile skin and compromise the barrier that the drug needs to penetrate.
Do not apply the cream to intact, unbroken skin distant from the lesion, as this offers no therapeutic benefit and may increase the risk of local irritation. If the lesion is located near the eyes, mouth, or other mucosal surfaces, use only a fingertip amount and avoid contact with the eyes-acyclovir is not formulated for ocular use.
When a dose is missed, apply it as soon as you remember provided that no more than 12 hours have elapsed; otherwise, skip the missed dose and continue with the regular schedule. Doubling the dose to “catch up” does not improve outcomes and may raise the likelihood of skin irritation.
Maintain a consistent routine-setting an alarm or pairing the application with a daily activity (e.g., brushing teeth) helps adherence. If you travel, keep the tube in a cool, dry place; the cream is stable at room temperature up to 25 °C, but prolonged exposure to high humidity can affect texture.
Understanding Side Effects and How to Manage Them
Because systemic absorption is minimal, most adverse events are local. Patients occasionally report mild burning, stinging, or itching at the site of application, especially when the skin is already inflamed. These sensations typically subside within a few minutes; applying a thin layer and allowing it to dry before covering the area can lessen discomfort.
If the skin becomes redder, swollen, or develops a rash extending beyond the original lesion, this may signal an allergic response to the cream’s vehicle. In such cases, discontinue use immediately and cleanse the area with mild soap and water. A healthcare professional should evaluate the reaction; antihistamines can be prescribed if the response is moderate, while severe swelling or difficulty breathing warrants urgent medical attention.
Rarely, deep ulceration or secondary bacterial infection can occur if the lesion is heavily scratched or if hygiene is poor. Acyclovir does not protect against bacterial colonization, so keeping the area clean and avoiding contact with contaminated objects is essential. Should signs of bacterial infection appear-purulent discharge, increasing pain, fever-seek medical care promptly, as oral or topical antibiotics may be required.
Buying Acyclovir Cream 5 % from Our Online Pharmacy
Why Choose Our Service?
Our platform connects you with licensed international pharmacies that stock authentic Acyclovir cream 5 % at prices close to wholesale rates. By eliminating unnecessary middlemen, we help you secure the medication you need without the typical markup found in brick-and-mortar stores.
Quality & Safety
We partner exclusively with pharmacies that hold valid licenses from recognized regulatory bodies such as the UK Medicines and Healthcare products Regulatory Agency (MHRA) and Singapore’s Health Sciences Authority (HSA). Every batch is verified for authenticity, potency, and compliance with Good Manufacturing Practices, ensuring you receive a product that meets stringent quality standards.
Pricing & Access
The 5 g tube is priced competitively, often 30-40 % lower than conventional local retail prices. For larger 10 g tubes, the cost per gram drops further, offering a cost-effective solution for patients who experience frequent outbreaks. If you prefer a brand-name alternative, we also stock Zovirax 5 % cream, allowing you to choose based on personal preference.
Discreet Delivery
All orders are shipped in unmarked, tamper-evident packaging that protects the product from temperature fluctuations. Express delivery typically arrives within 7 business days, while standard airmail takes 3 to 4 weeks. Our tracking system lets you monitor the parcel’s progress from departure to doorstep.
By offering a secure, private, and affordable route to Acyclovir cream 5 %, our service empowers you to manage your HSV episodes on your own schedule.
Frequently Asked Questions
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How soon after a tingling sensation should I apply the cream? Applying the medication within the first 2-4 hours of prodrome provides the greatest reduction in lesion size and duration, as it stops viral replication before vesicle formation.
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Can I use the cream on my genitals for HSV-2 outbreaks? While the product is primarily approved for oral lesions, clinicians sometimes prescribe it for mild genital sores when systemic therapy is contraindicated. Discuss this option with your physician to ensure proper use.
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Will the cream prevent transmission to my partner? Topical acyclovir reduces viral shedding locally but does not eliminate the risk of transmission. Using condoms and abstaining from oral-genital contact during active lesions remain essential preventive measures.
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Is it safe to combine the cream with oral acyclovir? Yes, the two forms act at different sites and have complementary mechanisms. Combining them may accelerate healing, particularly in severe or widespread outbreaks.
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What should I do if I forget a dose? Apply the missed dose as soon as you remember if it is within 12 hours of the scheduled time; otherwise, skip it and continue with the regular dosing interval.
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Can I apply the cream to a herpes zoster rash? Off-label use for shingles crusts has shown modest benefit in case reports, but it should only be done under the supervision of a dermatologist or infectious disease specialist.
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Is the cream suitable for children? The formulation is approved for adults; pediatric use requires dosage adjustment and medical oversight, as safety and efficacy data in children are limited.
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Will the cream work on a cold sore that has already crusted over? Once the lesion is fully crusted, viral replication has largely ceased, and the benefit of antiviral therapy diminishes. Early application yields the best results.
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How does Acyclovir cream differ from over-the-counter remedies? Over-the-counter products typically contain docosanol or lip balms that provide symptomatic relief, whereas Acyclovir actively inhibits viral DNA synthesis, shortening the infection’s course.
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Do I need to continue using the cream after the lesion heals? No, treatment is generally limited to a 5-day course. Continuing beyond the recommended duration does not confer additional benefit and may increase irritation risk.
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Can I store the cream in the bathroom? Moisture and heat can degrade the vehicle; keep the tube in a cool, dry place away from direct sunlight to maintain potency throughout the treatment period.
Glossary
- Thymidine Kinase
- An enzyme produced by herpes viruses that adds a phosphate group to nucleoside analogues like acyclovir, initiating their activation to the antiviral triphosphate form.
- Triphosphate
- The fully phosphorylated form of a nucleoside analogue that competes with natural nucleotides during viral DNA synthesis, leading to premature termination of the DNA chain.
- Prodrome
- Early warning signs (tingling, itching, or burning) that precede the appearance of visible herpes lesions, indicating the virus is beginning to replicate locally.
- Good Manufacturing Practices (GMP)
- Regulatory standards that ensure pharmaceutical products are consistently produced and controlled to quality standards appropriate for their intended use.
- Off-label
- Use of a medication for an indication, route, or patient group that has not received formal regulatory approval, typically based on emerging evidence or clinical judgment.
Disclaimer
The information provided about Acyclovir cream 5 % is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Acyclovir cream 5 % for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
