Buy Strattera
Strattera
Strattera Properties
About Strattera
Strattera is a prescription medication approved in Singapore for the treatment of attention-deficit/hyperactivity disorder (ADHD) in children, adolescents, and adults. Its active ingredient, atomoxetine, works by selectively inhibiting the reuptake of norepinephrine, a neurotransmitter involved in attention regulation and impulse control. Unlike stimulant therapies, Strattera is not classified as a controlled substance and can be taken once or twice daily depending on the prescribed dose. The pill comes in strengths of 10 mg, 18 mg, 25 mg and 40 mg, allowing clinicians to tailor therapy to individual needs while monitoring response and tolerability.
What is Strattera?
Strattera is a brand-name formulation of the selective norepinephrine reuptake inhibitor atomoxetine, marketed globally by Eli Lilly. In Singapore, the Health Sciences Authority (HSA) has approved Strattera for ADHD, making it a prescription-only medication (POM). It belongs to the pharmacological class of non-stimulant ADHD agents and is indicated for patients who may not tolerate stimulants or for whom stimulants are contraindicated. The product is supplied as oral capsules (pill) in four dosage strengths, enabling incremental titration to achieve optimal symptom control.
How Strattera Works
Atomoxetine blocks the norepinephrine transporter (NET) on presynaptic neurons, preventing the reabsorption of norepinephrine back into the nerve terminal. By increasing extracellular norepinephrine levels in the prefrontal cortex, the drug enhances signal-to-noise ratios that underlie attention, working memory, and executive function. Unlike dopamine-focused stimulants, atomoxetine’s effect is primarily noradrenergic, which accounts for its lower abuse potential.
Key pharmacokinetic points:
- Absorption: Peak plasma concentrations are reached 1-2 hours after oral intake; food modestly delays absorption but does not affect overall exposure.
- Distribution: Highly bound to plasma proteins (~98 %).
- Metabolism: Primarily metabolised by CYP2D6; poor metabolizers experience higher plasma levels, necessitating dose adjustments.
- Elimination: Half-life averages 5 hours in extensive metabolizers and up to 21 hours in poor metabolizers; metabolites are renally excreted.
These characteristics support once-daily dosing for most adults, while some pediatric regimens start with twice-daily administration to maintain steadier plasma concentrations during titration.
Why Strattera is Used for ADHD Conditions
- Targeting Noradrenergic Deficits: Research links reduced norepinephrine activity in the prefrontal cortex with inattentiveness and impulsivity; increasing its availability directly addresses this pathophysiology.
- Non-Stimulant Option: For patients with comorbid anxiety, tic disorders, or a history of substance misuse, Strattera offers an effective alternative without the risk of dependence.
- Guideline Positioning: Both the American Academy of Pediatrics (AAP) and the European ADHD Guidelines list atomoxetine as a second-line agent, particularly when stimulants are ineffective or not tolerated.
- Dose Flexibility: The availability of multiple capsule strengths enables clinicians to start low (e.g., 10 mg) and incrementally increase to a target dose of 80 mg/day (or 1.4 mg/kg for children), improving tolerability.
- Duration of Action: A single dose provides symptom control for up to 12 hours, covering school or work days without the need for mid-day dosing in most cases.
Off-Label and Investigational Uses of Strattera
Evidence from small-scale trials and observational studies suggests potential benefits of atomoxetine in conditions such as generalized anxiety disorder, binge-eating disorder, and major depressive disorder. For example, a 12-week double-blind RCT reported modest reductions in anxiety scores among adults with comorbid ADHD and anxiety, though the effect was not replicated in larger cohorts. These uses remain off-label in Singapore, and any consideration should occur under the direct supervision of a qualified healthcare provider.
Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Strattera Right for You?
Strattera may be appropriate for individuals who:
- Have a confirmed ADHD diagnosis and have experienced side effects or limited efficacy with stimulant therapy.
- Require a medication with minimal abuse potential, such as patients with a personal or family history of substance use disorder.
- Present with comorbid anxiety or mild mood symptoms that could be aggravated by stimulant-induced sympathetic activation.
Caution is advised for patients with severe cardiovascular disease, uncontrolled hypertension, or narrow-angle glaucoma. Additionally, individuals known to be poor CYP2D6 metabolizers should begin at the lowest dose and may require alternate therapy if plasma concentrations become excessively high.
Taking Strattera Effectively
- Initial Dosing: Clinicians typically start with .5 mg/kg/day (rounded to the nearest capsule strength) and increase after 3-4 weeks to a target of 1.2-1.4 mg/kg/day, not exceeding 100 mg/day in adults.
- Timing: The capsule can be taken with or without food; consistency in timing helps maintain steady plasma levels.
- Missed Dose: If a dose is missed by less than 12 hours, take it as soon as remembered; otherwise, skip and resume the regular schedule-do not double-dose.
- Travel Considerations: When crossing time zones, maintain the same interval between doses rather than aligning with the new local time, and keep the medication in its original packaging with a copy of the prescription to avoid customs issues.
Understanding Side Effects and How to Manage Them
Most adverse events are related to the drug’s noradrenergic activity.
- Common Effects (≥10 %): Dry mouth, decreased appetite, nausea, insomnia, and mild dizziness. These often subside within the first two weeks as the body adapts. Managing strategies include staying hydrated, taking the capsule with a small snack, and avoiding caffeine late in the day.
- Cardiovascular Concerns: Increases in heart rate and blood pressure are dose-dependent. Patients should monitor their vitals during titration; if systolic pressure rises >10 mm Hg or diastolic >5 mm Hg, clinicians may adjust the dose or consider an alternative.
- Liver Function: Rare elevations in hepatic enzymes have been reported. Baseline liver tests are recommended before initiation, with periodic monitoring in patients with existing liver disease.
- Serious Reactions: Rare cases of suicidal ideation, especially in adolescents, have been documented. Immediate evaluation is required if mood changes, irritability, or new depressive symptoms emerge.
When side effects become intolerable, dose reduction or discontinuation under medical guidance is advised.
Buying Strattera from Our Online Pharmacy
Accessing Strattera through a reputable source can simplify treatment initiation, especially for patients facing pharmacy shortages or insurance constraints.
Why Choose Our Service?
Our online pharmacy partners with licensed international distributors to ensure authentic medication is delivered directly to your doorstep. By consolidating prescriptions and shipping, we reduce wait times and offer transparent pricing.
Quality & Safety
We work with suppliers that meet WHO Good Manufacturing Practice (GMP) standards and are regularly audited by regulatory agencies. Every batch is verified for potency and purity before dispatch.
Pricing & Access
Because Strattera is available as a generic in many markets, we can pass on considerable savings-up to 30 % lower than retail pharmacy rates. Returning customers enjoy a lifetime 10 % discount on all reorders, making long-term management more affordable.
Discreet Delivery
Orders are packaged in plain, tamper-evident containers. Express shipping typically arrives within 7 days, while standard delivery reaches most Singapore addresses within 3 weeks, all with full tracking.
Frequently Asked Questions
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What is the typical time frame to notice improvement with Strattera? Symptom reduction usually becomes evident after 4-6 weeks of consistent dosing, although some patients report early benefits within the first two weeks.
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Can Strattera be taken with stimulant medication? Co-administration is not routinely recommended because the combined noradrenergic and dopaminergic effects may increase cardiovascular stress. Any combination should be closely monitored by a specialist.
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Is a blood test required to check for CYP2D6 metabolism? Genetic testing is optional; most clinicians rely on clinical response and side-effect profile to infer metabolizer status.
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How does Strattera compare with Vyvanse in terms of efficacy? Head-to-head trials show comparable improvements in ADHD rating scales, but stimulants like Vyvanse often produce a faster onset of action, whereas Strattera offers a lower abuse risk.
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What should I do if I forget a dose while traveling across time zones? Keep the same interval between doses rather than adjusting to local time; if you miss a dose by more than 12 hours, skip it and resume the regular schedule.
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Are there any dietary restrictions while on Strattera? No specific foods must be avoided, but excessive caffeine may exacerbate insomnia or jitteriness.
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Can I breastfeed while taking Strattera? Atomoxetine is excreted in breast milk; current guidance advises against breastfeeding during treatment unless the benefits outweigh potential risks.
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What is the impact of Strattera on weight? Appetite suppression can lead to modest weight loss, particularly in children. Regular growth monitoring is recommended during long-term therapy.
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Is Strattera covered by Singapore’s Medisave or insurance schemes? Coverage varies by plan; many private insurers reimburse a portion of the cost with a physician’s prescription.
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How should I store the medication? Keep the capsules at room temperature, away from moisture and direct sunlight. Do not refrigerate or freeze.
Glossary
- Norepinephrine
- A neurotransmitter involved in attention, arousal, and stress responses; increased levels in the prefrontal cortex improve focus.
- CYP2D6
- A liver enzyme that metabolises many drugs, including atomoxetine; genetic variations influence drug clearance.
- GMP (Good Manufacturing Practice)
- International quality standards that ensure medicines are consistently produced and controlled according to quality criteria.
- POM (Prescription-Only Medication)
- A drug classification indicating that the product may be dispensed only with a valid medical prescription.
- Bioequivalence
- Demonstrates that a generic version releases the same amount of active ingredient into the bloodstream as the reference brand.
Disclaimer
The information provided about Strattera is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Strattera for individuals who may have limited availability through traditional prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
