Buy Compazine

Compazine

Compazine (prochlorperazine) is a prescription medication most often used to control severe nausea and vomiting, and at higher doses to treat certain psychotic disorders. Belonging to the phenothiazine class, it exerts its therapeutic effects by influencing dopamine pathways in the brain. In Singapore the drug is available as a 5 mg oral tablet, marketed under the brand name Compazine and supplied by pharmaceutical companies that hold approval from the Health Sciences Authority (HSA). While the primary indications focus on emesis and psychosis, clinicians sometimes employ the agent for migraine-associated nausea or for short-term sedation before surgery.

What is Compazine?

Compazine is the trade name for a phenothiazine-derived antipsychotic whose active ingredient is prochlorperazine. First introduced in the -s, prochlorperazine was developed as a “major tranquilizer” before its anti-emetic properties were recognised. The medication is classified both as an anti-psychotic and an anti-emetic, reflecting its dual ability to dampen overactive dopamine signalling in the limbic system and to block dopamine receptors in the chemoreceptor trigger zone of the brainstem. In Singapore, Compazine tablets are manufactured by licensed firms that meet HSA standards; generic versions containing the same active ingredient are also available at lower cost. The drug is prescription-only (Rx) and must be dispensed by a qualified prescriber.

How Compazine Works

Prochlorperazine’s primary mechanism centres on dopamine D₂ receptor antagonism. In the gastrointestinal tract, dopamine stimulates the chemoreceptor trigger zone (CTZ), sending signals to the vomiting centre. By binding to D₂ receptors in the CTZ, Compazine reduces the neuronal firing that initiates the reflexive act of vomiting. Simultaneously, within the central nervous system, the drug’s antagonistic action on dopamine pathways in the mesolimbic system diminishes psychotic symptoms such as hallucinations and delusions.

Pharmacokinetically, the tablet is rapidly absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours. Bioavailability is high, and food does not markedly alter absorption. Prochlorperazine is extensively bound to plasma proteins (≈ 90 %). Hepatic metabolism, primarily via CYP2D6, converts the drug into inactive metabolites that are excreted mainly in the urine. The elimination half-life ranges from 6 to 8 hours, supporting once- or twice-daily dosing depending on the clinical scenario. Because the drug is metabolised by CYP2D6, individuals who are poor metabolisers may experience higher plasma levels and consequently a greater risk of sedation or extrapyramidal symptoms.

Why Compazine Is Used for Nausea and Vomiting, Mental Health Conditions

• Chemotherapy-induced nausea and vomiting (CINV). The intense dopamine surge that follows cytotoxic drug administration triggers the CTZ. By blocking D₂ receptors, Compazine curtails this stimulus, often reducing vomiting episodes from several per day to none within the first 24 hours. Clinical guidelines from the Oncology Society of Singapore list phenothiazines as adjunctive agents when standard 5-HT₃ antagonists are insufficient.

• Post-operative and post-procedural nausea. After anesthesia, residual opioids and volatile agents can activate the CTZ. A single 5 mg dose of Compazine taken shortly before the end of surgery has been shown to lower the incidence of early post-operative emesis, allowing patients to resume oral intake sooner.

• Migraine-associated nausea. Migraine attacks frequently combine headache with severe nausea. Because dopamine pathways are implicated in migraine pathophysiology, an anti-dopaminergic agent like prochlorperazine offers dual relief-alleviating both pain and the accompanying gastrointestinal upset.

• Acute psychosis and schizophrenia (high-dose use). At doses above 10 mg, Compazine’s D₂ antagonism extends to mesolimbic circuits, dampening the positive symptoms of schizophrenia such as auditory hallucinations and thought disorder. Randomised trials have demonstrated comparable efficacy to other low-potency antipsychotics, albeit with a distinct side-effect profile.

• Severe refractory nausea from gastro-intestinal disorders. In conditions like gastroparesis or cyclic vomiting syndrome, conventional anti-emetics may fail. Adding a phenothiazine can provide symptom control when vagal afferent signalling is mediated by dopamine.

Off-Label and Investigational Uses of Compazine

In addition to its licensed indications, clinicians sometimes prescribe prochlorperazine for:

• Vertigo and motion sickness. Small case series have reported improvement in vertiginous episodes when standard antihistamines are ineffective, likely due to central dopamine blockade.
• Anxiety associated with severe nausea. The medication’s mild sedative properties may diminish anticipatory anxiety in patients undergoing repeated chemotherapy cycles.
• Adjunctive treatment for certain types of chronic hiccups. Dopaminergic pathways are thought to contribute to refractory hiccup syndromes; anecdotal reports suggest benefit from low-dose phenothiazines.

These applications remain off-label; any such use should occur only under the supervision of a qualified healthcare professional.

Is Compazine Right for You?

Compazine is generally appropriate for adults who need rapid control of vomiting or who have been diagnosed with a psychotic disorder that responds to low-potency antipsychotics. Patients with a known hypersensitivity to phenothiazines, a history of prolonged QT interval, or severe hepatic impairment should avoid the medication. Because the drug can exacerbate movement disorders, individuals with Parkinson’s disease, tardive dyskinesia, or a previous episode of extrapyramidal symptoms need careful evaluation before starting therapy. Pregnant or breastfeeding women must discuss potential risks with their obstetrician, as animal studies have shown fetal effects at high doses. Older adults may be more susceptible to sedation and orthostatic hypotension; dose adjustments or closer monitoring are advisable.

Taking Compazine Effectively

The tablet should be swallowed whole with a glass of water; crushing or chewing can alter the release profile and increase the risk of throat irritation. For nausea, the drug is usually taken before the anticipated emetic trigger-e.g., 30 minutes prior to chemotherapy or before the conclusion of surgery. When used for psychosis, the dose is often divided into two administrations to reduce peak-related side effects. Alcohol should be avoided, as it can potentiate CNS depression and increase dizziness. If a dose is missed, take it as soon as remembered unless it is within 6 hours of the next scheduled dose; in that case, skip the missed dose and continue the regular schedule. Consistency-taking the medication at the same times each day-helps maintain stable plasma concentrations and improves therapeutic outcomes.

Understanding Side Effects and How to Manage Them

Prochlorperazine’s dopamine blockade can produce several predictable adverse reactions. Sedation and dizziness stem from central nervous system depressant effects; patients should refrain from operating machinery until they know how the drug influences them. Extrapyramidal symptoms (such as muscle stiffness, tremor, or restlessness) arise from disrupted basal ganglia dopamine signalling. Early signs can be mitigated by adding an anticholinergic agent like benztropine, but any musculoskeletal discomfort warrants prompt medical review. Orthostatic hypotension may cause light-headedness upon standing-rising slowly and staying hydrated can reduce its impact. Rarely, prochlorperazine can prolong the QT interval, increasing the risk of ventricular arrhythmias; patients with known cardiac conduction disorders should have baseline ECG monitoring.

If any of the following occur, contact a healthcare professional without delay: high fever, severe muscle rigidity, uncontrolled tremor, signs of a serious allergic reaction (rash, swelling, breathing difficulty), or persistent inability to urinate. For mild dizziness or drowsiness, adjusting the timing of the dose (e.g., taking it in the evening) often suffices.

Buying Compazine from Our Online Pharmacy

Why Choose Our Service?

Our platform streamlines access to Compazine for Singapore residents who may face high local retail prices or limited pharmacy stock. By sourcing directly from licensed international suppliers, we keep costs close to manufacturing levels while maintaining strict quality control.

Quality & Safety

We partner exclusively with pharmacies that hold valid licenses from regulatory bodies such as the U.S. FDA, EMA, or Singapore’s HSA. Each shipment undergoes verification for authenticity, and the tablets are sealed in tamper-evident packaging to guard against contamination.

Pricing & Access

Generic prochlorperazine tablets are typically 30-40 % cheaper than the branded version, a margin we pass on to customers. For patients who need long-term therapy, we offer a 10 % discount on repeat orders. Should you require alternative anti-emetics, our catalogue also lists ondansetron, metoclopramide and granisetron, allowing you to discuss options with your prescriber.

Discreet Delivery

All parcels are packaged in unmarked, bubble-wrapped envelopes to protect the product and preserve privacy. Standard airmail delivery reaches most Singapore addresses within three weeks, while our express option arrives in about seven days, both with tracking numbers for peace of mind.

Frequently Asked Questions

• What is the typical onset of action for nausea relief? After swallowing a 5 mg tablet, most patients notice a reduction in vomiting within 30-60 minutes, with maximal effect achieved by the end of the first hour.

• Can Compazine be used together with other anti-emetics? Yes, clinicians often combine a phenothiazine with a 5-HT₃ antagonist for synergistic control of chemotherapy-induced nausea, provided the total dopamine antagonism does not exceed safety thresholds.

• Is there a risk of dependence or abuse? Prochlorperazine does not produce euphoric effects and lacks reinforcing properties, so it is not considered habit-forming. However, abrupt discontinuation after long-term high-dose therapy may precipitate withdrawal dyskinesia, so tapering under medical guidance is recommended.

• How should the medication be stored? Keep the tablets in a dry place at room temperature, away from direct sunlight and out of reach of children. No refrigeration is needed.

• Will taking Compazine affect my ability to drive? Sedation and dizziness are possible, especially during the first few doses. It is advisable to avoid driving or operating heavy machinery until you know how the drug influences you.

• Do I need blood tests while on Compazine? Routine monitoring is not mandatory for short-term use. For chronic therapy, periodic liver function tests and a baseline ECG are prudent, particularly in patients with cardiac risk factors.

• Can it be taken during pregnancy? The medication is classified as Pregnancy Category C in Singapore, indicating that risk cannot be ruled out. A prescriber will weigh the benefits of controlling severe nausea against potential fetal exposure.

• Why might I feel a metallic taste after taking the tablet? Minor taste disturbances are linked to the drug’s action on taste buds and are usually transient, resolving without intervention.

• What should I do if I accidentally double-dose? Contact a healthcare professional immediately. Though an isolated extra dose seldom leads to toxicity, monitoring for increased sedation or cardiac effects is essential.

Glossary

D₂ Receptor Antagonist

A compound that blocks dopamine D₂ receptors, reducing dopaminergic neurotransmission in the brain and peripheral nervous system.

Chemo-receptor Trigger Zone (CTZ)

An area in the medulla that detects blood-borne emetic agents and communicates with the vomiting centre to initiate nausea.

Extrapyramidal Symptoms (EPS)

Movement disorders-including rigidity, tremor, and restlessness-caused by interference with dopamine pathways in the basal ganglia.

Half-Life

The time required for the plasma concentration of a drug to decrease by 50 %; informs dosing intervals.

QT Prolongation

An extension of the heart’s electrical repolarisation period, which can predispose to dangerous arrhythmias if excessive.

Disclaimer

The information provided about Compazine is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Compazine for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

External Resources about Compazine

• Compazine (Prochlorperazine Oral) Advanced Patient Information - Drugs.com
• Prochlorperazine: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
• CZ:L96 PRESCRIBING INFORMATION COMPAZINE - Food and …
• Compazine: Uses, Dosage, Side Effects, Food Interaction & FAQ
• Prochlorperazine - Memorial Sloan Kettering Cancer Center