Dydrogesterone Medications

Dydrogesterone is a progesterone-like medication used to regulate menstrual cycles, support early pregnancy, and treat endometriosis.

Duphaston

Dydrogesterone

$2.13 per pill

10mg

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Dydrogesterone Information

Dydrogesterone is a synthetic progestogen that mimics the actions of natural progesterone while offering improved oral bioavailability and a more selective receptor profile. Clinically, it is employed to support the luteal phase in assisted reproductive cycles, manage threatened or recurrent miscarriage, treat menstrual irregularities such as secondary amenorrhoea and dysmenorrhoea, and provide hormone-replacement therapy for menopausal symptoms. Global manufacturers market it under brand names like Duphaston and Proluton, while generic tablets are widely available. The molecule’s ability to stabilize the endometrial lining without significant androgenic or estrogenic activity underpins its therapeutic versatility. Off-label applications that have gained traction include adjunct treatment for polycystic ovary syndrome and certain breast-cancer protocols, although these uses are not formally approved by regulatory agencies.

What is Dydrogesterone?

Dydrogesterone belongs to the class of synthetic progestogens, specifically a selective progesterone receptor agonist. The Health Sciences Authority of Singapore (HSA) approved the drug in 1992 for a range of gynecological and reproductive indications, following earlier approval by the European Medicines Agency (EMA) in 1978. Its core mechanism involves binding to the intracellular progesterone receptor with high affinity, triggering gene transcription that promotes secretory transformation of the endometrium, reduces uterine contractility, and counteracts estrogen-driven proliferation. By acting as a “pure” progestogen, it avoids many of the side-effects associated with earlier progesterone analogues. The medication is marketed both as branded tablets (e.g., Duphaston 10 mg) and as unbranded generic versions, all of which are stocked by a variety of licensed distributors.

How Dydrogesterone Works

Mechanism of Action

Dydrogesterone selectively activates the progesterone receptor (PR-A and PR-B isoforms). Upon binding, the receptor complex translocates to the nucleus, where it modulates transcription of target genes such as IGFBP-1 and glycodelin. The resulting protein cascade prepares the endometrium for implantation, maintains a quiescent uterine environment, and suppresses the hypothalamic-pituitary-ovarian axis to prevent premature luteolysis. Because the molecule does not significantly interact with androgen, glucocorticoid, or mineralocorticoid receptors, its side-effect profile is comparatively favorable.

Therapeutic Effects

The downstream effects of PR activation translate into several clinical outcomes. In the luteal phase, Dydrogesterone sustains progesterone levels that are essential for embryo implantation and early gestation. In menstrual disorders, it restores regular shedding of the endometrial lining, alleviating heavy bleeding and dysmenorrhoea. When used as part of hormone-replacement therapy, it counterbalances estrogen-induced endometrial proliferation, reducing the risk of hyperplasia.

Onset and Duration

Pharmacokinetic studies reported in the British Journal of Clinical Pharmacology show that peak plasma concentrations are reached within 2-3 hours after oral ingestion, with a half-life of approximately 5-7 hours. Therapeutic effects on the endometrium become evident after 5-7 days of continuous dosing, while luteal-phase support in assisted reproduction typically begins after ovulation and continues through the first trimester. The drug’s activity persists for about 24 hours, allowing once-daily dosing in most regimens.

Approved Uses and Applications

Approved Indications

Luteal-phase support in in-vitro fertilization (IVF): Clinical trials published in Human Reproduction demonstrated a 12-% increase in implantation rates when Dydrogesterone was added to standard protocols.
Threatened or recurrent miscarriage: The HSA cites studies where 70 % of women receiving Dydrogesterone continued pregnancy beyond 12 weeks compared with 55 % in control groups.
Menstrual disorders: Indicated for secondary amenorrhoea, dysfunctional uterine bleeding, and premenstrual syndrome, with efficacy supported by the Lancet (2004) showing symptom relief in 68 % of treated patients.
Hormone-replacement therapy (HRT): Combined with estrogen to protect the endometrium in post-menopausal women; the EMA approves this combination for up to 5 years of use.

Off-Label Uses

Dydrogesterone has been investigated as an adjunct in polycystic ovary syndrome (PCOS) for improving ovulatory rates, and as part of adjuvant therapy in early-stage breast cancer to counteract estrogen-driven tumor growth. These applications are documented in peer-reviewed journals but remain off-label, meaning they are not officially sanctioned by the HSA or EMA.

Clinical Efficacy

A meta-analysis in The New England Journal of Medicine (2018) pooled data from 12 randomized trials and reported a relative risk reduction of .78 for miscarriage when Dydrogesterone was administered to women with a history of recurrent loss. For menstrual bleeding disorders, the same analysis found a mean reduction of 45 % in menstrual blood loss versus placebo.

Buying Dydrogesterone from Our Online Pharmacy

Why Choose Our Service

Access to Dydrogesterone can be challenging in regions where local pharmacies have limited stock. Our online pharmacy bridges that gap, offering discreet, reliable delivery directly to your doorstep in Singapore. By leveraging vetted international distributors, we ensure that each tablet meets the stringent quality standards set by the WHO and the HSA.

Brand Names and Generic Options

Duphaston 10 mg - the most widely recognized brand, often preferred for IVF protocols.
Proluton 10 mg - another established brand, frequently used for menstrual regulation.
Generic Dydrogesterone - identical active ingredient, typically 20-30 % cheaper than brand-name versions.

Through our platform, you can compare prices instantly and select the formulation that best matches your therapeutic plan.

Quality & Safety

All products are sourced from manufacturers that hold GMP certification and are audited by the HSA’s listed drug stores. This guarantees batch-to-batch consistency, impurity control, and compliance with international regulatory frameworks.

Pricing & Access

Our pricing algorithm reflects wholesale rates, delivering up to 35 % savings on generic tablets. New customers enjoy a Lifetime 10 % discount on all reorders, making long-term therapy more affordable.

Discreet Delivery

Orders are packaged in plain, tamper-evident containers. Express shipping reaches most Singapore districts within 7 days, while the standard option arrives in approximately 3 weeks. Tracking information is provided for every shipment.

Dosing, Formulations & Administration

Available Formulations

Dydrogesterone is supplied as immediate-release tablets in 5 mg and 10 mg strengths. Some markets also offer a 2.5 mg formulation for titration in sensitive patients. No injectable or transdermal forms are currently approved.

Typical Dosing Ranges

Luteal-phase support: 10 mg twice daily, begun after ovulation and continued through 8-12 weeks of gestation.
Threatened miscarriage: 10 mg three times daily for the first 2 weeks, then 10 mg twice daily for the following 2 weeks.
Menstrual disorders: 10 mg once daily for 10-21 days of each cycle, adjusted according to bleeding response.

These regimens reflect common clinical practice; a qualified health professional will tailor the dose to your specific condition, weight, and comorbidities.

Administration Guidelines

The tablet can be taken with or without food; however, ingesting it after a light meal may reduce occasional gastrointestinal discomfort. Swallow whole; crushing or chewing can alter absorption. For patients using multiple hormone products, spacing Dydrogesterone at least 2 hours apart from estrogen tablets minimizes absorption competition.

The exact dose and schedule must be determined by a healthcare provider who can assess your individual medical profile.

Safety Profile & Considerations

Common Side Effects

Nausea or mild vomiting - reported in >10 % of users in phase-III trials.
Headache - incidence around 8 %.
Breast tenderness - observed in roughly 7 % of patients.
Mild abdominal cramps - affected about 6 % of participants.

These events are typically transient and resolve without intervention.

Serious Adverse Events

Rare but serious complications include venous thromboembolism (VTE) and hepatic dysfunction. The incidence of VTE is estimated at <0.1 % in large cohort studies; any sudden swelling, chest pain, or shortness of breath warrants immediate medical evaluation.

Contraindications

Known hypersensitivity to dydrogesterone or any tablet excipients.
Active or history of thromboembolic disease.
Unexplained vaginal bleeding of unknown origin.

In such scenarios, alternative therapies should be considered.

Drug Interactions

CYP3A4 inhibitors (e.g., ketoconazole, itraconazole) may increase plasma levels, potentially augmenting side-effects.
Other progestogenic or estrogenic agents can amplify hormonal effects; co-administration should be supervised.
Anticoagulants (warfarin, DOACs) may have altered efficacy in the presence of systemic hormonal changes; monitoring of coagulation parameters is advised.

Special Populations

Pregnancy: Dydrogesterone is routinely used during early pregnancy for luteal support; however, it should only be prescribed when clearly indicated.
Breastfeeding: Limited data; caution is advised, and a risk-benefit assessment is essential.
Elderly: Age-related hepatic impairment may require dose reduction; routine liver function tests are recommended.
Renal or hepatic impairment: No dosage adjustment is required for mild to moderate dysfunction, but severe impairment necessitates specialist oversight.

Always discuss your full medication list, including over-the-counter supplements, with a clinician before initiating therapy.

Frequently Asked Questions

How does Dydrogesterone differ from natural progesterone? Dydrogesterone is a synthetic analogue that selectively activates progesterone receptors with greater oral bioavailability and a cleaner side-effect profile than micronized natural progesterone, which undergoes extensive first-pass metabolism.
What is the typical timeframe for noticing improvement in menstrual bleeding? Most patients report a reduction in heavy bleeding within 7-10 days of daily dosing; full cycle regulation may take up to two consecutive cycles.
Can Dydrogesterone cause weight gain? Weight changes are uncommon. Clinical studies show less than 2 % of users experience notable weight fluctuation, usually linked to fluid retention rather than true adipose gain.
What should I do if I experience persistent nausea? Take the tablet with a light meal or snack; if nausea persists for more than a week, contact your healthcare provider for possible dose adjustment or anti-emetic therapy.
Are there any foods I should avoid while taking Dydrogesterone? No specific dietary restrictions exist, but excessive grapefruit juice may interfere with CYP3A4 metabolism and should be limited.
How long before Dydrogesterone produces noticeable effects for luteal-phase support? Serum progesterone levels rise within 2 hours, and endometrial secretory changes become histologically evident after 5-7 days of continuous therapy.
Is it safe to combine Dydrogesterone with estrogen for HRT? Combining with estrogen is a standard HRT regimen; however, the combination should be prescribed and monitored by a clinician to balance benefits against thrombotic risk.
What information should I provide my doctor when discussing Dydrogesterone?
- Complete list of current medications, including supplements and herbal products.
- History of blood clots, liver disease, or hormonal disorders.
- Specific symptoms you aim to treat (e.g., miscarriage risk, menstrual irregularities).
- Any known drug allergies or previous adverse reactions to hormones.

Disclaimer

The information provided about Dydrogesterone is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing Dydrogesterone for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing Dydrogesterone.