Buy Duphaston
Duphaston
Duphaston Properties
About Duphaston
Duphaston is a synthetic progestogen prescribed to support the luteal phase of the menstrual cycle, manage menstrual irregularities, and aid hormone-replacement therapy in women. Containing dydrogesterone, it mimics natural progesterone’s actions on the uterus and breast tissue, helping to stabilize the endometrium and maintain pregnancy-compatible conditions. In Singapore, Duphaston is a prescription-only medication approved for several gynecological and reproductive indications, and it is commonly used under the guidance of obstetricians and gynecologists.
What is Duphaston?
Duphaston is the brand name for dydrogesterone, a selective progesterone receptor agonist developed by Abbott Laboratories. Classified within the progestogen class, it is approved by the Health Sciences Authority of Singapore for luteal-phase support in assisted reproductive technology, treatment of menstrual disorders such as secondary amenorrhea, and as part of hormone-replacement therapy (HRT) for menopausal symptoms. The tablet formulation delivers a precise 10 mg dose, designed for oral administration once or twice daily depending on the indication. Because it is a brand product, it is distinguished from generic dydrogesterone by its validated bioequivalence, manufacturing standards, and consistent clinical data.
How Duphaston Works
Dydrogesterone binds selectively to the intracellular progesterone receptor, activating the same genomic pathways as endogenous progesterone but with a more favorable side-effect profile. Upon oral ingestion, the tablet is rapidly absorbed, reaching peak plasma concentrations within 1-2 hours. It undergoes hepatic metabolism primarily via CYP3A4, producing inactive metabolites that are excreted in the urine. The biological half-life of 10-16 hours permits steady-state levels with once-daily dosing for most indications.
By engaging progesterone receptors in the endometrium, Duphaston promotes secretory transformation, suppresses proliferative estrogen-driven growth, and prepares the uterine lining for implantation. In the breast, it counteracts estrogen-induced proliferation, contributing to its safety profile in HRT regimens. Moreover, progesterone receptor activation modulates the hypothalamic-pituitary-ovarian axis, helping to regulate the luteal phase and reduce menstrual bleeding.
Why Dudhaston is Used for Hormone Therapy, Women’s Health Conditions
- Luteal-Phase Support in IVF - The medication sustains the endometrial environment after embryo transfer, improving implantation rates. Guidelines from the European Society of Human Reproduction and Embryology recommend progestogen supplementation as a standard adjunct to ovarian stimulation protocols.
- Secondary Amenorrhea & Irregular Cycles - By mimicking natural progesterone, Duphaston restores cyclic endometrial shedding, reducing episodes of prolonged bleeding or amenorrhea. Clinical trials show a 70 % resolution rate in patients with hypothalamic-pituitary dysfunction.
- Endometriosis-Associated Pain - Progesterone resistance in endometrial tissue contributes to ectopic implantation. Duphaston’s selective receptor activation diminishes ectopic growth and alleviates dysmenorrhea, as demonstrated in randomized studies comparing it to norethisterone.
- Premenstrual Syndrome (PMS) - Stabilization of the luteal phase curtails mood swings and breast tenderness. Meta-analysis indicates a modest but statistically significant reduction in PMS severity scores.
- Menopausal Hormone-Replacement Therapy - When combined with estrogen, Duphaston protects the endometrium from estrogen-induced hyperplasia, allowing safe systemic HRT. The International Menopause Society cites progestogen-containing regimens as the preferred approach for women with an intact uterus.
Off-Label and Investigational Uses of Duphaston
Evidence from small-scale trials suggests potential benefits of dydrogesterone in polycystic ovary syndrome (PCOS) for improving ovulatory rates, and in the prevention of preterm birth when administered to women with a history of spontaneous preterm delivery. Although these studies are peer-reviewed, regulatory agencies in Singapore have not granted formal approval for these indications. Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Duphaston Right for You?
Duphaston suits women who require progesterone support for fertility treatments, menstrual regulation, or menopausal hormone therapy. Ideal candidates include those with a confirmed luteal-phase deficiency, endometrial hyperplasia secondary to estrogen exposure, or women undergoing assisted reproductive technology. Special consideration is needed for patients with hepatic impairment (dose adjustment may be required), a history of thromboembolic disease (use with caution), or active breast cancer (contraindicated). Pregnant women should only use Duphaston when explicitly prescribed for luteal support; routine use in early pregnancy without indication is discouraged.
Taking Duphaston Effectively
For luteal-phase support, the typical regimen is 10 mg twice daily, beginning after ovulation or embryo transfer and continuing for 10-14 days. When treating menstrual disorders, a single 10 mg dose taken at night for 10 consecutive days each cycle is common. The tablet should be swallowed whole with water; crushing may alter absorption. Food does not significantly affect bioavailability, but a high-fat meal can modestly delay peak concentrations. If a dose is missed, take it as soon as remembered unless it is within 12 hours of the next scheduled dose-then skip the missed tablet to avoid double dosing. For travel, keep tablets in their original packaging and store them at room temperature, away from moisture.
Understanding Side Effects and How to Manage Them
Common adverse effects-mild nausea, headache, and breast tenderness-stem from progesterone receptor activation in the gastrointestinal tract and breast tissue. Taking the tablet with food can reduce nausea, while a short-term analgesic may ease headache. Vaginal spotting occurs in up to 15 % of users when initiating therapy; this usually resolves as the endometrium stabilizes. Rare but serious reactions include allergic dermatitis, hepatic dysfunction, and signs of thromboembolism (e.g., sudden leg swelling, chest pain). Patients experiencing severe abdominal pain, unexplained bleeding, or symptoms of a blood clot should seek immediate medical attention. Monitoring liver enzymes during prolonged therapy is advisable, especially in individuals with pre-existing hepatic disease.
Buying Duphaston from Our Online Pharmacy
Access to Duphaston can be challenging through conventional Singaporean pharmacies due to limited stock and prescription-only restrictions. Our online pharmacy bridges that gap, offering a discreet and reliable channel to obtain the medication.
Why Choose Our Service?
Our service provides a convenient, secure platform for patients who need timely access to prescription-only hormone therapy. By partnering with licensed international pharmacies, we ensure that every product meets stringent quality standards.
Quality & Safety
We work only with suppliers that comply with WHO Good Manufacturing Practices and are authorized by the Health Sciences Authority of Singapore. Each batch undergoes independent verification to guarantee authenticity.
Pricing & Access
Competitive pricing on Duphaston tablets helps reduce the financial burden of long-term hormone therapy. Generic dydrogesterone alternatives are also listed, offering up to 30 % savings while maintaining equivalent efficacy. A lifetime 10 % discount applies to all reorders, encouraging continuity of care.
Discreet Delivery
Orders are shipped in neutral packaging, with express delivery arriving in approximately 7 days and standard delivery within 3 weeks. Tracking information is provided to maintain transparency while protecting patient privacy.
Frequently Asked Questions
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Can Duphaston be used to prevent miscarriage? Clinical trials have shown that luteal-phase support with dydrogesterone may lower the risk of early pregnancy loss in women with documented progesterone deficiency. However, it should only be prescribed after a thorough obstetric evaluation.
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Is it safe to take Duphaston while breastfeeding? Small studies indicate minimal transfer of dydrogesterone into breast milk, and no adverse effects have been reported in infants. Nonetheless, lactating mothers should discuss continuation with their healthcare provider.
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How does Duphaston differ from natural progesterone supplements? Dydrogesterone is a selective progesterone receptor agonist with higher oral bioavailability and fewer androgenic side effects compared to micronized natural progesterone, which often requires higher doses and multiple daily administrations.
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What should I do if I experience severe headache while on Duphaston? While mild headache is common, a severe or persistent headache may signal elevated blood pressure or other complications. Seek medical evaluation promptly to rule out serious causes.
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Can Duphaston be combined with estrogen in hormone-replacement therapy? Yes; in HRT regimens for women with an intact uterus, Duphaston protects against estrogen-induced endometrial hyperplasia, permitting safe systemic estrogen therapy.
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Is there a risk of weight gain with Duphaston? Unlike some progestins, dydrogesterone has little impact on fluid retention or appetite. Most patients report no significant change in body weight during therapy.
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How long can I stay on Duphaston for menstrual regulation? Treatment courses generally last 10-14 days per cycle, repeated for up to three cycles until regularity is achieved. Longer use should be monitored by a physician to assess efficacy and safety.
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What alternatives exist if Duphaston is unavailable? Other progestogens such as micronized progesterone, norethisterone, or medroxyprogesterone acetate can be considered, but each has distinct pharmacokinetic profiles and side-effect spectra. A clinician can tailor the choice to individual needs.
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Does Duphaston interact with common medications? Dydrogesterone is metabolized by CYP3A4; concomitant use of strong inducers (e.g., rifampin) or inhibitors (e.g., ketoconazole) may alter its plasma levels. Review all current medications with your prescriber.
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Can I travel internationally with Duphaston tablets? Yes, provided you carry a copy of the prescription and keep the medication in its original labeled container. Some countries may require a medical certificate; verify regulations before departure.
Glossary
- Progesterone Receptor: A cellular protein that, when bound by progesterone or synthetic analogues, triggers gene expression changes controlling uterine lining development.
- Luteal Phase: The post-ovulatory segment of the menstrual cycle characterized by progesterone secretion to prepare the endometrium for potential implantation.
- Bioequivalence: Demonstration that two drug products release the same amount of active ingredient into the bloodstream at comparable rates, ensuring similar therapeutic effects.
- CYP3A4: An enzyme in the liver responsible for metabolizing many drugs, including dydrogesterone; its activity can be altered by other medications or substances.
- Hormone-Replacement Therapy (HRT): Treatment involving estrogen, with or without a progestogen, to alleviate menopausal symptoms and prevent long-term estrogen-related complications.
Disclaimer
The information provided about Duphaston is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Duphaston for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
