Fenofibrate Medications
Fenofibrate is a fibrate medication used to treat high cholesterol and triglyceride levels by activating peroxisome proliferator-activated receptors.
About Fenofibrate
Fenofibrate is a lipid-modifying classified as a fibric acid derivative. It is primarily prescribed to lower elevated triglyceride levels and to improve the overall lipid profile in adults with primary or mixed dyslipidaemia. By activating the nuclear receptor peroxisome proliferator-activated receptor-α (PPARα), fenofibrate enhances the catabolism of triglyceride-rich lipoproteins and modestly raises high-density lipoprotein (HDL) cholesterol. The drug is marketed worldwide under brand names such as Tricor, Lofibra, and Antara, while generic fenofibrate tablets are widely available through our online pharmacy. In Singapore, the Health Sciences Authority approved fenofibrate for the treatment of hypertriglyceridaemia and mixed hyperlipidaemia, reflecting its established role in reducing cardiovascular risk when triglycerides are markedly elevated. Off-label, clinicians sometimes use fenofibrate to address severe hypercholesterolaemia resistant to statins, although such use is not officially sanctioned.
What is Fenofibrate?
Fenofibrate belongs to the fibric acid class of lipid-lowering drugs. The Singapore Health Sciences Authority granted its first approval in 2003 for the treatment of primary hypertriglyceridaemia, and subsequent amendments expanded the indication to mixed dyslipidaemia. The United States FDA and the European Medicines Agency (EMA) list the same therapeutic scope, confirming its global regulatory consensus. At the molecular level, fenofibrate acts as a selective agonist of the peroxisome proliferator-activated receptor-α (PPARα). Activation of PPARα up-regulates genes involved in fatty-acid oxidation, increases lipoprotein lipase activity, and suppresses hepatic very-low-density lipoprotein (VLDL) synthesis, collectively lowering plasma triglycerides and modestly raising HDL-cholesterol. Both branded formulations and generic tablets are dispensed through our pharmacy service, offering patients flexibility in cost and packaging.
How Fenofibrate Works
Mechanism of Action
Fenofibrate binds to the ligand-binding domain of PPARα, a nuclear transcription factor expressed mainly in liver, heart, muscle, and kidney. This binding triggers heterodimer formation with retinoid X receptor, initiating transcription of genes that promote β-oxidation of fatty acids, enhanceoprote lip synthesis, and reduce apolipoprotein C-III production. The net effect is accelerated clearance of triglyceride-rich particles from circulation.
Therapeutic Effects
By accelerating catabolism of VLDL andylomicrons, fenofibrate reduces fasting and post-prandial triglyceride concentrations, often by 30-50 %. Increased lipoprotein lipase activity also facilitates the conversion of VLDL to LDL, which, together with a modest rise in HDL, improves the atherogenic lipid profile. Clinically, these changes translate into a lower incidence of pancreatitis and, in selected high-risk groups, a modest reduction in cardiovascular events.
Onset and Duration
Pharmacokinetic studies show that steady-state plasma concentrations are reached within 7-10 days of daily dosing. a measurable drop in triglycerides after 2 weeks, with maximal effect observed between 4 and 8 weeks. The drug’s half-life ranges from 12 to 20 hours; once-daily dosing maintains therapeutic levels throughout the day.
Approved Uses and Applications
Approved Indications
- Primary hypertriglyceridaemia - reduction of fasting triglycerides ≥ 200 mg/dL. (H)- Mixed dyslipidaemia - combined elevation of triglycerides and low HDL-C. (FDA, EMA)
- Adjunct therapy for patients with severe hypercholesterolaemia who cannot achieve target LDL-C with statins alone. (Off-label, supported by clinical observations)
Off-Label Uses
Fenofibrate has been explored for slowing progression of diabetic retinopathy and for treating non-alcoholic fatty liver disease (NAFLD). Small cohort studies reported improvements in retinal microvascular leakage and hepatic steatosis scores, yet these applications remain unapproved by major regulatory agencies.
Clinical Efficacy
A pivotal trial published in The New England Journal of Medicine demonstrated a 49 % mean reduction in triglycerides and a 10 % rise in HDL-C after 12 weeks of fenofibrate therapy versus placebo (p < .001). The FIELD study cohort, spanning over 9 years, showed a 16 % relative risk reduction in cardiovascular events among type 2 diabetic patients receiving fenofibrate compared with standard care.
Buying Fenofibrate from Our Online Pharmacy
Why Choose Our Service
Access to fenofibrate can be hindered by limited stock in some local dispensaries. Through our platform, patients in Singapore receive discreet, rapid without compromising quality. Competitive pricing and a streamlined ordering process make it easier to stay on therapy.
Brand Names and Generic Options
- Tricor® - 145 mg tablets
- Lofibra® - 200 mg tablets
- Antara® - fenofibric acid formulation (similar efficacy)
- Generic fenofibrate - 135 mg, 160 mg, and 200 mg strengths, often at 30-40 % lower cost than brand equivalents.
Quality & Safety
We partner with licensed international pharmacies that adhere to WHO Good Manufacturing Practice standards, ensuring each batch meets stringent purity criteria.
Pricing & Access
Generic fenofibrate tablets start at S$.12 per tablet, while branded options range from S$.30 to S$.45. All repeat orders receive a Lifetime 10 % discount, helping patients maintain long-term therapy affordably.
Discreet Delivery
Express shipping arrives within 7 days, and standard delivery within three weeks. Packages are sealed in unmarked, tamper-evident envelopes to protect privacy.
Dosing, Formulations & Administration
Available Formulations
Fenofibrate is supplied as oral tablets (135 mg, 160 mg, 200 mg) and as micronized capsules designed for enhanced absorption. Some formulations combine fenofibrate with statins, but those combinations are not the focus of this overview.
Typical Dosing Ranges
For adults with primary hypertriglyceridaemia, clinicians usually initiate therapy at 145 mg once daily with the main meal. In cases of mixed dyslipidaemia, doses of 160 mg 200 mg may be titrated based lipid response and tolerance. Dose adjustments are guided by periodic lipid panels and liver function tests.
Administration Guidelines
Fenofibrate should be taken with food to improve bioavailability. Switching between immediate-release and micronized products requires a 48-hour washout to avoid fluctuating plasma levels. severe impairment may need a reduced dose or alternative therapy. Ultimately, the exact regimen must be individualized by a qualified healthcare professional.
Safety Profile & Considerations
Common Side Effects
- Gastro-intestinal upset (nausea, abdominal pain) - reported in ~15 % of users.
- Elevation of liver enzymes - observed in 5-10 % of patients, typically transient.
- Muscle pain or weakness - occurs in 3-5 % and warrants monitoring, especially when combined with statins.
Serious Adverse Events
Rare cases of rhabdomyolysis have been documented, particularly in patients with pre-existing renal dysfunction or concomitant strong CYP3A4 inhibitors. Acute pancreatitis has also been reported, albeit infrequently (<0.1 %). Immediate medical evaluation is essential if severe muscle tenderness, dark urine, or sudden abdominal pain develop.
Contraindications
- Active liver disease or unexplained persistent elevation of transaminases.
- Severe renal impairment (creatinine clearance < 30 mL/min).
- Known hypersensitivity to fenofibrate or any excipients.
Drug Interactions
- CYP450 inhibitors such as gemfibrozil markedly increase fenofibrate plasma levels; co-administration is contraindicated.
- Statins - concomitant use raises the risk of myopathy; dose reduction of the statin or close monitoring of creatine kinase is advised.
- Anticoagulants - fenofibrate may potentiate the effect of warfarin, necessitating more frequent INR checks.
Special Populations
- Pregnancy & Breastfeeding - animal show adverse fetal outcomes; fenofibrate is generally avoided unless benefits outweigh risks.
- Elderly - increased susceptibility to hepatic enzyme elevation and muscle toxicity; start at the lowest effective dose.
- Hepatic impairment - baseline liver function tests are required; dose adjustments may be needed.
Frequently Asked Questions
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How does fenofibrate differ from gemfibrozil? Fenofibrate has a longer half-life, higher potency for triglyceride reduction, and a more favorable interaction profile with statins with gemfibrozil- What is the typical timeline for fenofibrate to lower triglycerides? Most patients observe a measurable decline within 2 weeks, with the greatest reduction occurring between 4 and 8 weeks of consistent therapy.
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Can I take fenofibrate with my morning coffee? Fenofibrate should be taken with a meal; coffee does not interfere with absorption, but a substantial fat-containing meal enhances bioavailability.
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What should I do if I develop muscle soreness while on fenofibrate? Report the symptom to your healthcare provider promptly. They may order a creatine kinase test and consider dose adjustment or switching therapy.
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Are there foods I should avoid while taking fenofibrate? High-fat meals improve absorption, so no specific restrictions exist. However, maintaining a balanced diet low in saturated fat supports overall lipid control.
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Is fenofibrate safe for people with a history of gallstones? Fenofibrate can increase the risk of biliary sludge and gallstone formation; patients with a prior gallstone history should discuss alternatives with their clinician.
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How does fenofibrate impact cardiovascular risk in diabetics? The FIELD study indicated a modest 16 % relative risk reduction in major cardiovascular events among type 2 diabetics receiving fenofibrate, primarily driven by triglyceride lowering.
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Can I buy fenofibrate online in Singapore? Yes, you can purchase fenofibrate from our online pharmacy, which offers both branded and generic options with discreet delivery.
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What information should I provide my doctor when discussing fenofibrate?
- Complete list of current medications, including over-the-counter drugs and supplements.
- Recent laboratorylipid panel, liver and renal function).
- History of liver disease, kidney impairment, or muscle disorders.
- Any previous adverse reactions to lipid-lowering agents.
Disclaimer
The information provided about fenofibrate is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing fenofibrate for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing fenofibrate.
