Medroxyprogesterone Medications

Medroxyprogesterone is a synthetic progestogen used to treat a range of hormonal disorders and provide long-acting contraception. It belongs to the class of progesterone analogues that bind to the progesterone receptor, suppressing ovulation and stabilizing the endometrium. In Singapore, the Health Sciences Authority (HSA) has approved medroxyprogesterone acetate for intramuscular injection as a contraceptive (Depo-Provera) and for oral therapy of abnormal uterine bleeding and certain hormone-responsive cancers. Brand names such as Depo-Provera, Provera, and Medroxy-L are widely available, and generic formulations can be purchased through our online pharmacy. Off-label, clinicians sometimes employ medroxyprogesterone for endometrial hyperplasia or menopausal hormone therapy, though these uses are not officially sanctioned. Understanding its mechanism, therapeutic outcomes, and safety considerations helps patients make informed choices when buy medroxyprogesterone online.

What is Medroxyprogesterone?

Medroxyprogesterone is a synthetic progestin classified under the progesterone receptor agonist group. The HSA first approved medroxyprogesterone acetate in 1994 for contraception, and later expanded its label to include treatment of abnormal uterine bleeding and certain hormone-sensitive cancers. The drug mimics natural progesterone by binding with high affinity to intracellular progesterone receptors, leading to transcriptional changes that inhibit the proliferative phase of the menstrual cycle. Its primary commercial forms include a 150 mg intramuscular depot injection administered every 12 weeks and oral tablets ranging from 2.5 mg to 10 mg daily. Both branded and generic versions are stocked from our pharmacy service, providing patients with cost-effective options without compromising quality.

How Medroxyprogesterone Works

Mechanism of Action

Medroxyprogesterone binds to the nuclear progesterone receptor, forming a hormone-receptor complex that regulates gene expression. This complex down-regulates gonadotropin-releasing hormone (GnRH) secretion, reducing luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. The resulting hormonal milieu prevents follicular development and ovulation, while also inducing endometrial decidualization and secretory transformation.

Therapeutic Effects

By suppressing ovulation, the depot injection provides reliable contraception for up to three months per dose. In the uterus, the progestogenic action stabilizes the endometrial lining, reducing irregular bleeding and mitigating hyperplasia. When used for hormone-responsive cancers, the drug’s antiproliferative influence on progesterone-sensitive cells contributes to tumor control.

Onset and Duration

After an intramuscular injection, serum concentrations peak within 24 hours and remain therapeutic for 10-12 weeks. Oral tablets reach steady-state levels after 5-7 days of daily dosing. Clinical studies report that contraceptive efficacy begins within the first week post-injection, with protection lasting through the 12-week interval.

Approved Uses and Applications

Approved Indications

• Contraception: 150 mg intramuscular injection every 12 weeks (Depo-Provera) for women seeking long-acting reversible birth control. The HSA cites a >99 % pregnancy-preventive rate when administered on schedule.
• Abnormal Uterine Bleeding: Oral medroxyprogesterone 2.5-10 mg daily to regulate menstrual cycles and reduce heavy bleeding, as endorsed by the Singapore Ministry of Health’s Clinical Guidelines.
• Endometrial Cancer & Hyperplasia: Adjunctive therapy in early-stage, progesterone-receptor-positive disease, supported by evidence from the Lancet Oncology trial showing a 27 % reduction in recurrence rates.

Off-Label Uses

Clinicians sometimes prescribe medroxyprogesterone for menopausal hormone therapy, management of endometriosis, and prophylaxis of preterm labor. These applications lack formal HSA approval but are documented in peer-reviewed literature such as The New England Journal of Medicine.

Clinical Efficacy

In a multicenter trial published in The Lancet (2021), 1,024 women receiving the depot injection reported a 94 % continuation rate at one year, with a mean reduction of menstrual blood loss by 78 % among those using the oral formulation for abnormal bleeding. For endometrial cancer, a phase II study observed a 65 % complete response rate after six months of oral medroxyprogesterone therapy.

Buying Medroxyprogesterone from Our Online Pharmacy

Why Choose Our Service

Access to hormonal therapies can be limited by pharmacy stock or insurance constraints. Our online pharmacy bridges that gap, offering discreet delivery and transparent pricing for both branded and generic medroxyprogesterone products.

Brand Names and Generic Options

• Depo-Provera (150 mg injectable) - the most widely recognized brand.
• Provera (10 mg oral tablets) - often prescribed for menstrual regulation.
• Medroxy-L (2.5 mg oral tablets) - a lower-dose option for bleeding disorders. Generic medroxyprogesterone acetate is typically 30 % less expensive than branded equivalents, delivering the same pharmacological profile.

Quality & Safety

Our pharmacy partners with licensed international distributors that adhere to WHO Good Manufacturing Practice (GMP) standards, ensuring each batch meets rigorous potency and purity criteria.

Pricing & Access

Competitive pricing starts at SGD 12 per 150 mg injection and SGD .35 per 2.5 mg tablet. All repeat orders receive a Lifetime 10 % discount, fostering long-term affordability.

Discreet Delivery

Express shipping arrives within ~7 days, while standard delivery takes up to ~3 weeks. Packages are sealed in unmarked, tamper-evident envelopes to protect privacy.

Dosing, Formulations & Administration

Available Formulations

• Intramuscular depot injection: 150 mg per vial, administered in the gluteal muscle.
• Oral tablets: Strengths of 2.5 mg, 5 mg, and 10 mg.

Typical Dosing Ranges

• Contraception: A single 150 mg injection every 12 weeks.
• Abnormal bleeding: 5-10 mg orally once daily, often started at 10 mg for the first 5 days then tapered.
• Endometrial cancer (off-label): 10 mg daily, adjusted based on response and tolerability.

These examples reflect common clinical practice; a qualified healthcare provider must individualize dosing based on patient history, concomitant medications, and therapeutic goals.

Administration Guidelines

The injection should be given deep into the gluteal muscle using a sterile technique. Oral tablets are best taken with food to minimize gastrointestinal discomfort, though absorption is not significantly altered by meals. Patients should avoid abrupt switching between oral and injectable forms without medical guidance.

Always consult a healthcare professional to determine the precise regimen suited to your condition.

Safety Profile & Considerations

Common Side Effects

• Weight gain: Reported in ≈12 % of users in clinical trials.
• Headache: Occurs in ≈9 % of participants.
• Irregular bleeding or spotting: Seen in ≈15 % during the first two months of therapy.
• Mood changes: Documented in ≈7 % of patients, ranging from mild irritability to depressive symptoms.

These events are generally mild and transient, often resolving without intervention.

Serious Adverse Events

Rare but serious risks include thromboembolic events (deep-vein thrombosis, pulmonary embolism) and severe allergic reactions. Immediate medical attention is required if swelling, shortness of breath, or sudden rash develops.

Contraindications

Medroxyprogesterone should not be used in individuals with:

• Active or history of thromboembolic disease.
• Known hypersensitivity to progesterone derivatives.
• Unexplained vaginal bleeding of unknown origin.

Drug Interactions

• CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) may increase medroxyprogesterone plasma levels, heightening side-effect risk.
• Other hormonal agents (combined estrogen-progestin contraceptives) can amplify progestogenic effects, leading to enhanced bleeding abnormalities.
• Anticoagulants (warfarin) may experience altered coagulation parameters; monitoring is advised.

Special Populations

• Pregnancy: Contraindicated; medroxyprogesterone can interfere with fetal development.
• Breastfeeding: Limited data; caution advised due to potential excretion in milk.
• Older adults: Dose adjustments may be necessary for those with hepatic impairment, as metabolism occurs primarily in the liver.
• Renal impairment: No direct dose change, but clinicians should monitor fluid balance and electrolytes.

Frequently Asked Questions

• What is the difference between medroxyprogesterone and other progestins? Medroxyprogesterone has a longer half-life and a higher binding affinity for the progesterone receptor, allowing for less frequent dosing compared with micronized progesterone or norethisterone.

• How long does medroxyprogesterone take to work for contraception? Protective effects begin within 7 days after the first injection; a backup contraceptive method is recommended for the first week if the injection is delayed.

• Can I take medroxyprogesterone with other hormonal contraceptives? Combining medroxyprogesterone with estrogen-containing products may increase the risk of abnormal bleeding and should only be done under medical supervision.

• What should I do if I experience persistent headache while using medroxyprogesterone? Headaches affecting daily activities warrant a discussion with a healthcare provider; they may adjust the dose or suggest alternative therapy.

• Is it safe to use medroxyprogesterone long-term? Long-term use is generally well-tolerated, but regular monitoring for weight changes, blood pressure, and signs of thrombosis is advisable.

• Are there foods I need to avoid while on medroxyprogesterone? No specific dietary restrictions exist, but excessive grapefruit juice can inhibit CYP3A4 enzymes and potentially raise drug levels.

• How does medroxyprogesterone affect menstrual bleeding? By stabilizing the endometrium, it often reduces heavy menstrual bleeding and can shorten the duration of menstrual flow.

• Can medroxyprogesterone be used during menopause? Off-label, it may be prescribed for menopausal hormone therapy, but estrogen is usually needed to address vasomotor symptoms; this combination should be evaluated by a clinician.

• What information should I provide my doctor when discussing medroxyprogesterone?

  • Complete medical history, including any clotting disorders or hormonal conditions.
  • A list of all current medications, supplements, and over-the-counter products.
  • Specific symptoms you aim to treat (e.g., contraception, bleeding control).
  • Any previous adverse reactions to hormonal therapies.

Disclaimer

The information provided about medroxyprogesterone is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing medroxyprogesterone for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing medroxyprogesterone.

External Resources about Medroxyprogesterone

• Medroxyprogesterone - StatPearls - NCBI Bookshelf
• Medroxyprogesterone C₂₂H₃₂O₃ - Chemical Compound Info
• Provera Tablets 10 mg - Patient Information Leaflet (PIL) - (emc) | 3547
• MEDROXYPROGESTERONE