Buy Cycrin
Cycrin
Cycrin Properties
About Cycrin
Cycrin (medroxyprogesterone) is a synthetic progestin that physicians prescribe for several conditions that affect women, including certain hormone-dependent cancers and disorders of the menstrual cycle. The active ingredient, medroxyprogesterone acetate, mimics the natural hormone progesterone and thereby influences the growth of hormone-sensitive tissues. In Singapore the medication is available as oral tablets in 5 mg and 10 mg strengths, and it must be taken under medical supervision.
What is Cycrin?
Cycrin is the trade name for the generic compound medroxyprogesterone acetate. It belongs to the class of progestogenic agents, a group of synthetic steroids that bind to progesterone receptors throughout the body. The product has been marketed in many countries for decades, and its safety profile has been shaped by extensive clinical experience. While the exact corporate origin of the Cycrin brand varies by market, the formulation contains the same active molecule found in other well-known preparations such as Depo-Provera and Provera. Because the active ingredient is identical, the therapeutic effects of Cycrin are considered bio-equivalent to those of other medroxyprogesterone products.
In Singapore the medication is classified as prescription-only, reflecting the need for physician oversight when it is used for hormonal modulation or cancer-related protocols.
How Cycrin Works
When Cycrin is swallowed, the tablet dissolves in the gastrointestinal tract and the medroxyprogesterone acetate is absorbed into the bloodstream. The drug exhibits high oral bioavailability; peak plasma concentrations are typically reached within 2-4 hours. It is extensively bound to plasma proteins (≈ 80 %) and is metabolised in the liver primarily by CYP3A4 enzymes. The elimination half-life ranges from 12 to 18 hours, which allows once-daily dosing for most indications.
At the cellular level, medroxyprogesterone binds to intracellular progesterone receptors (PR-A and PR-B). This binding triggers a conformational change that enables the receptor complex to act as a transcription factor, altering the expression of genes that regulate cell proliferation, differentiation, and apoptosis. In hormone-responsive tissues such as the endometrium or certain breast cancers, the activated receptor can suppress estrogen-driven growth signals, leading to reduced cellular proliferation and, in some cases, programmed cell death.
The drug’s anti-angiogenic properties-its ability to interfere with new blood-vessel formation-further contribute to its usefulness in cancer therapy. By limiting the blood supply to a tumour, medroxyprogesterone can hinder tumour expansion and enhance the effectiveness of adjunctive treatments.
Why Cycrin Is Used for Women’s-Health and Cancer Conditions
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Endometriosis and Adenomyosis - These disorders involve ectopic growth of endometrial tissue, driven in part by estrogen. Cycrin’s progestogenic action counteracts estrogen, stabilising the endometrium and reducing painful lesions. Clinical guidelines recommend cyclic or continuous progestin therapy as a first-line medical option when surgery is not immediately indicated.
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Premenstrual Syndrome (PMS) and Dysmenorrhea - By providing a steady progesterone-like signal, Cycrin dampens the abrupt hormonal fluctuations that trigger uterine contractions and mood changes. Studies have shown that regular progestin administration can lower the frequency of severe cramps and mitigate mood-related symptoms in a subset of patients.
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Hormone-Dependent Breast Cancer - In tumours that express progesterone receptors, medroxyprogesterone can inhibit estrogen-mediated proliferation. Phase II trials have demonstrated disease-stabilisation in a proportion of patients receiving low-dose progestin as part of a hormonal regimen, especially when combined with aromatase inhibitors.
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Endometrial Hyperplasia - Over-growth of the uterine lining poses a risk of progression to carcinoma. Cycrin induces decidualisation-a transformation of the lining into a less proliferative state-thereby lowering the risk of malignant conversion. Decision-analysis models support the use of progestins as a conservative alternative to hysterectomy in selected women.
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Cervical Cancer Adjunct - In certain low-grade cervical intra-epithelial neoplasia (CIN) lesions, progestins may promote squamous maturation and reduce viral load of high-risk HPV strains, offering a non-surgical pathway to regression.
Off-Label and Investigational Uses of Cycrin
Beyond its approved indications, clinicians sometimes employ medroxyprogesterone in experimental protocols. Small-scale studies have explored its role in:
- Management of refractory hot flashes in post-menopausal women, where low-dose progestin appears to attenuate vasomotor symptoms.
- Adjunctive therapy for metastatic prostate cancer, leveraging its anti-angiogenic effect; however, evidence remains preliminary.
These applications are not sanctioned by Singapore’s Health Sciences Authority. Off-label use should occur only under the supervision of a qualified healthcare professional who can monitor efficacy and safety closely.
Is Cycrin Right for You?
Cycrin is generally appropriate for adult women who require hormonal regulation or who have hormone-sensitive tumours that have expressed progesterone receptors. Patients with a history of thromboembolic disease, severe liver dysfunction, or known hypersensitivity to synthetic progestins are advised against its use. Because the drug interacts with the clotting cascade, clinicians often assess cardiovascular risk before initiating therapy.
In elderly patients or those with compromised hepatic metabolism, dose adjustments may be necessary to avoid accumulation. Women who are pregnant or attempting conception should discuss alternative strategies, as medroxyprogesterone can affect fetal development. Overall, suitability hinges on a thorough evaluation of the individual’s medical history, concomitant medications, and the specific therapeutic goal.
Taking Cycrin Effectively
- Timing - The tablet should be taken at the same time each day to maintain stable plasma levels. For cyclic regimens (e.g., 21 days on, 7 days off), patients are instructed to start the first tablet on the first day of menstruation.
- Food - Medroxyprogesterone’s absorption is not markedly altered by meals, allowing flexibility; however, a high-fat meal may modestly delay peak concentration, which is generally clinically irrelevant.
- Interaction Awareness - Concurrent use of strong CYP3A4 inducers (e.g., certain antiepileptics) can lower drug exposure, potentially reducing efficacy. Patients should inform their prescriber of all herbal supplements, especially St John’s Wort.
- Missed Dose - If a dose is forgotten, take it as soon as remembered unless the next scheduled dose is imminent; in that case, skip the missed tablet and continue with the regular schedule. Doubling the dose is not recommended.
- Adherence Strategies - Setting a daily alarm, using a pill-organiser, or linking intake to a routine activity (e.g., brushing teeth) improves compliance. For travel, carry a small contingency supply and keep the medication in its original labelled container.
Understanding Side Effects and How to Manage Them
Side effects arise because the synthetic hormone engages the same receptors as natural progesterone, influencing multiple organ systems. Commonly reported sensations include mild nausea, breast tenderness, and transient weight gain due to fluid retention. These typically resolve within the first few weeks as the body adapts.
If gastrointestinal upset becomes bothersome, taking the tablet with a light snack can temper the effect. For breast discomfort, a supportive bra and application of warm compresses may provide relief.
More serious adverse signals-such as sudden swelling of the legs, shortness of breath, severe abdominal pain, or visual disturbances-suggest possible thromboembolic events or hepatic complications. In such circumstances, immediate medical attention is warranted. Patients should also be alert to signs of adrenal insufficiency (e.g., profound fatigue, dizziness) if the drug is discontinued abruptly after long-term use; a gradual taper under physician guidance mitigates this risk.
Buying Cycrin from Our Online Pharmacy
Why Choose Our Service?
Our platform simplifies access to Cycrin for Singapore residents who may encounter limited stock or high retail prices at brick-and-mortar pharmacies. By sourcing directly from accredited overseas suppliers, we keep costs close to the manufacturing price while preserving product integrity.
Quality & Safety
We partner with licensed international pharmacies that operate under stringent regulatory frameworks recognized by the World Health Organization. Every batch undergoes verification for authenticity, potency, and proper packaging before it leaves the supplier’s facility.
Pricing & Access
Because Cycrin is offered as a generic-equivalent progestin, the price per tablet is substantially lower than many branded alternatives. In addition, we provide a 10 % discount on repeat orders, making long-term therapy more affordable for patients with chronic indications.
Discreet Delivery
Orders placed through our online pharmacy are shipped in unbranded, bubble-wrapped packages. Standard airmail usually arrives within three weeks, while express delivery can be completed in about seven days, both with full confidentiality.
Frequently Asked Questions
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How quickly can I expect symptom relief after starting Cycrin? For menstrual-related complaints, many women notice a reduction in pain or irregular bleeding within one to two menstrual cycles. In oncologic settings, therapeutic response is evaluated after several weeks of continuous dosing, often in conjunction with imaging studies.
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Can Cycrin be used as a form of birth control? While progestins are components of some contraceptive regimens, Cycrin is not approved for contraception in Singapore. Dedicated contraceptive products provide more reliable ovulation suppression and include dosing schedules specifically designed for that purpose.
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Is it safe to take Cycrin while on hormone replacement therapy (HRT)? Combining multiple progestogenic agents can increase the risk of side effects such as thrombosis. Physicians typically adjust the overall hormone dose or select a single agent to avoid overlap.
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What should I do if I experience breakthrough bleeding? Minor spotting is common during the initial weeks of therapy. Maintaining consistent tablet intake and allowing a full treatment cycle often resolves the issue. Persistent or heavy bleeding warrants a follow-up visit.
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Are there dietary restrictions while using Cycrin? No specific foods must be avoided, but excessive alcohol intake can strain liver metabolism, potentially altering drug levels. Moderation is advisable.
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How does Cycrin compare to other progestins like norethisterone? Medroxyprogesterone has a longer half-life and stronger affinity for the progesterone receptor, making it useful for once-daily dosing. Norethisterone, by contrast, is often prescribed for short-term cycle regulation.
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Can men take Cycrin for any condition? The medication is licensed only for female indications. Off-label use in men, such as for prostate cancer, remains experimental and should only occur within a clinical trial setting.
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What monitoring is required during treatment? Baseline liver function tests and periodic lipid panels are recommended, especially for long-term users. In cancer therapy, imaging and tumour marker assessments guide therapeutic decisions.
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Is a blood test needed before starting Cycrin? A complete blood count, liver enzymes, and assessment of coagulation status help identify contraindications and establish a safe baseline.
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Will I need a new prescription after a few months? Continuation depends on the underlying condition and treatment response. Regular clinical reviews allow the prescriber to confirm ongoing necessity and adjust dosage if required.
Glossary
- Progesterone Receptor (PR)
- A nuclear hormone receptor that, upon binding progesterone or synthetic analogues, regulates gene transcription influencing cell growth and differentiation.
- CYP3A4
- A key liver enzyme responsible for metabolising many drugs, including medroxyprogesterone; its activity can be altered by other medications or dietary substances.
- Anti-angiogenic
- Refers to a substance’s ability to inhibit the formation of new blood vessels, thereby restricting nutrient supply to tumours.
- Decidualisation
- The process by which endometrial stromal cells transform into specialized decidual cells under progesterone influence, reducing proliferative activity.
- Thromboembolism
- The formation of a blood clot that can travel through the circulation and potentially block a vessel, a known risk with certain hormonal therapies.
Disclaimer
The information provided about Cycrin is intended for general educational purposes only and does not substitute professional medical consultation. All therapeutic decisions, including those concerning off-label applications, should be made under the guidance of a qualified healthcare provider. Readers are presumed to be adults capable of making informed health choices. Our online pharmacy offers access to Cycrin for individuals who may experience limited availability through conventional pharmacies, lack insurance coverage, or seek cost-effective generic alternatives. Always discuss with your physician before initiating, altering, or discontinuing any medication.
