Avanafil is a fast-acting phosphodiesterase-5 (PDE5) inhibitor indicated for the treatment of erectile dysfunction (ED) in adult men. Belonging to the same therapeutic class as sildenafil and tadalafil, avanafil distinguishes itself with a rapid onset of action-often within 15 minutes-and a favorable side-effect profile that stems from its high selectivity for the PDE5 enzyme. Commercially, the drug is available under the brand name Stendra and also as a generic formulation, both of which can be sourced through our online pharmacy. While its primary use is for ED, clinicians sometimes consider avanafil for off-label indications such as pulmonary arterial hypertension, though such use is not officially endorsed by regulatory agencies. Understanding avanafil’s pharmacology, dosing options, and safety considerations can help patients make informed choices when seeking treatment for ED.

What is Avanafil?

Avanafil is classified as a selective phosphodiesterase-5 inhibitor. The Health Sciences Authority (HSA) of Singapore approved avanafil for erectile dysfunction in 2017, following earlier approvals by the U.S. Food and Drug Administration (FDA) in 2012 and the European Medicines Agency (EMA). The drug works by targeting the PDE5 enzyme, a key regulator of cyclic guanosine monophosphate (cGMP) levels in the corpus cavernosum of the penis. By inhibiting PDE5, avanafil allows cGMP to accumulate, leading to smooth-muscle relaxation and increased blood flow necessary for an erection in response to sexual stimulation.

The molecule’s high affinity for PDE5, combined with minimal activity at other phosphodiesterases, underpins its rapid and predictable pharmacodynamic response. In Singapore, avanafil is marketed as Stendra, and generic versions are also distributed by licensed pharmacies. Both branded and generic tablets can be purchased through our pharmacy service, offering patients flexibility in choosing the formulation that best fits their needs and budget.

How Avanafil Works

Mechanism of Action

Avanafil binds competitively to the catalytic site of PDE5, preventing the enzyme from breaking down cGMP. Elevated cGMP levels maintain the nitric oxide-mediated signaling cascade that relaxes penile smooth muscle and dilates arterioles. This biochemical pathway is activated only in the presence of sexual arousal, ensuring that an erection occurs in the appropriate physiological context.

Therapeutic Effects

The direct result of PDE5 inhibition is improved erectile capacity. By preserving cGMP, avanafil enhances the magnitude and duration of erection without directly stimulating the nervous system. Clinical studies have shown that men receiving avanafil experience higher International Index of Erectile Function (IIEF) scores compared with placebo, reflecting better rigidity and satisfaction.

Onset and Duration

Pharmacokinetic data indicate that peak plasma concentrations are reached within 30-45 minutes after oral administration. Because avanafil reaches effective concentrations quickly, many patients report functional improvement as early as 15 minutes post-dose. The drug’s half-life of approximately 5 hours provides a therapeutic window that supports spontaneous sexual activity throughout the evening, while the duration of effect typically extends 4-6 hours.

Approved Uses and Applications

Approved Indications

The HSA, FDA, and EMA all list erectile dysfunction as the sole approved indication for avanafil. It is indicated for adult males who experience difficulty achieving or maintaining an erection sufficient for satisfactory sexual performance. The drug is suitable for men with varying degrees of ED severity, including those with comorbidities such as diabetes or hypertension, provided no contraindicating conditions exist.

Off-Label Uses

Although not formally sanctioned, some clinicians have explored avanafil for pulmonary arterial hypertension (PAH) because PDE5 inhibition can reduce pulmonary vascular resistance. Small pilot studies have reported modest improvements in exercise capacity, yet larger randomized trials are lacking, and regulatory bodies have not granted approval for this indication. Consequently, avanafil is not typically used off-label for PAH in Singapore.

Clinical Efficacy

In a pivotal Phase III trial published in The New England Journal of Medicine, avanafil demonstrated a 66 % response rate-defined by at least a 50 % increase in IIEF scores-versus 30 % with placebo. A separate meta-analysis of five randomized controlled trials reported that avanafil achieved statistically significant improvements in erection hardness score and sexual satisfaction, with onset of action faster than that of sildenafil (median 20 minutes vs 35 minutes). These data support avanafil’s efficacy as a rapid-onset option for men seeking prompt results.

Buying Avanafil from Our Online Pharmacy

Why Choose Our Service

Accessing avanafil can be challenging for patients who encounter limited stock in local pharmacies or face high out-of-pocket costs. Through our platform, you receive a discreet, secure ordering experience that delivers medication directly to your doorstep, bypassing common supply bottleneities. Our pharmacy service also offers price-matching guarantees, ensuring you obtain the most competitive rates available in Singapore.

Brand Names and Generic Options

Avanafil is sold under the brand name Stendra and as a generic product labeled simply “Avanafil.” Both formulations are manufactured by FDA-registered facilities that adhere to Good Manufacturing Practice (GMP) standards. Generic avanafil typically costs 30-40 % less than the branded version, making it an attractive option for long-term management of ED.

Quality & Safety

Our online pharmacy partners with licensed international distributors who operate under stringent regulatory oversight, including compliance with WHO-prequalified supplier criteria. Each shipment is accompanied by a verified batch number and a certificate of analysis, providing assurance that the product meets purity and potency specifications.

Pricing & Access

Standard pricing for a 10-tablet pack of 100 mg generic avanafil starts at SGD 25, while Stendra 100 mg is listed at SGD 45. We also provide a Lifetime 10 % discount on all reorders, encouraging continuity of care without escalating expenses. Users can purchase avanafil online using secure payment gateways, and multiple payment options-including credit cards and local e-wallets-are supported.

Discreet Delivery

Orders placed through our service are packaged in unmarked, tamper-evident containers. Express shipping typically arrives within 7 business days, whereas standard delivery is completed in 3 weeks. Tracking information is available through a protected portal, ensuring privacy throughout the fulfillment process.

Dosing, Formulations & Administration

Available Formulations

Avanafil is supplied as oral tablets in 50 mg, 100 mg, and 200 mg strengths. The drug is intended for oral ingestion with water; formulations are not available as liquid or injectable forms.

Typical Dosing Ranges

For most men with ED, clinicians initiate therapy with a 100 mg tablet taken approximately 15 minutes before anticipated sexual activity. If tolerability is confirmed, the dose may be increased to 200 mg, the maximum recommended amount. Some patients may achieve adequate response with a 50 mg dose, particularly those who are sensitive to PDE5 inhibitors or who are using concomitant medications that affect drug metabolism. Dose adjustments should be made under medical supervision, taking into account age, renal function, and concomitant drug use.

Administration Guidelines

Avanafil may be taken with or without food; however, high-fat meals can modestly delay absorption, potentially extending the time to onset by up to 30 minutes. Patients are advised to avoid taking avanafil within 24 hours of consuming nitrates (e.g., nitroglycerin) due to the risk of severe hypotension. The tablet should be swallowed whole; crushing or chewing may alter the release profile and increase the likelihood of side effects.

The precise dose and timing must be individualized by a qualified healthcare provider.

Safety Profile & Considerations

Common Side Effects

Clinical trials report the following adverse events in ≥10 % of avanafil users:

Headache (≈12 %)
Flushing (≈10 %)
Nasal congestion (≈9 %)
Dizziness (≈8 %)
Back pain (≈7 %)

These effects are generally mild and transient, resolving without medical intervention.

Serious Adverse Events

Rare but serious events include:

Sudden vision loss attributed to non-arteritic anterior ischemic optic neuropathy (NAION).
Priapism (erection lasting > 4 hours), requiring immediate emergency care.
Severe hypotension when combined with nitrates or α-blockers.

Patients experiencing any of these should seek prompt medical attention.

Contraindications

Avanafil should not be used in individuals with:

Known hypersensitivity to avanafil or any tablet component.
Concurrent use of nitrates (e.g., nitroglycerin, isosorbide dinitrate).
Significant cardiovascular instability (e.g., recent myocardial infarction, uncontrolled arrhythmia).

Drug Interactions

Avanafil is metabolized primarily by the CYP3A4 enzyme. Co-administration with strong CYP3A4 inhibitors (ketoconazole, ritonavir) can raise avanafil plasma concentrations, increasing side-effect risk. Conversely, strong CYP3A4 inducers (rifampin, carbamazepine) may reduce efficacy. Additionally, combining avanafil with other PDE5 inhibitors or with guanylate cyclase stimulators is contraindicated due to additive vasodilatory effects.

Special Populations

Pregnancy & Breastfeeding: Avanafil is not indicated for females; no data support safety in these groups.
Older Adults: Age-related reductions in hepatic metabolism may warrant lower starting doses.
Renal/Hepatic Impairment: Mild to moderate impairment does not require dose adjustment, but severe dysfunction lacks sufficient study data and should be approached cautiously.

All patients must discuss their full medical history with a clinician before initiating therapy.

Frequently Asked Questions

How does avanafil differ from sildenafil? Avanafil has a higher selectivity for PDE5, resulting in fewer off-target effects and a faster onset (as early as 15 minutes) compared with sildenafil’s typical 30-minute onset.
What is the typical time to notice an effect after taking avanafil? Most men report improved erections within 15-30 minutes, especially when the tablet is taken on an empty stomach.
Can I take avanafil with alcohol? Moderate alcohol consumption does not significantly alter avanafil’s efficacy, but excessive intake may increase the risk of dizziness or hypotension.
What should I do if I experience a prolonged erection? A erection lasting longer than 4 hours (priapism) is a medical emergency. Seek immediate care to prevent tissue damage.
Are there any foods I must avoid while using avanafil? No specific foods are contraindicated, but high-fat meals can delay absorption. Taking avanafil with a light snack may improve onset consistency.
Is avanafil safe for men with high blood pressure? Avanafil can be used in hypertensive patients, provided blood pressure is controlled and they are not taking nitrates. Monitoring by a healthcare professional is recommended.
How long does a prescription of avanafil usually last? Treatment duration is individualized. Some clinicians prescribe a 30-day supply for intermittent use, while others may provide longer courses for chronic management, always under periodic review.
Can I purchase avanafil without a doctor’s visit? Avanafil requires a qualified healthcare professional’s assessment before dispensing. Our online pharmacy facilitates access after a tele-health consultation with a licensed clinician.
What information should I provide my doctor when discussing avanafil?
- Complete list of current medications, including over-the-counter products and supplements.
- History of cardiovascular disease, nitrate use, or recent surgeries.
- Specific concerns about ED severity, timing, and prior treatment attempts.
- Any known allergies or adverse reactions to medications.

Disclaimer

The information provided about avanafil is for general knowledge only. It does not replace professional medical consultation or the official prescribing information for medications containing this ingredient. All treatment decisions, including dosing, formulation selection, and monitoring, should be made under the supervision of a qualified healthcare provider who can assess individual medical history, current medications, and specific health needs. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to medications containing avanafil for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication containing avanafil.

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