Buy Stendra
Stendra
Stendra Properties
About Stendra
Generic Stendra (Avanafil) is a prescription-only oral medication used to treat erectile dysfunction in adult men. It contains the active ingredient avanafil, a phosphodiesterase-5 (PDE-5) inhibitor that improves blood flow to the penis during sexual stimulation. Approved by the Health Sciences Authority (HSA) of Singapore, Stendra is available in 50 mg, 100 mg and 200 mg tablets and is taken as needed prior to sexual activity. While its primary indication is erectile dysfunction, clinicians sometimes consider it for other sexual health concerns after evaluating the evidence and patient needs.
What is Generic Stendra (Avanafil)?
Generic Stendra (Avanafil) belongs to the class of PDE-5 inhibitors, which also includes sildenafil, tadalafil and vardenafil. The HSA approved avanafil in 2018 for use in Singapore, categorising it as a prescription drug that must be dispensed by a licensed pharmacist. The medication is marketed as a fast-acting option, with onset of action typically within 15 minutes and a duration of effect of up to six hours. It is manufactured under strict Good Manufacturing Practice (GMP) standards, and the generic version is required to meet bio-equivalence criteria set by the HSA, ensuring it delivers the same therapeutic exposure as the original branded product.
How Stendra Works
Avanafil inhibits the PDE-5 enzyme, which under normal circumstances degrades cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpora cavernosa. During sexual arousal, nitric oxide released from nerve endings stimulates the production of cGMP, causing smooth-muscle relaxation and increased arterial inflow. By blocking PDE-5, avanafil sustains higher cGMP levels, prolonging vasodilation and facilitating erection when sexual stimulation occurs.
Pharmacokinetically, avanafil reaches peak plasma concentration within 30-45 minutes after oral ingestion, which explains its rapid onset. It is metabolised primarily by CYP3A4 and, to a lesser extent, CYP2C9, with an elimination half-life of approximately 5 hours. Food has a modest effect on absorption; a high-fat meal may delay onset by up to 30 minutes but does not significantly change overall exposure.
Why Stendra Is Used for Sexual Health Conditions
- Erectile dysfunction (ED) - The primary indication. By enhancing the nitric-oxide/cGMP pathway, avanafil restores the physiological response needed for an erection. Clinical trials in men with mild-to-moderate ED showed successful erections in 78 % of those taking 100 mg, comparable to other PDE-5 inhibitors but with a quicker onset.
- First-line therapy - International guidelines (e.g., European Association of Urology) list PDE-5 inhibitors as the first choice for most cases of organic ED. Avanafil’s rapid action makes it attractive for patients who prefer spontaneity.
- Cost-effectiveness - The generic formulation provides the same bio-equivalence as the brand at a lower price point, making it a financially sensible option for many patients in Singapore.
- Safety profile - Compared with older PDE-5 inhibitors, avanafil has a slightly lower incidence of visual disturbances and systemic hypotension, which can be relevant for patients on antihypertensive therapy.
Off-Label and Investigational Uses of Stendra
Evidence from small RCTs suggests avanafil may improve pulmonary arterial hypertension by reducing pulmonary vascular resistance, but it is not approved for this indication in Singapore. A handful of studies have explored its use in female sexual interest/arousal disorder, yet results are inconsistent and safety data remain limited.
Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Stendra Right for You?
Stendra is suitable for men with diagnosed erectile dysfunction who can tolerate oral medications and have no contraindications such as concurrent nitrate therapy or severe uncontrolled cardiovascular disease. It can be used by older adults, provided renal and hepatic function are assessed; dose adjustments are rarely needed because avanafil is not heavily dependent on renal clearance. Pregnant or breastfeeding women are not candidates, as the drug is intended for male sexual health. Patients with a history of priapism should seek specialist advice before initiating therapy.
Taking Stendra Effectively
- Timing - Take the tablet with water at least 15 minutes before planned sexual activity; for the 50 mg dose, a 30-minute window may be preferable.
- Food - A light meal will not impair efficacy; a very fatty meal may delay onset, so consider timing if spontaneity is essential.
- Missed dose - Since Stendra is taken as needed, there is no “daily” dosing schedule. If a dose is forgotten, simply skip it; do not take an extra tablet later.
- Travel - Keep tablets in their original packaging with a copy of the prescription; Singapore’s HSA allows a 30-day supply for personal use when traveling abroad.
- Alcohol - Moderate consumption does not alter the drug’s effect, but excessive intake can impair erection irrespective of medication.
Understanding Side Effects and How to Manage Them
Common adverse events are related to the drug’s vasodilatory action: headache, flushing, nasal congestion and mild dizziness. These arise because PDE-5 inhibition can also affect vascular beds outside the penis.
- Headache - Usually mild; stay hydrated and consider over-the-counter acetaminophen if needed.
- Flushing - May be reduced by avoiding hot showers or spicy foods shortly after dosing.
- Nasal congestion - A saline nasal spray can provide relief.
Serious side effects are rare but require immediate medical attention: sudden vision loss, hearing impairment or a painful, prolonged erection (priapism) lasting more than four hours. If any of these occur, seek emergency care.
Buying Stendra from Our Online Pharmacy
Why Choose Our Service?
Our online pharmacy offers a discreet, convenient way to obtain Stendida, especially for patients who face supply constraints at local pharmacies or who prefer privacy.
Quality & Safety
We partner with licensed international pharmacies that adhere to WHO-certified Good Manufacturing Practices, ensuring each tablet meets the stringent quality standards mandated by Singapore’s Health Sciences Authority.
Pricing & Access
Generic Stendra is priced competitively, delivering up to 40 % savings compared with the branded version. We also provide a Lifetime 10 % discount on all reorders, making long-term management more affordable.
Discreet Delivery
Orders are packaged in unmarked envelopes and shipped via a secure courier. Express delivery arrives in approximately 7 days, while standard shipping takes up to three weeks, both with tracking available.
Frequently Asked Questions
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What should I do if I experience a headache after taking Stendra? Headaches are common and usually mild. Hydration and a simple analgesic such as acetaminophen often provide relief. If headaches persist or are severe, consult your physician.
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Can I take Stendra with blood pressure medication? Avanafil can be combined safely with most antihypertensives, but caution is advised when using nitrates or certain alpha-blockers, as the combination may cause dangerous drops in blood pressure.
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How does Stendra differ from other PDE-5 inhibitors? Its primary distinction is a faster onset of action-typically within 15 minutes-allowing greater spontaneity. The side-effect profile is also slightly milder in terms of visual disturbances.
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Is Stendra effective for men with diabetes-related erectile dysfunction? Yes. Clinical data indicate comparable efficacy in diabetic populations, though response rates may be modestly lower than in non-diabetic men. Optimising glycaemic control can improve outcomes.
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Can I use Stendra if I have mild liver disease? Avanafil is metabolised primarily by the liver, but dose reduction is not routinely required for mild hepatic impairment. Severe liver disease warrants specialist evaluation before use.
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What is the recommended dosing schedule for the 200 mg tablet? The 200 mg dose is reserved for men who have not achieved satisfactory erections with lower doses. It should be taken no more than once daily, with at least 24 hours between doses.
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Will Stendra affect my fertility? PDE-5 inhibitors do not alter sperm production or hormonal balance. They act locally on penile vasculature and have no known impact on fertility.
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Is it safe to use Stendra recreationally without a medical diagnosis? Use without a proper medical assessment increases the risk of adverse events and may mask underlying health conditions. Always obtain a prescription after appropriate clinical evaluation.
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How long can I safely use Stendra? Long-term safety data up to several years show no cumulative toxicity. Ongoing use should be reviewed periodically by a healthcare professional to assess efficacy and tolerability.
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Can Stendra be used in combination with other sexual enhancement products? Combining multiple PDE-5 inhibitors or using it with unregulated “herbal” supplements can increase the risk of hypotension and other side effects. Discuss any additional products with your doctor.
Glossary
- Phosphodiesterase-5 (PDE-5) inhibitor
- A class of drugs that block the PDE-5 enzyme, preserving cGMP levels and promoting smooth-muscle relaxation in the penis.
- cGMP (cyclic guanosine monophosphate)
- A secondary messenger that mediates nitric-oxide-induced vasodilation, essential for erection physiology.
- Bio-equivalence
- Demonstrated similarity in the rate and extent of absorption between a generic product and its reference brand, ensuring comparable therapeutic effect.
Disclaimer
The information provided about Stendra is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Stendra for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
