Buy Acticin
Acticin
Acticin Properties
About Acticin
Acticin (permethrin 5 % cream) is a topical preparation that health-care professionals prescribe for the treatment of scabies and certain other parasitic skin infestations. Belonging to the class of synthetic pyrethroids, it works by disrupting the nervous system of mites and lice, leading to rapid paralysis and death of the parasites. In Singapore, Acticin is supplied in a 30 g tube, intended for single-application therapy on the affected skin areas.
What is Acticin?
Acticin is a brand-name, cream-form medication that contains the active ingredient permethrin, a synthetic analogue of the naturally occurring insecticide pyrethrin. The product is regulated as a prescription-only medicine in Singapore and is packaged in 30 g tubes, each providing enough cream for a full-body application in most adult patients. Although several manufacturers produce permethrin cream worldwide, Acticin is marketed locally without an internationally recognised parent company, which means that generic alternatives containing the same 5 % permethrin concentration are typically available at lower cost. The formulation is designed for topical use, allowing the active compound to penetrate the stratum corneum where the ectoparasites reside.
How Acticin Works
Permethrin belongs to the synthetic pyrethroid group, which exerts its effect by binding to voltage-gated sodium channels in the membranes of neuronal cells. Under normal conditions, these channels open briefly in response to an electrical impulse and then close, enabling the neuron to reset. Permethrin prolongs the opening of these channels, causing a sustained influx of sodium ions. The resulting depolarisation leads to repetitive nerve firing, loss of coordinated muscle activity, and ultimately paralysis of the parasite.
After topical application, the cream releases permethrin onto the surface of the skin. The compound is lipophilic, facilitating its diffusion through the outer epidermal layers. Systemic absorption is minimal; pharmacokinetic studies indicate that less than 2 % of the applied dose reaches the bloodstream, where it is rapidly metabolised by hepatic esterases to inactive metabolites eliminated in the urine. Onset of action is observed within a few hours, while the clinical resolution of scabies lesions typically becomes evident after 24-48 hours. The prolonged channel-blocking effect explains why a single full-body application is sufficient for most infestations.
Why Acticin is Used for Skin Infection Treatment
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Scabies - The mite Sarcoptes scabiei burrows within the epidermis, laying eggs that trigger intense pruritus. Permethrin’s neuronal toxicity eliminates both adult mites and newly hatched forms, breaking the life cycle. Clinical trials comparing 5 % permethrin cream with alternative treatments consistently show cure rates above 90 % after a single application, underpinning its recommendation in Singapore’s national guidelines for scabies management.
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Pediculosis capitis (head lice) - Lice attach to hair shafts and feed on blood, causing itching and infection. Although Acticin is formulated for skin, the same 5 % concentration is effective when applied to the scalp, as demonstrated in studies where eradication rates exceeded 95 % after a single 10-minute exposure. The drug’s rapid knock-down of the lice nervous system accounts for its high efficacy.
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Papular urticaria secondary to insect bites - In some patients, repeated bites from fleas or bed bugs trigger hypersensitivity reactions. Permethrin, when applied to the bite sites, can reduce mite presence and dampen the inflammatory response, leading to faster resolution of papules. While not a first-line indication, dermatologists sometimes incorporate it as an adjunctive measure.
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Cutaneous larva migrans (creeping eruption) - This condition results from hookworm larvae penetrating the skin. A single dose of permethrin cream applied to the lesion can halt larval migration, providing symptomatic relief within a day. The drug’s ability to target invertebrate neurocircuitry explains why it works beyond arthropod infestations.
These applications align with the drug’s mechanism: targeting the sodium channels unique to arthropods while sparing human neurons due to differential channel subtypes and lower systemic exposure.
Off-Label and Investigational Uses of Acticin
Beyond the approved indications, permethrin cream has been explored for several off-label purposes:
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Pre-exposure prophylaxis for scabies in outbreak settings - Some public-health programs have administered a single prophylactic application to close contacts of confirmed cases, aiming to curb transmission. Observational data suggest reduced secondary infection rates, though controlled trials are lacking. Off-label use only under qualified healthcare provider supervision.
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Treatment of demodex-associated rosacea - Demodex mites can exacerbate inflammatory facial eruptions. Small pilot studies report improvement after applying permethrin cream twice weekly for four weeks. Evidence remains preliminary, and the approach should be reserved for refractory cases under specialist guidance.
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Management of scabies in immunocompromised patients - Severe crusted scabies may require repeat applications of permethrin combined with adjunctive oral ivermectin. While not an official indication, case series document successful outcomes when the cream is used more than once. Such regimens must be orchestrated by an experienced clinician.
Is Acticin Right for You?
Acticin is primarily indicated for adults with confirmed scabies or head-lice infestations. Ideal candidates are individuals without known hypersensitivity to permethrin or other pyrethroids, and who can adhere to the recommended single-application protocol. Patients with extensive skin barrier disruption (e.g., severe eczema or widespread dermatitis) may experience increased absorption, warranting cautious use or alternative therapy.
As noted above, certain patients should avoid Acticin: those with a documented allergy to permethrin, other pyrethroids, or the cream’s excipients. Pregnant or breastfeeding women generally receive the medication only when the potential benefit outweighs theoretical risks; limited data suggest minimal systemic exposure, yet a risk-benefit discussion with a health professional is essential. Elderly patients often tolerate permethrin well, but clinicians may monitor for skin irritation more closely due to thinner epidermal layers.
Individuals with neurological disorders such as epilepsy do not have a contraindication, as the topical route limits central nervous system exposure. However, patients taking medications that inhibit hepatic esterases could theoretically experience higher systemic levels, though clinical relevance is low.
Taking Acticin Effectively
A successful treatment hinges on proper application technique rather than the dosage per se. The 30 g tube typically contains enough cream to cover the entire body from the neck down, and in cases of head lice, a smaller amount is sufficient for the scalp.
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Preparation - Bathe and gently towel-dry the skin, leaving it slightly damp; moisture enhances skin penetration. Avoid using heavy moisturisers before application, as they may create a barrier.
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Application - Using clean gloves or a disposable applicator, spread a thin, even layer of cream over all affected areas, extending to the wrists and ankles. For scabies, treat the entire body, including under nails and interdigital spaces, because mites can reside in these hidden niches.
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Timing - Leave the cream on for 8-12 hours (commonly overnight). The drug requires sufficient contact time to reach mites embedded deep within the stratum corneum. Washing off the cream before this interval reduces efficacy.
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Removal - After the prescribed exposure, wash the skin thoroughly with mild soap and water. Rinse nails and scalp thoroughly to eliminate residual product.
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Avoidance of re-exposure - Wash clothing, bedding, and towels in hot water (≥60 °C) and dry them on high heat. Items that cannot be laundered should be sealed in plastic bags for at least 72 hours, as permethrin loses potency once removed from the skin.
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Adherence tips - Set a reminder on your phone to apply the cream before bedtime and another alarm for the wash-off time. A simple checklist placed on the bathroom mirror can prevent missed steps.
If treatment fails to resolve symptoms after 2 weeks, contact a health-care provider; persistence may indicate crusted scabies or secondary bacterial infection requiring additional therapy.
Understanding Side Effects and How to Manage Them
Topical permethrin is generally well tolerated, yet some patients local reactions linked to the drug’s irritant properties or the cream’s inactive ingredients.
Why reactions occur: Permethrin can cause transient disruption of the skin’s barrier function, leading to sensations of burning, itching, or stinging. In rare cases, an allergic dermatitis develops when the immune system recognises the compound or a preservative as foreign.
Managing mild irritation: Applying a fragrance-free, hypoallergenic moisturiser after washing off the cream can soothe dryness. Over-the-counter antihistamine tablets (e.g., cetirizine) taken once daily may reduce itching if it persists beyond 24 hours.
Warning signs: Persistent redness spreading beyond the treated area, swelling, blister formation, or systemic symptoms such as fever, dizziness, or shortness of breath suggest a more severe reaction. These manifestations require immediate medical evaluation-call emergency services if airway compromise is suspected.
When to seek help: If you notice new rash patterns, severe pain, or signs of secondary infection (pus, increasing warmth, foul odour), contact your clinician promptly. Early intervention prevents complications such as bacterial cellulitis.
Buying Acticin from Our Online Pharmacy
Why Choose Our Service?
Our platform streamlines access to Acticin, offering a discreet, cost-effective alternative for patients who face limited pharmacy stock or high retail prices. With a single click, you can initiate an order that arrives at your door without the need for multiple in-person visits.
Quality & Safety
We partner exclusively with licensed international pharmacies that operate under stringent regulatory frameworks recognised by health authorities worldwide. Each shipment undergoes verification for authenticity, ensuring the cream matches the 5 % permethrin specification and is stored according to manufacturer guidelines.
Pricing & Access
Because Acticin is a prescription medication, many local outlets charge a premium. Through our service, you receive the 30 g tube at a price close to the wholesale cost, translating into meaningful savings. Should you prefer a generic alternative, we also stock comparable 5 % permethrin creams from reputable manufacturers, allowing you to choose the option that best fits your budget.
Discreet Delivery
All orders are packaged in unmarked, bubble-wrapped envelopes to protect the product and safeguard your privacy. Standard delivery typically arrives within seven business days, while economy airmail may take up to four weeks, depending on customs processing. Tracking information is provided at each stage, so you can monitor progress in real time.
Frequently Asked Questions
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How soon after application should I notice relief from itching? Many patients experience a marked reduction in pruritus within 24 hours, as the mites are rapidly immobilised. Complete resolution of the rash may take several days, especially if secondary inflammation is present.
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Can I use Acticin on children? The cream is approved for use in children older than two months for scabies. For infants, a lower-dose formulation (1 %) is recommended; consult your pediatrician before treating younger patients.
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Is it safe to wash my hands immediately after applying the cream? Hands should be washed after the medication has been spread onto the intended skin areas. Rinsing prematurely can diminish the amount that reaches the parasites, potentially compromising efficacy.
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Do I need to repeat the treatment? A single full-body application cures the majority of scabies cases. However, in household outbreaks, a second application 7-10 days later may be advised to eradicate newly hatched mites that survived the first dose.
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Will Acticin affect my pets? Permethrin is toxic to cats and certain dog breeds. Keep the treated area away from pets until the cream is fully washed off and the skin is dry to avoid accidental transfer.
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Can I apply other skin products after using Acticin? Wait at least 24 hours after the wash-off before applying lotions, ointments, or medicated creams, unless directed otherwise by your health-care provider.
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How should I store the cream? Store at room temperature, away from direct sunlight and moisture. Do not refrigerate, as extreme temperatures can alter the formulation’s consistency.
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What if the medication expires before I use it? Expired cream may lose potency, reducing its ability to kill mites. If the expiry date has passed, obtain a fresh tube rather than extending the shelf-life.
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Is there any interaction with other topical medicines? Applying other medicated creams (e.g., corticosteroids) on the same area within 24 hours may dilute permethrin’s concentration. Stagger applications, using Acticin first and allowing the skin to dry before applying other products.
Glossary
- Synthetic pyrethroid
- A man-made compound modelled after natural pyrethrins, designed to target the nervous systems of insects and arachnids exhibiting low toxicity to mammals.
- Voltage-gated sodium channel
- A protein pore in neuronal membranes that opens in response to changes in electrical potential, allowing sodium ions to enter the cell and propagate nerve impulses.
- Cutaneous larva migrans
- A skin condition caused by the accidental penetration of animal hookworm larvae, resulting in serpiginous, itchy tracks as the larvae migrate beneath the epidermis.
- Hypersensitivity dermatitis
- An immune-mediated skin reaction that manifests as redness, swelling, and itching following exposure to an allergen or irritant.
Disclaimer
The information provided about Acticin is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Acticin for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
