Buy Eldepryl
Eldepryl
Eldepryl Properties
About Eldepryl
Eldepryl (selegiline) is a monoamine oxidase-B (MAO-B) inhibitor prescribed to help manage the motor symptoms of Parkinson’s disease. By selectively blocking the breakdown of dopamine in the brain, it modestly raises dopamine levels, which can smooth the “on-off” fluctuations that many patients experience. In Singapore, Eldepryl is available only with a prescription and is typically added to levodopa therapy or used as an early-stage adjunct. While its primary indication is Parkinson’s disease, clinicians sometimes consider it for certain depressive disorders, though such use remains off-label and must be supervised by a qualified healthcare provider.
What is Eldepryl?
Eldepryl is the brand formulation of the active ingredient selegiline, a selective MAO-B inhibitor. First approved in the United States in 1989, it has been marketed worldwide by Eli Lilly. In Singapore, the medication is classified as a prescription-only product and is listed under the therapeutic class “Antiparkinson agents.” Its availability is limited to pharmacies that dispense prescription medicines, and it is not sold over the counter.
How Eldepryl Works
Selegiline binds irreversibly to the MAO-B enzyme, preventing the enzymatic degradation of dopamine, phenylethylamine, and certain trace amines. By preserving dopamine in the striatum, the drug reduces the motor deficits caused by dopaminergic neuron loss in Parkinson’s disease. The inhibition is dose-dependent: low doses (≤10 mg/day) preferentially target MAO-B, while higher doses begin to affect MAO-A, raising the risk of hypertensive crises with tyramine-rich foods.
Pharmacokinetically, Eldepryl is well absorbed from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours after oral ingestion. It undergoes extensive hepatic metabolism via CYP2B6 and CYP2C19 to produce the active metabolite L-desmethylselegiline, which also contributes to MAO-B inhibition. The elimination half-life of the parent drug is approximately 1.5 hours, but the functional enzyme inhibition persists for up to two weeks because the binding is irreversible.
Why Eldepryl Is Used for Parkinson’s Disease
- Enhances dopaminergic tone: By sparing dopamine, it complements levodopa, allowing lower levodopa doses and reducing motor complications such as dyskinesia.
- Delays disease progression: Clinical trials have shown that early adjunctive use can modestly delay the need for levodopa initiation.
- Improves “off” periods: Patients report fewer and shorter “off” episodes when Eldepryl is added to a stable levodopa regimen.
- Guideline positioning: Both the American Academy of Neurology and the European Medicines Agency list MAO-B inhibitors as a recommended adjunct for patients with early motor fluctuations.
- Cost-effective alternative: Compared with newer dopamine agonists, Eldepryl often presents a lower acquisition cost while delivering comparable symptom control in selected patients.
Off-Label and Investigational Uses of Eldepryl
Evidence from randomized controlled trials suggests that selegiline may have antidepressant properties, particularly in treatment-resistant major depressive disorder. Small-scale studies have reported improvement in mood scores when used at doses that partially inhibit MAO-A. However, this indication is not approved by Singapore’s Health Sciences Authority, and the risk of hypertensive reactions with dietary tyramine increases at higher doses.
Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Eldepryl Right for You?
Eldepryl is most appropriate for patients who are already on levodopa but experience motor fluctuations, or for those in the early stages of Parkinson’s disease who wish to postpone levodopa initiation. It is generally well tolerated in adults over 50, but clinicians exercise caution in patients with a history of severe hepatic impairment, as metabolism may be altered. Pregnant or breastfeeding individuals are advised against use because safety data are insufficient. Renal dysfunction does not significantly affect clearance, yet dose adjustments are rarely required.
Taking Eldepryl Effectively
- Timing: The tablet should be taken once daily, preferably in the morning with a glass of water.
- Food interactions: A light breakfast is acceptable; avoid high-tyramine foods (aged cheeses, cured meats, soy sauce) when doses exceed 10 mg/day.
- Missed dose: If a dose is missed within 12 hours, take it as soon as remembered; otherwise skip and resume the regular schedule-do not double-dose.
- Travel tips: Carry a copy of the prescription and a medication list; keep the tablet in its original packaging to ease customs clearance.
Understanding Side Effects and How to Manage Them
Common side effects such as nausea, dry mouth, and mild insomnia stem from increased central catecholamine activity. Taking the tablet with food can reduce gastrointestinal upset, while limiting caffeine intake may lessen insomnia. Orthostatic hypotension, though less frequent at low doses, can be mitigated by rising slowly from seated positions.
Serious adverse events-hypertensive crisis, severe headache, or hallucinations-warrant immediate medical attention. These reactions are often linked to inadvertent MAO-A inhibition or drug interactions (e.g., selective serotonin reuptake inhibitors). Prompt discontinuation and evaluation by a physician are essential.
Buying Eldepryl from Our Online Pharmacy
Why Choose Our Service?
Our online pharmacy bridges the gap for patients who encounter limited stock or high out-of-pocket costs at local dispensaries. By sourcing Eldepryl through licensed international partners, we ensure authentic, FDA-approved medication while offering competitive pricing.
Quality & Safety
We work with suppliers that meet WHO Good Manufacturing Practice standards and are regularly audited for compliance. Every shipment includes a batch-specific certificate of analysis, guaranteeing potency and purity.
Pricing & Access
Eldepryl is offered at a price up to 30 % lower than many Singaporean retail pharmacies. For patients who require long-term therapy, we provide a Lifetime 10 % discount on all reorders, making sustained treatment more affordable.
Discreet Delivery
Orders are packaged in plain, tamper-evident containers. Express shipping delivers within ≈ 7 days, while standard service arrives in ≈ 3 weeks, both with full tracking.
Frequently Asked Questions
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What distinguishes Eldepryl from other MAO-B inhibitors? Eldepryl’s irreversible binding provides prolonged enzyme inhibition, allowing once-daily dosing. Compared with rasagiline, it has a longer half-life of functional inhibition, which can be advantageous for patients seeking stable plasma levels.
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Can I take Eldepryl with levodopa and a dopamine agonist simultaneously? Yes, many clinicians combine Eldepryl with levodopa and a dopamine agonist to fine-tune motor control. However, careful monitoring is required to avoid excessive dopaminergic stimulation, which may precipitate dyskinesia.
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Is dietary restriction necessary at the standard 5 mg dose? At 5 mg daily, MAO-B selectivity minimizes the risk of tyramine reactions, and most patients can follow a normal diet. Restrictions become important only when doses exceed 10 mg.
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How quickly will I notice improvement after starting Eldepryl? Symptomatic benefits often emerge within 2-4 weeks, though maximal effect may take up to 8 weeks as enzyme inhibition stabilizes.
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What should I do if I experience a hypertensive crisis? Seek emergency care immediately. Treatment typically involves intravenous nitroglycerin or phentolamine, followed by discontinuation of the MAO inhibitor.
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Are there any drug interactions I should be aware of? Concomitant use of serotonergic agents (SSRIs, SNRIs, tramadol) can increase the risk of serotonin syndrome. Always inform your prescriber of all medications, including over-the-counter supplements.
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Can Eldepryl be used in patients with mild cognitive impairment? Some studies suggest modest cognitive benefits due to increased dopaminergic tone, but evidence remains inconclusive. It should not replace approved treatments for dementia.
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Is it safe to switch from another brand of selegiline to Eldepryl? Because both products contain the same active ingredient, a direct switch is generally safe, provided the dosage remains equivalent and the new brand is sourced from a reputable supplier.
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What is the recommended storage condition? Store tablets at room temperature, away from moisture and direct sunlight. Do not refrigerate or freeze, as temperature extremes can affect tablet integrity.
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Will my insurance cover Eldepryl purchased online? Coverage varies by provider. Some insurers reimburse for prescription medications obtained through accredited online pharmacies, but you should verify eligibility before ordering.
Glossary
MAO-B (Monoamine Oxidase-B): An enzyme that degrades dopamine and other trace amines in the brain; inhibition increases dopamine availability. Irreversible binding: A type of enzyme inhibition where the inhibitor forms a permanent bond, requiring new enzyme synthesis for activity to return. Hypertensive crisis: A rapid, severe rise in blood pressure, often triggered by excess tyramine when MAO-A is inhibited. Pharmacokinetics: The study of how a drug is absorbed, distributed, metabolized, and excreted by the body. Serotonin syndrome: A potentially life-threatening condition caused by excessive serotonergic activity, presenting with agitation, hyperthermia, and neuromuscular abnormalities.
Disclaimer
The information provided about Eldepryl is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Eldepryl for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
