Buy Parlodel
Parlodel
Parlodel Properties
About Parlodel
Parlodel (bromocriptine) is a prescription dopamine agonist used primarily to manage Parkinson’s disease, hyperprolactinemia associated with pituitary disorders, and, in some cases, to improve glycemic control in type 2 diabetes. By stimulating dopamine receptors in the brain and pituitary gland, it helps restore dopamine balance, lower excess prolactin, and modulate glucose metabolism. In Singapore, this medication is available only with a doctor’s prescription and is regulated by the Health Sciences Authority. Patients often turn to Parlodel when standard therapies are insufficient or cause intolerable side effects, seeking a well-studied option that targets the underlying neuro-hormonal pathways.
What is Generic Parlodel (Bromocriptine)?
Generic Parlodel (Bromocriptine) belongs to the ergot-derived dopamine-agonist class. It received approval from the Singapore Health Sciences Authority for Parkinson’s disease and prolactin-secreting pituitary tumors in the early -s. The drug is supplied as a 2.5 mg oral tablet, taken once or twice daily depending on the indication. While the brand name Parlodel is recognized worldwide, the active ingredient bromocriptine is the same across all authorized formulations, ensuring consistent pharmacologic effect.
How Parlodel Works
Parlodel mimics dopamine by binding to D₂ receptors in the central nervous system. In the basal ganglia, this action restores dopaminergic tone, reducing motor rigidity, tremor, and bradykinesia in Parkinson’s disease. In the pituitary, dopamine inhibition of prolactin release curtails hyperprolactinemia, helping to normalize menstrual cycles, restore fertility, and shrink prolactin-producing adenomas. When used for type 2 diabetes, bromocriptine’s effect on hypothalamic pathways improves peripheral insulin sensitivity and reduces hepatic glucose output. After oral administration, peak plasma concentrations appear within 1-3 hours, and the drug’s half-life is roughly 8 hours, supporting once- or twice-daily dosing.
Why Parlodel Is Used for Parkinson’s Disease, Pituitary Disorders, and Type 2 Diabetes
- Parkinson’s disease - By replenishing dopaminergic activity, Parlodel alleviates motor symptoms and reduces the need for levodopa-induced dyskinesia. Clinical trials show a 20-30 % improvement in Unified Parkinson’s Disease Rating Scale scores when added to standard therapy.
- Hyperprolactinemia (pituitary disorders) - Dopamine agonism directly suppresses prolactin secretion, leading to rapid normalization of serum levels within weeks. Guidelines place dopamine agonists as first-line treatment for prolactin-secreting adenomas, often avoiding surgery.
- Type 2 diabetes (off-label) - Although the quick-release formulation Cycloset holds the official indication, conventional Parlodel tablets have demonstrated modest HbA1c reductions (≈.5 %) in small RCTs by enhancing insulin sensitivity.
These uses reflect the drug’s ability to target the same receptor pathways across distinct disease mechanisms.
Off-Label and Investigational Uses of Parlodel
Research has explored bromocriptine for conditions such as acromegaly, resistant hypertension, and certain psychiatric disorders, but evidence remains limited to early-phase studies. In Singapore, these applications are not approved by the Health Sciences Authority. Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Parlodel Right for You?
Parlodel suits adults who need dopamine-mediated control of motor symptoms, prolactin excess, or adjunctive glucose regulation. Ideal candidates have documented Parkinsonian features or elevated prolactin levels that have not responded to first-line agents. Caution is advised in patients with uncontrolled hypertension, severe hepatic impairment, or a history of fibrotic disorders. Pregnant or breastfeeding individuals should avoid bromocriptine unless the benefits clearly outweigh risks, as recommended by the local prescribing information.
Taking Parlodel Effectively
- Timing: For Parkinson’s disease, take Parlodel with breakfast to reduce nausea; for prolactin control, a morning dose aligns with circadian dopamine rhythms.
- Food interactions: High-fat meals can delay absorption; a light snack is acceptable.
- Missed dose: If a dose is forgotten within 12 hours, take it as soon as remembered; otherwise skip and resume the regular schedule-do not double-dose.
- Travel: Carry a small pill box and keep tablets at room temperature; avoid extreme heat or humidity during flights.
Understanding Side Effects and How to Manage Them
Parlodel’s most common side effects-nausea, headache, dizziness, and orthostatic hypotension-stem from its dopaminergic activity on the chemoreceptor trigger zone and vascular tone. Taking the medication with food, staying hydrated, and rising slowly from seated positions can mitigate these effects.
- Nausea: Start with a low dose and titrate upward; anti-emetics such as metoclopramide (used sparingly) may help.
- Dizziness/orthostatic drop: Monitor blood pressure, avoid alcohol, and consider splitting the dose if tolerated.
Serious adverse events, including pulmonary fibrosis, valvular heart disease, or severe hallucinations, require immediate medical evaluation. Promptly inform a healthcare professional if you experience shortness of breath, chest pain, or marked mood changes.
Buying Parlodel from Our Online Pharmacy
Why Choose Our Service?
Accessing Parlodel can be challenging in regions with limited pharmacy stock. Our online pharmacy bridges that gap, offering a discreet and reliable channel to obtain your prescription medication without unnecessary delays.
Quality & Safety
We partner with licensed international pharmacies that comply with Singapore’s regulatory standards and WHO Good Manufacturing Practices, ensuring every tablet meets stringent quality criteria.
Pricing & Access
Our platform negotiates competitive wholesale rates, passing savings directly to you. Generic Parlodel often costs significantly less than brand-only alternatives, and we provide a Lifetime 10 % discount on all reorders for registered members.
Discreet Delivery
Orders are processed in plain, tamper-evident packaging. Express shipping typically arrives within 7 days, while standard delivery takes up to 3 weeks, both with full tracking.
Frequently Asked Questions
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What should I do if I experience persistent nausea? Reduce the dose temporarily, take the tablet with a light snack, and discuss anti-emetic options with your prescriber.
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Can Parlodel be taken with other Parkinson’s medications? Yes, it is commonly combined with levodopa or MAO-B inhibitors, but dose adjustments may be needed to avoid excessive dopaminergic effects.
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Is there a risk of addiction with bromocriptine? Bromocriptine does not produce addictive cravings; however, abrupt discontinuation can lead to rebound prolactin elevation or motor worsening, so tapering under medical guidance is advised.
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How does Parlodel differ from other dopamine agonists like ropinirole? Parlodel has a longer half-life and is an ergot derivative, which can affect tolerability profiles and contraindications such as fibrotic disease.
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Will Parlodel affect my blood sugar levels? In some patients, bromocriptine improves insulin sensitivity, modestly lowering fasting glucose. Monitor your HbA1c if you have diabetes and discuss any changes with your doctor.
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Can I travel internationally with Parlodel? Yes, but keep the medication in its original container, carry a copy of the prescription, and be aware of any import restrictions in the destination country.
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Why is my blood pressure dropping after the first dose? Orthostatic hypotension is a known early effect; rise slowly, stay hydrated, and report persistent drops to your clinician.
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Is there a generic version of Parlodel available locally? Yes, several licensed manufacturers produce bromocriptine tablets that are bio-equivalent to the brand and generally more affordable.
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What monitoring is required while on Parlodel? Regular assessments of blood pressure, liver function, and prolactin levels are recommended, especially during dose escalations.
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Can I switch from the quick-release formulation used for diabetes to Parlodel? The dosing schedules differ; any switch should be overseen by a specialist to maintain glycemic control and avoid withdrawal effects.
Glossary
- Dopamine agonist
- A medication that stimulates dopamine receptors, mimicking the neurotransmitter’s action.
- Prolactin
- A hormone produced by the pituitary gland that promotes lactation; excess levels can cause reproductive disturbances.
- Orthostatic hypotension
- A drop in blood pressure upon standing, leading to dizziness or fainting.
Disclaimer
The information provided about Parlodel is for general knowledge only and does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. Readers are assumed to be responsible adults capable of making informed health decisions. Our online pharmacy offers access to Parlodel for individuals who may face limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
