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Penegra
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About Penegra
Generic Penegra (Sildenafil) is a phosphodiesterase-5 (PDE-5) inhibitor used to treat erectile dysfunction in adult men. Approved by Singapore’s Health Sciences Authority, this medication works by enhancing blood flow to the penis during sexual stimulation, helping men achieve and maintain an erection sufficient for intercourse. While its primary indication is erectile dysfunction, clinicians sometimes consider it for other vascular conditions, though such uses are not approved locally. Penegra is administered orally as a tablet, with common strengths of 25 mg, 50 mg, and 100 mg, and must be prescribed by a qualified healthcare professional.
What is Generic Penegra (Sildenafil)?
Generic Penegra (Sildenafil) belongs to the class of PDE-5 inhibitors, a subgroup of vasodilators that target the nitric oxide-cGMP pathway. First approved in Singapore in the early -s, the drug is marketed under the brand name Penegra by a regional distributor and is recognized as a prescription-only medication. It contains the active ingredient sildenafil citrate, the same compound found in the internationally known brand Viagra. Because it is a generic product, it offers the same pharmacologic profile as the brand counterpart while typically being more affordable for patients seeking reliable treatment for erectile dysfunction.
How Penegra Works
Penegra’s mechanism centers on the inhibition of the enzyme phosphodiesterase-5, which normally breaks down cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. During sexual arousal, nitric oxide released from nerve endings stimulates the production of cGMP, leading to relaxation of these muscles and increased arterial inflow. By blocking PDE-5, Penegra prolongs the presence of cGMP, sustaining smooth-muscle relaxation and facilitating an erection.
Pharmacokinetically, the tablet is rapidly absorbed, reaching peak plasma concentrations within 30-120 minutes. Food-especially high-fat meals-can delay absorption by up to an hour, but does not markedly affect overall exposure. The drug’s half-life is approximately 4 hours, allowing flexibility in timing relative to sexual activity. Metabolism occurs primarily via hepatic CYP3A4 enzymes, with renal excretion accounting for a small fraction of the eliminated dose. These properties explain why the 25 mg, 50 mg, and 100 mg strengths can be titrated to balance efficacy and tolerability across diverse patients.
Why Penegra is Used for Sexual Health Conditions
- Erectile Dysfunction (ED) - By enhancing the nitric oxide-cGMP pathway, Penegra directly counteracts the vascular insufficiency that underlies most cases of ED. Clinical trials demonstrate that up to 80 % of men achieve satisfactory erections within an hour of dosing.
- First-Line Recommendation - International guidelines, such as those from the Asia Pacific Society of Sexual Medicine, list PDE-5 inhibitors as the preferred initial therapy for uncomplicated ED, reserving invasive options for refractory cases.
- Rapid Onset and Flexible Dosing - The 25 mg dose offers a low-threshold option for men new to therapy, while the 100 mg dose is available for those who require a stronger effect, enabling clinicians to personalize treatment.
- Cost-Effectiveness - As a generic product, Penegra provides the same therapeutic benefit as branded alternatives at a lower price point, making it accessible to a broader segment of the Singaporean population.
- Predictable Safety Profile - Compared with other vasodilators, PDE-5 inhibitors have a well-characterized side-effect spectrum, allowing clinicians to anticipate and manage common adverse events.
Off-Label and Investigational Uses of Penegra
While Penegra is not approved for indications beyond erectile dysfunction in Singapore, some studies have explored its utility in pulmonary arterial hypertension (PAH) and certain forms of heart failure. These investigations suggest that sildenafil can improve exercise capacity and hemodynamics in PAH, yet a dedicated formulation (Revatio) is the approved product for that condition.
Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Penegra Right for You?
Penegra is generally suitable for adult men with a confirmed diagnosis of erectile dysfunction who are able to take oral medication and have no contraindications such as concurrent nitrate therapy or severe cardiovascular disease. Older patients may start with the 25 mg dose to assess tolerance, while individuals with renal or hepatic impairment should have dosing adjusted by their clinician. The medication is not recommended for use in women, children, or during pregnancy. As noted in the medication information, men with conditions that predispose them to priapism (e.g., sickle-cell disease) should discuss risks with their doctor before initiating therapy.
Taking Penegra Effectively
- Timing: Consume the tablet with water about 30-60 minutes before anticipated sexual activity. If a high-fat meal is planned, allow an additional hour for absorption.
- Frequency: Do not exceed one dose per 24 hours. The medication can be used on an as-needed basis or daily, depending on the prescribing physician’s recommendation.
- Missed Dose: If a dose is forgotten and sexual activity is still anticipated within the next few hours, take it now; otherwise, skip it and resume the regular schedule-do not double the dose.
- Travel Considerations: Keep tablets in their original packaging, carry a copy of the prescription, and store them at room temperature away from moisture.
Understanding Side Effects and How to Manage Them
Most adverse events are mild and stem from the drug’s vasodilatory action.
- Headache: Caused by transient dilation of cerebral vessels. Over-the-counter analgesics such as acetaminophen can provide relief.
- Flushing: Results from peripheral vasodilation, especially in the face and neck. Wearing loose clothing and staying in a cool environment may reduce discomfort.
- Dyspepsia: Sildenafil can relax the lower esophageal sphincter. Taking the tablet with food (except a high-fat meal) often mitigates stomach upset.
- Vision Changes: Rarely, users report a blue-tinted vision or increased sensitivity to light, reflecting PDE-6 inhibition in retinal cells. If visual disturbances persist, seek immediate medical attention.
Serious side effects-such as chest pain, sudden loss of vision, or an erection lasting longer than four hours (priapism)-require
