Buy Seroflo Inhaler
Seroflo Inhaler

$34.00
Category
Asthma & COPD Care
Active Ingredients
Fluticasone, Salmeterol
Delivery
Airmail (14-21 days) | EMS trackable (5-9 days)
Prescription
Issued on site / Included
Availability
In Stock
Product is shipped in a fully discreet envelope with no content disclosure, including all required documentation inside

Seroflo Inhaler Properties

Active Ingredients
Fluticasone, Salmeterol
Primary Category
Respiratory
Pharmacological Class
Inhaled Corticosteroid, Long-Acting Beta-2 Adrenergic Agonist (LABA)
Minor Side Effects
Throat Irritation , Hoarseness , Headache
Moderate Side Effects
Headache , Muscle Cramps , Tremors , Cough , Oral Thrush
Dosage Forms
Inhalation Powder
Administration Route
Inhalation
Mechanism of Action
Combines a corticosteroid to reduce inflammation in the airways with a long-acting bronchodilator to relax airway muscles, making breathing easier for people with asthma or COPD.
Prescription Status
Rx
Manufacturer
Cipla
Patient Summary
Used regularly to help manage asthma and COPD by reducing inflammation and opening up the airways.
Onset Time
Salmeterol: Within 10-20 minutes; Fluticasone: Onset of full effect over several days or weeks
Duration
12 hours (for individual dose effects)
Storage Instructions
Store at room temperature, away from moisture. Do not freeze.
Age Restrictions
Varies by specific product and indication, generally adults and children over certain ages.
Pregnancy Use
Consult doctor before use during pregnancy or breastfeeding
Alternative Drugs
Symbicort , Advair

About Seroflo Inhaler

Seroflo Inhaler is a fixed-dose combination inhaler that delivers fluticasone (an inhaled corticosteroid) and salmeterol (a long-acting β₂-agonist) to help control chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD). It is designed for twice-daily use and is available in several dose strengths (25 µg/50 µg, 25 µg/125 µg, and 25 µg/250 µg). This article provides a deeper look at how the medication works, why it is prescribed, and practical tips for safe and effective use.

Table of Contents

What is Generic Seroflo (Fluticasone, Salmeterol)?

Generic Seroflo (Fluticasone, Salmeterol) belongs to the class of combination inhaled corticosteroid/long-acting β₂-agonist (ICS/LABA) products. It is approved by Singapore’s Health Sciences Authority (HSA) for maintenance treatment of asthma and for preventing exacerbations in COPD. The inhaler’s design ensures consistent delivery of both agents to the lower airways, optimizing anti-inflammatory activity while providing sustained bronchodilation.

How Seroflo Works

Fluticasone exerts its effect by binding to glucocorticoid receptors in airway epithelial cells, suppressing the transcription of inflammatory cytokines, chemokines, and adhesion molecules. This reduces airway edema, mucus production, and eosinophilic infiltration. Salmeterol, on the other hand, selectively stimulates β₂-adrenergic receptors on bronchial smooth muscle, triggering cyclic AMP production that relaxes the muscle fibers for up to 12 hours. By pairing these mechanisms, Seroflo delivers both rapid symptom relief (through bronchodilation) and long-term control of airway inflammation.

Pharmacokinetically, fluticasone has minimal systemic absorption; the fraction that reaches systemic circulation is largely metabolised by CYP3A4 in the liver. Salmeterol is also extensively metabolised by CYP3A4, with an oral bioavailability of less than 5 %. The inhaled route bypasses first-pass metabolism, providing high pulmonary concentrations while limiting systemic exposure.

Why Seroflo is Used for Respiratory Conditions

  • Asthma maintenance - Fluticasone’s anti-inflammatory action reduces airway hyper-responsiveness, while salmeterol maintains bronchodilation, decreasing the need for rescue inhalers. Guidelines such as GINA place low-dose ICS/LABA combos as a step-up option after low-dose ICS alone.
  • COPD symptom control - In patients with moderate-to-severe COPD, the combination improves lung function (FEV₁) and reduces exacerbation frequency compared with either component alone.
  • Improved adherence - A single inhaler delivering both agents simplifies the regimen, which is associated with higher adherence rates versus separate inhalers.
  • Dose flexibility - The three available strengths allow clinicians to tailor therapy to disease severity, body size, and previous response.
  • Evidence-based superiority - Large randomized controlled trials (e.g., the ISOLDE and TORCH studies) demonstrated that adding an LABA to an inhaled corticosteroid yields better outcomes than increasing corticosteroid dose alone, with comparable safety.

Off-Label and Investigational Uses of Seroflo

Current peer-reviewed evidence does not support widespread off-label use of Seroflo beyond asthma and COPD. Some small studies have explored its role in bronchiectasis and certain allergic airway diseases, but these investigations remain preliminary. Off-label use should only be considered under the supervision of a qualified healthcare provider.

Is Seroflo Right for You?

Seroflo is generally suitable for adults and adolescents with persistent asthma or moderate-to-severe COPD who require both anti-inflammatory and bronchodilator therapy. It is not recommended for patients with a known hypersensitivity to either component, for those who experience paradoxical bronchospasm, or for individuals with uncontrolled cardiovascular disease. Pregnant or lactating women should discuss risks with their provider, as systemic exposure is low but not entirely absent. Renal or hepatic impairment does not usually require dose adjustment because the drug is primarily metabolised in the lungs and liver with limited renal elimination.

Taking Seroflo Effectively

  • Timing - Inhale the prescribed dose twice daily, ideally 12 hours apart, and at the same times each day to maintain steady drug levels.
  • Inhalation technique - Exhale fully, place the mouthpiece between the teeth, seal lips, and inhale forcefully and deeply. Hold breath for 10 seconds before exhaling slowly.
  • Food and drink - No specific dietary restrictions, but avoid drinking alcohol in excess as it may increase the risk of systemic side effects.
  • Missed dose - If a dose is missed for less than 12 hours, take it as soon as remembered; if more than 12 hours have passed, skip the missed dose and resume the regular schedule. Do not double-dose.
  • Travel - Keep the inhaler in a cool, dry place; avoid extreme temperatures that could affect propellant performance.

Understanding Side Effects and How to Manage Them

  • Oropharyngeal candidiasis - Occurs because fluticasone can suppress local immunity. Rinse the mouth with water and spit after each inhalation; consider using a spacer device.
  • Hoarseness - Similar mechanism; mouth rinse helps, and a short course of topical steroids may be prescribed if persistent.
  • Tremor or palpitations - Result from salmeterol’s β₂-agonist activity. Usually mild; if severe, discuss dose reduction with your clinician.
  • Systemic corticosteroid effects - Rare at inhaled doses but may include adrenal suppression or bone density loss with long-term high-dose use. Periodic monitoring of bone health is advisable.
  • Serious adverse events - Include paradoxical bronchospasm, hypersensitivity reactions, and increased risk of pneumonia in COPD patients. Seek immediate medical attention if you experience sudden breathlessness, swelling of the face or throat, or high-grade fever.

Buying Seroflo from Our Online Pharmacy

Why Choose Our Service?

Our online pharmacy bridges gaps in local availability, offering a discreet and convenient way to obtain Seroflo when traditional pharmacies face stock shortages or when you prefer home delivery.

Quality & Safety

We partner with licensed international pharmacies that operate under strict regulatory frameworks, ensuring every inhaler meets WHO-certified manufacturing standards and carries a full batch-traceability record.

Pricing & Access

Competitive pricing makes the generic version of Seroflo more affordable than many brand-name alternatives. Repeat customers enjoy a lifetime 10 % discount on all reorders, and we provide flexible payment options, including credit card and local e-wallets.

Discreet Delivery

Orders are shipped in unmarked packaging. Express delivery typically arrives within 7 days, while standard shipping takes up to 3 weeks, with tracking available throughout the journey.

Frequently Asked Questions

  • What is the difference between Seroflo and other inhaled corticosteroid/LABA combos? Seroflo delivers fluticasone at a fixed low dose (25 µg) combined with varying strengths of salmeterol, offering a balance of anti-inflammatory potency and bronchodilation that may suit patients sensitive to higher steroid doses.

  • Can I use a spacer with Seroflo? Yes, a spacer can improve drug deposition in the lungs and reduce oropharyngeal side effects, especially for patients with coordination difficulties.

  • How quickly will I notice symptom improvement? Bronchodilation from salmeterol begins within minutes, while the anti-inflammatory effect of fluticasone builds over several days. Most patients experience noticeable relief within 1-2 weeks of consistent use.

  • Is Seroflo safe for elderly patients? The inhaled formulation limits systemic exposure, making it generally safe for older adults, but clinicians may monitor for cardiovascular side effects and consider lower LABA doses if needed.

  • What should I do if I experience throat irritation? Rinse your mouth after each inhalation and stay hydrated. Persistent irritation warrants a brief review by your healthcare provider.

  • Can Seroflo be used as rescue medication? No. It is intended for maintenance therapy. For acute relief, a short-acting bronchodilator such as albuterol should be used.

  • How does Seroflo compare to oral corticosteroids? Inhaled delivery targets the lungs directly, achieving comparable anti-inflammatory outcomes with far fewer systemic side effects than oral steroids.

  • Is there a risk of dependence on the LABA component? Tolerance to β₂-agonists is uncommon at the prescribed twice-daily dose, but abrupt discontinuation may unmask underlying bronchoconstriction, so any dose changes should be medically supervised.

  • Will using Seroflo affect my ability to drive? Most patients experience no impairment. However, if you notice tremor, palpitations, or dizziness, avoid operating vehicles until symptoms resolve.

  • Is Seroflo covered by Singapore’s Medisave or private insurance? Coverage varies by plan. Verify with your insurer; our service can provide receipts that may assist in claim submissions.

Glossary

Inhaled corticosteroid (ICS)
A medication delivered via inhalation that reduces airway inflammation by activating glucocorticoid receptors in the respiratory epithelium.
Long-acting β₂-agonist (LABA)
A bronchodilator that relaxes airway smooth muscle for up to 12 hours through stimulation of β₂-adrenergic receptors.
CYP3A4
An enzyme in the liver and intestinal wall that metabolises many drugs, including fluticasone and salmeterol, influencing their systemic clearance.

Disclaimer

The information provided about Seroflo is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Seroflo for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

External Resources about Seroflo Inhaler

Information Prepared By

Nawin Kittisak
Platform Manager & Website Administrator
Vikneswaran V Paranjothy
General Practitioner