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Prandin
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About Prandin
Generic Prandin (Repaglinide) is a prescription-only oral medication used to improve blood-sugar control in adults with type 2 diabetes. It belongs to the meglitinide class and works by stimulating the pancreas to release insulin in response to meals. In Singapore the drug is regulated by the Health Sciences Authority and is available through pharmacies with a valid prescription. Patients often choose it when rapid, short-acting insulin release is needed to match post-prandial glucose spikes.
What is Generic Prandin (Repaglinide)?
Generic Prandin (Repaglinide) is a short-acting insulin secretagogue that falls under the meglitinide family of antihyperglycemic agents. It received approval from major regulatory agencies-including the U.S. FDA and the European Medicines Agency-based on robust clinical trials that demonstrated its ability to lower glycated hemoglobin (HbA1c) by roughly .5-1. % when added to diet and exercise. In Singapore the medication is classified as a prescription drug and is dispensed in tablet form at strengths of .5 mg, 1 mg, and 2 mg.
How Prandin Works
Prandin binds to the sulfonylurea receptor 1 (SUR1) component of the ATP-sensitive potassium (K⁺-ATP) channels on pancreatic β-cells. This binding closes the channels, leading to membrane depolarisation, calcium influx, and a rapid burst of insulin secretion. Because the drug has a short half-life (about 1 hour) and is quickly cleared by the kidneys, its glucose-lowering effect peaks within 30 minutes and wanes within 2-3 hours, making it well-suited for controlling post-meal glucose excursions without causing prolonged hypoglycaemia.
Why Prandin Is Used for Diabetes Conditions
- Targeted post-prandial control: By acting quickly after a meal, Prandin reduces the spike in blood glucose that occurs after eating, which is a key driver of overall HbA1c levels.
- Flexible dosing: Patients can take a tablet before each main meal, allowing dose adjustments based on carbohydrate intake and lifestyle.
- Complementary to other agents: It can be combined with metformin or a GLP-1 receptor agonist when basal insulin or other oral agents do not achieve target glycaemic control.
- Guideline placement: International diabetes guidelines list meglitinides as second-line options after metformin when post-prandial hyperglycaemia persists.
- Cost-effectiveness: As a generic product, Prandin offers a lower-cost alternative to brand-name meglitinides while delivering equivalent pharmacodynamic effects.
Is Prandin Right for You?
Prandin is most appropriate for adults with type 2 diabetes who have pronounced post-prandial hyperglycaemia and who can adhere to a meal-timed dosing schedule. It is generally well-tolerated in patients with normal renal function, but dose reductions are advised for those with moderate renal impairment (eGFR 30-59 mL/min/1.73 m²) because the drug is cleared renally. Pregnant or nursing women should avoid Prandin unless a specialist explicitly recommends it, as safety data are limited. Elderly patients may benefit from the short-acting profile, which reduces the risk of prolonged hypoglycaemia compared with sulfonylureas.
Taking Prandin Effectively
- Timing: Take one tablet 15-30 minutes before each main meal. If a meal is missed, skip the dose; do not take it later.
- Food interactions: High-fat meals can delay absorption, so maintain consistent meal composition when possible.
- Missed dose: If you forget a dose and the next meal is more than 2 hours away, omit the missed tablet and resume the regular schedule at the next meal.
- Travel tips: Keep the tablets in their original container, stored at room temperature away from moisture. Carry a short-acting glucose source (e.g., glucose tablets) in case of hypoglycaemia.
- Alcohol: Moderate alcohol consumption is permissible, but excessive intake can potentiate hypoglycaemia; monitor glucose closely.
Understanding Side Effects and How to Manage Them
The most common side effects-hypoglycaemia, nausea, and dizziness-are directly linked to the drug’s insulin-stimulating action. To minimise hypoglycaemia, ensure meals contain carbohydrates and avoid excessive dosing; a typical starting dose is .5 mg before the first meal, with gradual titration. Mild nausea often resolves within a few days; taking the tablet with a small amount of food can help. If dizziness persists, check blood glucose; low readings require immediate carbohydrate intake. Rare but serious reactions-such as severe skin rash or hepatic dysfunction-warrant prompt medical evaluation.
Buying Prandin from Our Online Pharmacy
Why Choose Our Service?
Accessing Prandin in Singapore can be challenging for patients without a local prescription or those seeking a cost-effective alternative. Our online pharmacy bridges that gap by delivering verified, prescription-only medications directly to your doorstep.
Quality & Safety
We partner with licensed international pharmacies that operate under stringent regulatory frameworks, ensuring every batch of Generic Prandin (Repaglinide) meets WHO-recognized quality standards.
Pricing & Access
Because we source the generic formulation, you benefit from significant savings compared with brand-name options. New customers receive a 10 % discount on their first order, and repeat purchases enjoy loyalty pricing.
Discreet Delivery
Orders are shipped in unbranded, tamper-evident packaging. Standard delivery arrives within 3 weeks, while express shipping reaches most Singapore addresses in approximately 7 days.
Frequently Asked Questions
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How quickly does Prandin lower blood sugar after a meal? Prandin begins to work within 15-30 minutes, with peak insulin release occurring around 1 hour post-dose, making it ideal for controlling post-prandial glucose spikes.
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Can I take Prandin with other diabetes medicines? Yes. It is often combined with metformin or a GLP-1 receptor agonist when basal control is insufficient, but dose adjustments may be needed to avoid hypoglycaemia.
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What should I do if I experience low blood sugar? Treat mild hypoglycaemia immediately with 15 g of fast-acting carbohydrate (e.g., glucose tablets) and re-check your level after 15 minutes. Seek medical attention if symptoms persist.
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Is dose adjustment required for kidney problems? Patients with moderate renal impairment should start at the lowest dose (.5 mg) and may require dose reductions based on glucose monitoring and renal function tests.
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Can I use Prandin during Ramadan fasting? Because Prandin is taken before meals, it can be timed with the pre-dawn (Suhoor) and pre-sunset (Iftar) meals, but close glucose monitoring is essential to prevent hypoglycaemia.
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Why does Prandin sometimes cause nausea? The rapid insulin surge can affect gastric motility. Taking the tablet with a small amount of food and starting at the lowest dose often reduces this effect.
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Is there any advantage of Prandin over sulfonylureas? Prandin’s short duration limits the risk of prolonged hypoglycaemia, especially in elderly patients or those with irregular eating patterns.
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How long can I stay on Prandin therapy? It can be used indefinitely as part of a comprehensive diabetes management plan, provided regular clinical review confirms continued efficacy and safety.
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What is the difference between brand-name Prandin and the generic version? The generic contains the same active ingredient (repaglinide) in identical strength and formulation, offering the same therapeutic effect at a lower price.
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Do I need a new prescription each time I reorder? Yes, a valid prescription from a licensed healthcare professional is required for each order, in accordance with Singapore regulations.
Glossary
- Meglitinide
- A class of oral hypoglycaemic agents that stimulate rapid, short-lasting insulin release by closing pancreatic β-cell K⁺-ATP channels.
- HbA1c
- Glycated haemoglobin, reflecting average blood-glucose levels over the previous 2-3 months; a key marker for diabetes control.
- eGFR
- Estimated glomerular filtration rate, used to assess kidney function and guide medication dosing.
- Hypoglycaemia
- A condition where blood glucose falls below normal levels, typically <70 mg/dL, causing symptoms such as shakiness, sweating, and confusion.
- Pharmacokinetics
- The study of how a drug is absorbed, distributed, metabolised, and excreted by the body.
Disclaimer
The information provided about Prandin is for general knowledge only and does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Prandin for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
