Buy Revatio
Revatio
Revatio Properties
About Revatio
Revatio is a prescription-only medication approved in Singapore for the treatment of pulmonary arterial hypertension (PAH). It contains the active ingredient sildenafil, a phosphodiesterase-5 (PDE5) inhibitor that helps relax the blood vessels in the lungs, improving oxygen delivery and exercise capacity. While its primary indication is PAH, clinicians sometimes consider it for related circulatory conditions after careful evaluation. This article explains how Revatio works, why it is chosen for heart- and circulation-related disorders, and what patients should know before using it.
What is Revatio?
Revatio is the brand-name formulation of sildenafil, specifically marketed for pulmonary arterial hypertension. Approved by Singapore’s Health Sciences Authority (HSA) in 2005, the product is manufactured by Pfizer and available only with a physician’s prescription. As a PDE5 inhibitor, Revatio belongs to the class of vasodilators that target the nitric-oxide/cGMP pathway in the pulmonary vasculature. The standard adult dose in Singapore is a 20 mg tablet taken once daily, although the dose may be adjusted based on clinical response and tolerability.
How Revatio Works
Sildenafil blocks the enzyme phosphodiesterase-5, which normally degrades cyclic guanosine monophosphate (cGMP). By preserving cGMP levels, Revatio enhances the nitric-oxide-mediated relaxation of smooth muscle cells in the pulmonary arteries. This vasodilation reduces pulmonary vascular resistance, lowers the workload on the right side of the heart, and improves overall cardiac output.
Key pharmacokinetic points include:
- Absorption: Peak plasma concentrations occur within 30-60 minutes after oral ingestion.
- Distribution: The drug is highly protein-bound (≈96 %).
- Metabolism: Primarily metabolized by hepatic CYP3A4 enzymes, with minor contributions from CYP2C9.
- Elimination: A half-life of roughly 4 hours; metabolites are excreted mainly in the feces (≈80 %) and urine (≈13 %).
These properties explain the rapid onset of symptom relief and guide dosing schedules, especially when co-administered with CYP3A4 inhibitors or in patients with liver impairment.
Why Revatio Is Used for Heart & Circulation Conditions
- Targeted pulmonary vasodilation: By lowering pulmonary arterial pressure, Revatio directly addresses the pathophysiology of PAH, where elevated resistance hampers oxygen exchange.
- Improved exercise capacity: Clinical trials show a mean increase of 30-40 meters in the six-minute walk test after 12 weeks of therapy.
- Guideline endorsement: The 2022 ESC/ERS guidelines list PDE5 inhibitors-including Revatio-as first-line agents for patients with WHO Group 1 PAH, either as monotherapy or in combination with endothelin-receptor antagonists.
- Oral convenience: Compared with injectable prostacyclin analogues, Revatio offers a simple once-daily pill, enhancing adherence.
- Cost-effectiveness: While brand-named, Revatio often incurs lower overall expenses than intravenous options, especially when insurance coverage is limited.
In comparison, endothelin-receptor antagonists such as bosentan focus on a different molecular pathway and may have hepatic monitoring requirements, whereas prostacyclin agents require continuous infusion and carry higher infection risks.
Off-Label and Investigational Uses of Revatio
Limited peer-reviewed data explore sildenafil’s utility beyond PAH. Small randomized trials suggest potential benefits in high-altitude pulmonary edema and Raynaud’s phenomenon, but these indications are not approved by Singapore’s HSA. Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Revatio Right for You?
Revatio is most appropriate for adults diagnosed with PAH who require long-term vasodilatory therapy. Ideal candidates are individuals experiencing reduced exercise tolerance, dyspnea on exertion, or right-heart strain confirmed by echocardiography.
Patients with severe hepatic impairment, uncontrolled hypotension, or recent non-arteritic optic neuropathy should avoid Revatio. While the medication is contraindicated in pregnancy, limited data suggest caution rather than absolute prohibition; clinicians typically advise women of childbearing potential to use effective contraception. Elderly patients may need dose adjustments due to altered metabolism.
Taking Revatio Effectively
- Timing: Take the 20 mg tablet with or without food at the same time each day to maintain stable plasma levels.
- Interactions: Avoid potent CYP3A4 inhibitors (e.g., ketoconazole, erythromycin) as they increase sildenafil exposure. Grapefruit products can have a similar effect.
- Missed dose: If a dose is forgotten, take it as soon as remembered unless it is within 12 hours of the next scheduled dose; then skip the missed tablet and resume the regular schedule.
- Travel considerations: When flying long distances, keep the medication in carry-on luggage to prevent temperature fluctuations.
Understanding Side Effects and How to Manage Them
Most adverse events stem from systemic vasodilation and PDE6 inhibition in the retina.
- Common, mild effects: Headache, facial flushing, dyspepsia, and nasal congestion. These usually resolve within a few days as the body adapts. Simple measures-adequate hydration, avoiding spicy foods, and using a humidifier-can mitigate discomfort.
- Visual disturbances: A bluish tinge to vision or increased sensitivity to light occurs in ≤5 % of users, reflecting PDE6 inhibition in retinal photoreceptors. Reduce screen brightness and wear sunglasses outdoors if needed.
- Serious concerns: Persistent chest pain, hypotension, or sudden loss of vision warrant immediate medical attention. While rare, these signals possible cardiovascular complications or non-arteritic ischemic optic neuropathy.
Counselling patients on the expected timeline of side effects improves adherence and reduces unnecessary discontinuations.
Buying Revatio from Our Online Pharmacy
Why Choose Our Service?
Access to Revatio can be challenging when local pharmacies have limited stock. Our online pharmacy bridges that gap, delivering the medication discreetly to your doorstep across Singapore.
Quality & Safety
We partner with licensed international pharmacies that operate under stringent regulatory frameworks, ensuring each Revatio tablet meets the purity standards set by the HSA and WHO.
Pricing & Access
Because Revatio is a brand product, its price reflects the manufacturing pedigree, yet we negotiate bulk rates that often translate into savings of up to 30 % compared with brick-and-mortar outlets. First-time customers enjoy a Lifetime 10 % discount on all reorders.
Discreet Delivery
Orders are packaged in plain, unmarked envelopes. Express shipping reaches most districts within 7 days, while standard delivery arrives within 3 weeks, both with full tracking.
Frequently Asked Questions
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Can Revatio be taken with antihypertensive drugs? Yes, but clinicians usually monitor blood pressure closely, especially during the initial weeks, because combined vasodilatory effects may cause symptomatic hypotension.
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Is Revatio effective for erectile dysfunction? Although sildenafil treats both conditions, Revatio is formulated and dosed specifically for PAH. For erectile dysfunction, physicians typically prescribe the 50 mg or 100 mg tablets of Viagra, not Revatio.
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How does Revatio compare with bosentan? Bosentan targets the endothelin pathway, whereas Revatio works on the nitric-oxide/cGMP axis. Clinical trials suggest similar improvements in walk distance, but bosentan requires regular liver function monitoring, a consideration for long-term safety.
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Will alcohol increase side effects? Alcohol can potentiate hypotension and dizziness. Moderate consumption is permissible, but patients should avoid excessive intake, particularly after the first few weeks of therapy.
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Can I travel internationally with Revatio? Yes, provided you carry the prescription label and keep the medication in its original packaging. Some countries may request documentation, so a copy of the prescribing doctor’s note is advisable.
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What should I do if I miss a dose while on vacation? Take the missed tablet as soon as you remember, unless it is less than 12 hours before the next scheduled dose. In that case, skip the missed dose to avoid double-dosing, and resume your regular schedule.
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Is there any risk of drug interaction with over-the-counter supplements? Certain herbal products, such as St John’s wort, induce CYP3A4 and may lower sildenafil levels, potentially reducing efficacy. Discuss any supplement use with your healthcare provider.
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How often should follow-up appointments occur? After initiating Revatio, a follow-up visit at 4-6 weeks is common to assess symptom improvement and tolerance. Subsequent visits are typically spaced every 3-6 months, contingent on clinical stability.
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Can Revatio be used in children? Current approvals limit use to adults. Pediatric investigations are ongoing, but until robust data emerge, Revatio remains an adult-only therapy in Singapore.
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What happens if I stop taking Revatio abruptly? Discontinuation may lead to a rapid rise in pulmonary arterial pressure, potentially worsening symptoms. Any dose changes should be coordinated with a physician to taper safely if needed.
Glossary
- Phosphodiesterase-5 (PDE5)
- An enzyme that degrades cGMP, a messenger molecule that promotes smooth-muscle relaxation in blood vessels.
- cGMP (Cyclic guanosine monophosphate)
- A secondary messenger that mediates nitric-oxide-induced vasodilation, crucial for lowering vascular resistance.
- Pulmonary arterial hypertension (PAH)
- A progressive condition characterized by elevated pressure in the pulmonary arteries, leading to right-heart strain and limited exercise capacity.
Disclaimer
The information provided about Revatio is for general knowledge only and does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Revatio for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
