Buy Lanoxin
Lanoxin
Lanoxin Properties
About Lanoxin
Lanoxin (digoxin) is a cardiac glycoside prescribed to improve heart muscle contractility and to control ventricular rate in certain arrhythmias. It belongs to the class of positive inotropic agents and is commonly used in the management of chronic heart failure and atrial fibrillation. In Singapore, Lanoxin is available by prescription only and is regulated under the Health Sciences Authority. While its primary indication is for cardiovascular conditions, clinicians may consider off-label applications under strict supervision.
What is Lanoxin?
Lanoxin is a brand formulation of digoxin, a naturally derived compound extracted from the foxglove plant (Digitalis lanata). First approved by the US FDA in the -s, it has been incorporated into Singapore’s formulary for the treatment of heart failure and atrial fibrillation. Manufactured by Pfizer, Lanoxin is supplied as a .125 mg tablet, the standard dose for most adult patients. Its bioequivalence to other digoxin products has been demonstrated in multiple pharmacokinetic studies, ensuring consistent therapeutic levels across batches.
How Lanoxin Works
Digoxin exerts its effect by inhibiting the sodium-potassium ATP-ase pump in cardiac myocytes. This inhibition leads to an increase in intracellular sodium, which in turn reduces the activity of the sodium-calcium exchanger. The net result is a rise in intracellular calcium concentration, enhancing the force of myocardial contraction (positive inotropy). In addition to its inotropic action, digoxin activates vagal tone, slowing conduction through the atrioventricular node and thereby controlling ventricular rate in atrial fibrillation. Oral absorption is rapid, with peak plasma concentrations reached within 1-2 hours. The drug’s elimination half-life ranges from 36 to 48 hours in individuals with normal renal function, allowing once-daily dosing for most patients. Renal clearance predominates; therefore, dose adjustments are essential in patients with impaired kidney function.
Why Lanoxin is Used for Cardiovascular Health Conditions
- Chronic Heart Failure: By increasing contractile strength, digoxin improves cardiac output, alleviating symptoms such as dyspnoea and fatigue. It is recommended as an adjunct to guideline-directed therapy in patients who remain symptomatic despite optimal use of ACE inhibitors, beta-blockers, and diuretics.
- Atrial Fibrillation with Rapid Ventricular Response: The vagomimetic effect slows atrioventricular nodal conduction, helping maintain a controlled ventricular rate without the need for additional rate-controlling agents.
- Improved Exercise Tolerance: Clinical trials have shown modest gains in exercise capacity and quality-of-life scores when digoxin is added to standard heart-failure regimens.
- Cost-Effective Therapy: As a long-standing generic, digoxin offers a low-cost alternative to newer agents, making it attractive in resource-constrained settings.
In treatment guidelines, digoxin is positioned as a second-line option after optimisation of neurohormonal blockade. Its unique mechanism distinguishes it from beta-blockers, calcium-channel blockers, and newer sodium-glucose cotransporter-2 (SGLT2) inhibitors, which act principally through neurohormonal modulation rather than direct inotropic enhancement.
Off-Label and Investigational Uses of Lanoxin
Some clinicians have explored digoxin for rate control in postoperative atrial fibrillation and for symptom relief in hypertrophic cardiomyopathy. Evidence consists mainly of small observational studies and a few randomized trials suggesting modest benefit, but these uses are not endorsed by the Health Sciences Authority in Singapore. Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Lanoxin Right for You?
Lanoxin is suitable for adults with symptomatic heart failure (NYHA class II-IV) or atrial fibrillation requiring rate control, provided they have stable renal function and no contraindications such as high-grade AV block. Elderly patients often require lower initial doses due to reduced clearance. Pregnant or breastfeeding women should avoid digoxin unless the benefits clearly outweigh the risks, as placental transfer occurs. Patients with severe electrolyte disturbances (e.g., hypokalaemia) are at heightened risk of toxicity and should have these abnormalities corrected before initiation.
Taking Lanoxin Effectively
The tablet should be taken with a glass of water, preferably on an empty stomach to enhance absorption, although food does not significantly alter bioavailability. Consistency in timing helps maintain steady plasma concentrations; most regimens recommend a morning dose. If a dose is missed, take it as soon as remembered unless it is close to the next scheduled dose-then skip the missed tablet and continue with the regular schedule. Travel across time zones may require dose timing adjustments to align with the local day-night cycle. Regular monitoring of serum digoxin levels (target range .5-2. ng/mL) and renal function is essential, especially after dose changes.
Understanding Side Effects and How to Manage Them
Common adverse effects-such as nausea, visual disturbances (yellow-green halos), and mild arrhythmias-stem from digoxin’s influence on cardiac electrophysiology and electrolyte balance. To mitigate nausea, take the tablet with a small amount of food or consider a slower-release formulation if available. Visual symptoms often precede toxicity; patients should report any colour-vision changes promptly. Electrolyte monitoring is crucial; maintaining serum potassium above 4 mmol/L reduces the risk of arrhythmias. Serious toxicity, manifesting as severe bradycardia, ventricular arrhythmias, or hyperkalaemia, warrants immediate medical attention and may require administration of digoxin-specific antibody fragments (Digibind).
Buying Lanoxin from Our Online Pharmacy
Obtaining Lanoxin through our online pharmacy offers a discreet, reliable way to access this essential medication, especially for patients facing supply constraints in traditional outlets.
Why Choose Our Service?
Our platform connects you with licensed international pharmacies that comply with Singapore’s regulatory standards, ensuring authenticity and safety. By purchasing through us, you benefit from streamlined ordering, secure payment processing, and dedicated customer support.
Quality & Safety
We partner with accredited suppliers that adhere to WHO Good Manufacturing Practices, guaranteeing that each tablet meets stringent potency and purity criteria.
Pricing & Access
Lanoxin is competitively priced, with additional savings for bulk orders. Generic digoxin alternatives are also listed, providing further cost-effective options for long-term therapy.
Discreet Delivery
Orders are packaged in neutral, tamper-evident containers. Express shipping typically arrives within 7 days, while standard delivery may take up to 3 weeks, all with full confidentiality.
Frequently Asked Questions
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Can I take Lanoxin with other heart medications? Yes, digoxin is often co-prescribed with ACE inhibitors, beta-blockers, or diuretics. However, drug-interaction checks are essential, especially with medications that affect potassium levels or cardiac conduction.
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How often do I need blood tests while on Lanoxin? Serum digoxin concentrations should be checked after the first week of therapy and after any dose adjustment. Renal function and electrolytes are reviewed concurrently to detect early signs of toxicity.
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What should I do if I experience visual halos? Yellow-green visual disturbances can signal digoxin accumulation. Stop the medication and contact your healthcare provider promptly for evaluation and possible dosage reduction.
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Is Lanoxin safe for people with chronic kidney disease? Kidney impairment prolongs digoxin’s half-life, necessitating lower starting doses and more frequent monitoring. Your clinician will tailor the regimen based on your renal function.
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Can Lanoxin be taken during Ramadan fasting? Since food does not critically affect absorption, the tablet can be taken during non-fasting hours. Align the dose with your preferred time of break-fast to maintain consistency.
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Are there lifestyle restrictions while on Lanoxin? Maintaining a balanced diet rich in potassium (e.g., bananas, leafy greens) helps prevent toxicity. Avoid excessive alcohol, which can exacerbate cardiac arrhythmias.
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How does digoxin differ from newer heart-failure drugs? Unlike SGLT2 inhibitors or neprilysin blockers that modify neurohormonal pathways, digoxin directly enhances myocardial contractility and modulates AV nodal conduction, offering a distinct therapeutic mechanism.
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Is there a generic version of Lanoxin available in Singapore? Yes, several generic digoxin products are marketed under different brand names. They are bioequivalent and often priced lower than the branded Lanoxin.
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What causes digoxin toxicity besides overdose? Electrolyte imbalances (especially low potassium or magnesium), renal insufficiency, and drug interactions (e.g., amiodarone) can raise serum digoxin levels even at standard doses.
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Can I travel internationally with Lanoxin? Carry a copy of your prescription and a pharmacist’s note if required by customs. Our service can ship directly to most overseas destinations, ensuring you stay stocked during prolonged trips.
Glossary
- Positive Inotrope
- A medication that increases the force of cardiac muscle contraction, improving cardiac output.
- AV Node
- The atrioventricular node, a critical electrical relay that regulates the timing of impulses between the atria and ventricles.
- Serum Digoxin Level
- The concentration of digoxin measured in the blood, used to assess therapeutic efficacy and avoid toxicity.
Disclaimer
The information provided about Lanoxin is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Lanoxin for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
