Buy Imdur

Imdur

Imdur is a prescription-only nitrate medication used in Singapore to prevent angina pectoris and manage certain heart conditions. The tablet contains isosorbide mononitrate, a long-acting nitrate that helps relax blood vessels, reducing the heart’s workload. Approved by the Health Sciences Authority, Imdur is taken once daily and is intended for adults with chronic stable angina or other ischemic heart disease where nitrate therapy is appropriate. While its primary indication is chest-pain prevention, clinicians sometimes consider it for other cardiovascular scenarios after careful evaluation.

What is Imdur?

Imdur is a brand-name tablet that delivers the active ingredient isosorbide mononitrate, a nitrate derivative that belongs to the class of vasodilators. First approved in the United States in 1995, it received Health Sciences Authority clearance for use in Singapore shortly thereafter. Imdur is manufactured by AstraZeneca, a globally recognised pharmaceutical company, and is available by prescription only. Generic equivalents of isosorbide mononitrate are also marketed in Singapore, offering comparable bioavailability at lower cost.

How Imdur Works

Isosorbide mononitrate acts as a nitric-oxide donor. After oral absorption, it is converted to nitric oxide within vascular smooth-muscle cells. This messenger molecule stimulates guanylate cyclase, raising cyclic-GMP levels and causing relaxation of the smooth muscle. The resulting vasodilation lowers both preload and afterload, decreasing myocardial oxygen demand. Pharmacokinetic data show an oral onset of action within 30 minutes, a peak effect at 3-4 hours, and a half-life of roughly 5 hours, supporting once-daily dosing. The drug is largely excreted unchanged in urine, with minimal hepatic metabolism.

Why Imdur is Used for Heart Conditions

• Prevention of angina attacks - By dilating coronary arteries, Imdur improves blood flow to the heart muscle, reducing the frequency of chest-pain episodes during physical exertion or emotional stress.
• Guideline-endorsed first-line therapy - The ESC 2023 guideline for chronic coronary syndromes lists long-acting nitrates such as Imdur as a Class IIb option for patients who remain symptomatic despite β-blockers or calcium-channel blockers.
• Reduced myocardial oxygen consumption - Lower preload lessens ventricular wall stress, which translates into a measurable decline in oxygen demand and a subsequent drop in ischemic episodes.
• Compatibility with other anti-ischemic agents - Imdur can be combined with β-blockers, ACE inhibitors, or statins without pharmacokinetic interactions, allowing a tailored multidrug regimen.
• Improved exercise tolerance - Clinical trials demonstrate a 15-20 % increase in treadmill time for patients on stable doses of isosorbide mononitrate compared with placebo.

Off-Label and Investigational Uses of Imdur

Evidence from small pilot studies suggests that isosorbide mononitrate may improve arterial stiffness in patients with heart failure with preserved ejection fraction, but the Health Sciences Authority has not approved this use in Singapore. Off-label use should only be considered under the supervision of a qualified healthcare provider. Larger randomized trials are still required to confirm safety and efficacy in this setting.

Is Imdur Right for You?

Imdur suits adults who experience stable angina despite optimal lifestyle measures and who have no contraindications such as severe hypotension, recent phosphodiesterase-5 inhibitor use, or known hypersensitivity to nitrates. Elderly patients usually tolerate the standard dose, but clinicians may start at a lower dose to mitigate dizziness. Pregnant or breastfeeding women should avoid Imdur unless the benefits clearly outweigh the risks, as nitrate exposure can affect fetal blood flow. Patients with moderate hepatic or renal impairment do not require dose adjustment, though routine monitoring of blood pressure is advisable.

Taking Imdur Effectively

• Timing: Take the tablet each morning with a full glass of water, preferably at the same time daily to maintain steady plasma levels.
• Food interactions: Imdur can be taken with or without food; however, a high-fat meal may delay absorption slightly.
• Lifestyle tips: Avoid sudden position changes; rising slowly from a seated or lying position reduces the likelihood of orthostatic dizziness.
• Missed dose: If a dose is missed and the next scheduled dose is more than 8 hours away, skip the missed tablet and resume the regular schedule-do not double-dose.
• Travel: Carry a copy of your prescription and keep the medication in its original packaging to ease customs clearance.

Understanding Side Effects and How to Manage Them

Common adverse events-headache, flushing, and light-headedness-arise from systemic vasodilation and are usually transient. Taking Imdur with food or at bedtime can lessen headache intensity. If dizziness occurs, sit or lie down until it resolves, and rise slowly thereafter. Rare but serious reactions include severe hypotension, tachycardia, or allergic rash. Should any of these develop, seek immediate medical attention. Long-term nitrate therapy can lead to tolerance; a “nitrate-free interval” of at least 8-10 hours each day (often overnight) helps preserve efficacy.

Buying Imdur from Our Online Pharmacy

Getting Imdur through our online pharmacy combines convenience with cost-effectiveness, especially for patients facing limited stock in brick-and-mortar stores.

Why Choose Our Service?

Our pharmacy service partners with licensed international distributors, ensuring that every Imdur tablet meets stringent quality standards. By ordering through our platform you gain access to medicines that might otherwise be difficult to obtain locally.

Quality & Safety

We work with suppliers who adhere to WHO Good Manufacturing Practices and are regularly audited by regulatory agencies. Each shipment includes a batch-verification certificate, giving you confidence in product authenticity.

Pricing & Access

Because we source Imdur in bulk, we can pass on savings-often 20 % lower than typical retail pharmacy prices. Additionally, generic isosorbide mononitrate alternatives are listed side-by-side, allowing you to compare costs directly. Loyal customers enjoy a lifetime 10 % discount on all reorders.

Discreet Delivery

Orders are packaged in unmarked, protective envelopes. Express shipping delivers within ≈ 7 days, while standard shipping arrives in ≈ 3 weeks, both with tracking to ensure safe arrival.

Frequently Asked Questions

• How quickly will Imdur relieve my chest pain? Imdur is designed for prophylaxis rather than acute relief; it reduces the frequency of attacks over days to weeks rather than terminating an ongoing episode.

• Can I combine Imdur with nitroglycerin patches? Concurrent use of two nitrate preparations can precipitate severe hypotension and is generally avoided unless specifically directed by a cardiologist.

• What should I do if I develop a persistent headache? A mild headache often lessens after a few days. If it remains severe, discuss dose adjustment or an alternate anti-ischemic agent with your physician.

• Is it safe to take Imdur with antihypertensive drugs? Yes, Imdur is frequently prescribed alongside ACE inhibitors or ARBs, but regular blood-pressure monitoring is recommended to avoid excessive drops.

• Does Imdur affect sexual function? Nitrates can potentiate the vasodilatory effect of phosphodiesterase-5 inhibitors, leading to dangerous blood-pressure falls; thus, avoid such combinations.

• Can I stop Imdur abruptly? Stopping suddenly may cause rebound angina. Gradual tapering under medical supervision is advisable for long-term users.

• Are there any dietary restrictions while on Imdur? There are no specific food bans, but excessive alcohol can amplify vasodilatory effects and increase dizziness risk.

• How does Imdur compare to other long-acting nitrates? Isosorbide mononitrate offers once-daily dosing and stable plasma levels, whereas isosorbide dinitrate often requires multiple daily doses, making Imdur more convenient for many patients.

• Will Imdur be covered by Singapore’s MediSave or private insurance? Coverage varies by plan; many private insurers list Imdur as a reimbursable prescription, but MediSave typically does not cover nitrates.

• Is Imdur safe for patients with diabetes? Nitrate therapy does not interfere with glucose metabolism, but diabetic patients should monitor blood pressure closely, as autonomic neuropathy can affect orthostatic responses.

Glossary

Vasodilator

A medication that relaxes smooth-muscle cells in blood-vessel walls, widening the lumen and lowering vascular resistance.

Preload

The volume of blood returning to the heart before contraction; reducing preload eases the heart’s workload.

Cyclic-GMP

A secondary messenger produced after nitric-oxide activation; it promotes smooth-muscle relaxation.

Nitrate tolerance

A phenomenon where continuous nitrate exposure diminishes therapeutic effect, mitigated by daily nitrate-free intervals.

Disclaimer

The information provided about Imdur is for general knowledge only. It does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Imdur for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.

External Resources about Imdur

• Imdur: Uses, Dosage & Side Effects - Drugs.com
• IMDUR DURULES TABLET 60 mg Medication Singapore | IMDUR DURULES TABLET 60 mg Medication | Shim Clinic
• Imdur: Uses, Dosage, Side Effects, Food Interaction & FAQ
• Isosorbide Mononitrate (Imdur, Ismo, others): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
• ISOSORBIDE MONONITRATE SUSTAINED-RELEASE - ORAL (Imdur) side effects, medical uses, and drug interactions.