Buy Ticlid
Ticlid
Ticlid Properties
About Ticlid
Ticlid is a brand-name antiplatelet tablet containing the active ingredient ticlopidine, marketed to help reduce the risk of clot-related cardiovascular events such as ischemic stroke and myocardial infarction. In Singapore it is available by prescription for patients who require an additional option beyond newer agents, and it is taken as a 250 mg pill once daily after an initial loading regimen. While the drug’s primary purpose is to prevent platelet aggregation, clinicians sometimes consider it in specific scenarios where other agents are unsuitable.
What is Ticlid?
Ticlid is a branded formulation of ticlopidine, an oral thienopyridine that inhibits the P2Y12 platelet ADP receptor. The product was developed by Bristol-Myers Squibb and received regulatory approval in the United States in 1991, later gaining approval in several Asian markets, including Singapore, for secondary prevention of ischemic stroke and for reduction of atherothrombotic events after myocardial infarction. Ticlopidine belongs to the antiplatelet class, distinct from anticoagulants such as warfarin, and works by irreversibly blocking platelet activation pathways.
How Ticlid Works
Ticlopidine is absorbed rapidly from the gastrointestinal tract, reaching peak plasma concentrations within 1-2 hours after oral dosing. It is metabolised in the liver to active metabolites that bind covalently to the P2Y12 receptor on the platelet surface, preventing ADP-mediated platelet activation and aggregation. Because the inhibition is irreversible, newly formed platelets are required to restore normal function, which typically takes 5-7 days. The drug has a half-life of approximately 10 hours for the parent compound, but the antiplatelet effect persists for the lifespan of the affected platelets.
Why Ticlid Is Used for Cardiovascular Health Conditions
- Secondary stroke prevention: By blocking platelet aggregation, Ticlid reduces the likelihood of recurrent ischemic stroke after a transient ischemic attack (TIA) or minor stroke. Clinical trials demonstrated a relative risk reduction of about 20 % compared with placebo (FDA label, 1994).
- Post-myial infarction (MI) management: In patients who have experienced an MI, Ticlid lowers the risk of subsequent atherothrombotic events, complementing other secondary-prevention strategies.
- Peripheral arterial disease (PAD): Some guidelines list ticlopidine as an alternative for patients with PAD who cannot tolerate clopidogrel.
- Guideline position: Historically, Ticlid was a first-line option before the introduction of clopidogrel and newer P2Y12 inhibitors. Current Singaporean cardiology guidelines reserve it for patients with documented intolerance or contraindication to newer agents.
Off-Label and Investigational Uses of Ticlid
- Acute coronary syndrome (ACS) when clopidogrel is unavailable: Small randomized studies have explored ticlopidine as a bridge therapy. Evidence remains limited, and the drug is not approved for ACS in Singapore.
- Preventing stent thrombosis in patients with hypersensitivity to cobalt-chromium stents: Case reports suggest potential benefit, but data are anecdotal.
Off-label use should only be considered under the supervision of a qualified healthcare provider.
Is Ticlid Right for You?
Ticlid may be appropriate for adults who have experienced a recent ischemic stroke, TIA, or MI and who cannot use clopidogrel or prasugrel due to allergy, drug interaction, or cost concerns. It is generally avoided in patients with a history of neutropenia, thrombocytopenia, or severe hepatic impairment because of the higher risk of hematologic toxicity. Pregnant or breastfeeding individuals should discuss alternatives with their physician, as safety data are insufficient. Elderly patients may require closer monitoring of blood counts during the first few weeks of therapy.
Taking Ticlid Effectively
- Loading dose: The typical initiation regimen is 250 mg twice daily for the first three days, followed by 250 mg once daily thereafter.
- Food interactions: Ticlid can be taken with or without food; however, consistent timing with meals may improve gastrointestinal tolerance.
- Missed dose: If a dose is missed within 12 hours, take it as soon as remembered; otherwise, skip and resume the regular schedule-do not double-dose.
- Travel tips: Carry a written prescription and keep the medication in its original container to avoid customs delays.
- Lifestyle integration: Avoid concomitant use of non-steroidal anti-inflammatory drugs (NSAIDs) without medical advice, as they may increase bleeding risk.
Understanding Side Effects and How to Manage Them
- Common reactions (headache, nausea, dyspepsia): These are often related to the drug’s effect on gastric mucosa. Taking the pill with a light meal and staying well-hydrated can mitigate discomfort.
- Hematologic toxicity (neutropenia, thrombocytopenia): Ticlopidine can suppress bone-marrow production, typically manifesting within the first two weeks. Weekly complete-blood-count monitoring is recommended during initiation; if white-cell counts fall below 3,000 µL⁻¹ or platelets below 150,000 µL⁻¹, discontinue the medication and seek medical advice.
- Bleeding: As an antiplatelet, Ticlid prolongs bleeding time. Patients should report any unexplained bruising, gum bleeding, or hematuria promptly. Use of additional anticoagulants (e.g., warfarin) should be coordinated by a physician.
Buying Ticlid from Our Online Pharmacy
Why Choose Our Service?
Through our platform you can obtain Ticlid without the long wait times often encountered at local dispensaries, especially when stock is limited.
Quality & Safety
We partner with licensed international pharmacies that adhere to WHO-guided Good Manufacturing Practices, ensuring each pill meets rigorous potency and purity standards.
Pricing & Access
Our online pharmacy offers Ticlid at a competitive price point, typically 30 % lower than retail pharmacy rates in Singapore. For patients who switch to a generic ticlopidine alternative, we provide an additional “Lifetime 10 % discount on all reorders.”
Discreet Delivery
Express shipping arrives in approximately 7 days, while standard delivery takes up to 3 weeks. All packages are sealed in neutral-labeled boxes to protect your privacy.
Frequently Asked Questions
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What makes Ticlid different from clopidogrel? Ticlid (ticlopidine) and clopidogrel both block the P2Y12 receptor, but ticlopidine has a slower onset and a higher incidence of hematologic side effects, which is why clopidogrel is preferred for most patients.
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Can I take Ticlid with aspirin? Dual antiplatelet therapy (aspirin + Ticlid) is sometimes prescribed after certain cardiac procedures, but the combination increases bleeding risk and should only be used under medical supervision.
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How long will I need to stay on Ticlid? Duration depends on the indication; secondary stroke prevention often requires lifelong therapy, whereas post-MI regimens may be limited to 12 months based on physician assessment.
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Is it safe to stop Ticlid abruptly? Stopping suddenly can restore platelet function within a week, potentially raising clot risk. Discuss tapering or alternative therapy with your clinician before discontinuation.
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Will Ticlid interact with my cholesterol medication? No direct pharmacokinetic interaction is known with statins, but both drugs may increase bleeding tendency when combined with anticoagulants; monitoring is advisable.
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What monitoring is required while I’m on Ticlid? Baseline and weekly complete-blood-count tests for the first month, then monthly thereafter, are standard to detect neutropenia or thrombocytopenia early.
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Can I purchase Ticlid without a prescription through your service? No. Ticlid is a prescription-only medication in Singapore, and we require a valid prescription from a licensed healthcare professional before dispensing.
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Are there generic versions of Ticlid available? Yes, generic ticlopidine tablets contain the same active ingredient and are bio-equivalent, offering a cost-effective alternative when prescribed.
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What should I do if I experience severe bruising? Severe bruising may signal a bleeding complication; seek immediate medical attention, especially if accompanied by dizziness or blood in urine or stool.
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Is Ticlid appropriate for patients with kidney disease? Mild to moderate renal impairment does not require dose adjustment, but severe impairment warrants careful risk-benefit evaluation and close laboratory monitoring.
Glossary
- P2Y12 receptor
- A platelet surface protein that, when activated by ADP, triggers platelet aggregation; blockade reduces clot formation.
- Irreversible inhibition
- A mechanism where the drug forms a permanent bond with its target, requiring new platelet production to restore function.
- Thienopyridine
- A class of antiplatelet agents, including ticlopidine and clopidogrel, that share a common chemical scaffold and mode of action.
- Hemopoietic toxicity
- Suppression of bone-marrow activity leading to decreased blood cell counts, a known risk of ticlopidine.
- Dual antiplatelet therapy (DAPT)
- The combined use of two antiplatelet drugs (commonly aspirin plus a P2Y12 inhibitor) to enhance protection against clot formation after certain cardiovascular procedures.
Disclaimer
The information provided about Ticlid is for general knowledge only and does not replace professional medical consultation. All treatment decisions, including those regarding off-label use, should be made under the supervision of a qualified healthcare provider. We assume all readers are responsible adults capable of making informed decisions about their health. Our online pharmacy offers access to Ticlid for individuals who may have limited availability through traditional pharmacies, prescription-based insurance schemes, or who are seeking affordable generic alternatives. Always consult your doctor before starting, changing, or discontinuing any medication.
